Protein Alignment Ank and kri-1

DIOPT Version :10

• Sequence 1: NP_787122.1
• Gene: Ank / 43770
• FlyBaseID: FBgn0011747
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001021863.1
• Gene: kri-1 / 191275
• WormBaseID: WBGene00013955
• Length: 729
• Species: Caenorhabditis elegans
• Alignment Length: 789
• Identity: 138/789 - (17%)
• Similarity: 249/789 - (31%)
• Gaps: 276/789 - (34%)

  Fly   514 MLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNV 578
            |:|:.....|::|:.|.|...|...||.....::..:.|.|         |..|...|.....:.
 Worm   169 MILILERWLIDSQTFDSYFLSHFFMKESSRTRIKTCVHNPA---------FIDLQEQCIRHMSHS 224

  Fly   579 VQILLQNGASIDFQGKNDVTPLHVAT-------HYNNPSIVELLLKNGSSPNLCARNGQCAIHIA 636
            |:..: :.||.|...:     :|||.       .||..:|  .::....:||..:.:..|...
 Worm   225 VRSNV-SSASADLDDR-----VHVANIAKIAMLRYNKFTI--SVINPAFNPNFASEDSSCVYF-- 279

  Fly   637 CKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLTPLHVA 701
                |..|.....|.                 ||...:.||              ::.|.|||.|
 Worm   280 ----YPGIKQCRAQR-----------------AASSTSQDM--------------RSRLYPLHKA 309

  Fly   702 AQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIEND--ADIEMSSNIGYTPL 764
            |::|:....:..|:.|.:.:.|..:.:||||.|..:|||::|...:.:.  ..|...:..|.|.|
 Worm   310 AEDGNAEEIRRFLKIGMDSNLRDDDSWTPLHYACFHGHLEVVHELLNSPQMTAINAQNKGGATAL 374

  Fly   765 HQAAQQGHIMIINLLLRHKA-NPNALTKDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIGAI 828
            ..|...|:..::.:|..|.: :.|....:|...:....|...:..:..|:|..|...::::||:.
 Worm   375 QYAVINGNEYLVEILTSHASIDVNIQNNEGYRPIDYCGNHPAIQKILELQIFKSKINVDTSIGSF 439

  Fly   829 EEKLKVMTPELMQETLLSDSDDESCDDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHDLTDV 893
              .:|..:||           :.:..::||.                              |.:.
 Worm   440 --SIKSRSPE-----------EATVGEVLDR------------------------------LAEE 461

  Fly   894 SVLNKKEILPNEMSCIELTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVP 958
            :.||::     :|:|..|                         .|.:...|::
 Worm   462 TQLNRE-----QMNCFAL-------------------------FVYSESMSLQ------------ 484

  Fly   959 PKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPH-------YG 1016
                                :.|..|::|:..|.:   .:......:..|..|.|.       |.
 Worm   485 --------------------LQPDSLIDGKLKVDK---WNTTIRKLVGDIPFETPRLKLKRNAYA 526

  Fly  1017 TLRKNEREIIILRSDNGESWREHNLYKDIIGEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQ 1081
            |.|   .||:....:|..:|      ..|:.|.|:   .:.:..::....:.:..|.|:|.|.
 Worm   527 TAR---MEIVTKVDNNSFAW------STILDEAIH---SYLAGHLIANSKEEITKFAAIVCRT-- 577

  Fly  1082 EVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEP 1146
             :|      |..|..:...:..::|.:.|....|             .||..:         ::.
 Worm   578 -MH------GRDFKPSSKNLSNLYPQYMLDNHDR-------------GKLADR---------LKA 613

  Fly  1147 RRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFV 1211
            :.||                           |.:...::|....                 :|..
 Worm   614 QLRK---------------------------NETQNDMQLEAEF-----------------ISMA 634

  Fly  1212 RDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMT 1276
            |..||:    .|.|:.:|   :.....|.||  ..|..|..:...:||.|..:....:|..| ..
 Worm   635 RGLVTY----GASFFDVD---VFTKKSMGTE--QGLVGVNDHGLHIIFKKTWTVKNFRFDEF-TA 689

  Fly  1277 DDKEDKTLE 1285
            .:||.||||
 Worm   690 SNKESKTLE 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_787122.1	ANKYR	20..337	CDD:440430
		ANK repeat	72..103	CDD:293786
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK repeat	204..231	CDD:293786
		ANKYR	217..502	CDD:440430
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK repeat	299..330	CDD:293786
		ANK repeat	332..363	CDD:293786
		ANK repeat	365..395	CDD:293786
		ANK repeat	398..427	CDD:293786
		ANK repeat	431..462	CDD:293786
		ANK repeat	464..494	CDD:293786
		ANK repeat	496..527	CDD:293786	3/12 (25%)
		ANKYR	510..797	CDD:440430	63/292 (22%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		ANK repeat	562..590	CDD:293786	6/27 (22%)
		ANK repeat	595..625	CDD:293786	8/36 (22%)
		ANK repeat	628..657	CDD:293786	4/28 (14%)
		ANK repeat	661..691	CDD:293786	4/29 (14%)
		ANK repeat	693..724	CDD:293786	9/30 (30%)
		ANK repeat	726..755	CDD:293786	10/30 (33%)
		ANK repeat	759..788	CDD:293786	7/29 (24%)
		ZU5	930..1034	CDD:128514	15/110 (14%)
		UPA_2	1250..1378	CDD:375346	12/36 (33%)
		Death_ank	1439..1521	CDD:260029
kri-1	NP_001021863.1	NUDIX_5	<126..210	CDD:465241	11/49 (22%)
		ANKYR	<305..437	CDD:440430	32/131 (24%)
		ANK repeat	305..332	CDD:293786	8/26 (31%)
		ANK repeat	334..367	CDD:293786	10/32 (31%)
		ANK repeat	369..401	CDD:293786	8/31 (26%)
		FERM_M	549..645	CDD:459788	23/177 (13%)