DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and F36D3.5

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_507181.3	Gene:	F36D3.5 / 185352	WormBaseID:	WBGene00009471	Length:	1215	Species:	Caenorhabditis elegans

Alignment Length:	1074	Identity:	206/1074 - (19%)
Similarity:	332/1074 - (30%)	Gaps:	412/1074 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NKIQTRSETCAINGMALDNKNGI---------IKQNDA-TISFLRAARSGDIKKVMDFLDCGEIS 64
            |...:..:......||..||:.:         :|||.. |..|   ..|||..|:        ..
Worm   269 NSPSSLGQKMVFEAMAQLNKSIVEAKSHNISPVKQNLLFTAGF---KNSGDFSKI--------AG 322

  Fly    65 DINS-------CNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVI 122
            |:||       ...:..|:|..|     ::|...:..:.:.:|::.|:   .:|:.. ..|:..:
Worm   323 DLNSNWFKKHVAKGSSTNSLSNA-----LEIFQTISGKMVALDSSWKE---LMHVTK-GFQNLPV 378

  Fly   123 NQLILYNANVNVQSLNGFTPLYMAAQEN--HDNCC--RTLLANGANPSLSTEDGFTPLAVAMQQG 183
            .:.:...|:|....|| |:.|....|::  |.|.|  .||||.....|..
Worm   379 VERVNNAADVATIGLN-FSKLERIIQDSRIHINNCMKETLLARSKLKSFD--------------- 427

  Fly   184 HDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAH---YG 245
                 |.::|.:   |...||.:|..:..::.            ||:::     |.:|.:   |.
Worm   428 -----ASIVEYE---KYMFPAENIMNRLANIK------------DIIAE-----LTVALNFMVYP 467

  Fly   246 NVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRS 310
            |.....|..::                          |..|....:|:|..|.:.:|..:...|.
Worm   468 NTQARDLFKDD--------------------------CHTLYWTLSKLDVNTSNAITVKNMLIRD 506

  Fly   311 ---------GHVEVIKHL--LQQNAPILTKTKNGL------------SALHMAAQGE----HDEA 348
                     ..::.:|.:  :.....|:.||..|:            |.|.:....:    |.|.
Worm   507 FKKLTHHSYSFIDTMKSIAKISSELKIVEKTSAGIYDSDGPNLGDLVSELELVKTSQCFSHHSET 571

  Fly   349 -------AHLLLDNKAPVDEVTV----DYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTP 402
                   .|.|...:.|.|..|.    :||..|.        ||
Worm   572 IQELMLIVHKLYSTRYPPDHATSSTMHEYLDRLE--------KV--------------------- 607

  Fly   403 LHIACKKNRIKMVELLIKHGAN-IGATTESGL---TPLHVASFMGCINIVIYLL----QHEA--- 456
                  :|.:.:||..||..:: |.||....|   ||..:...:|....|:..|    ||..
Worm   608 ------QNNLALVEKEIKSSSSQINATNNPVLLLKTPQALIKNIGTSTRVLEDLENVRQHRQFLF 666

  Fly   457 -----SADL-PTIRGET------P----LHLAARANQ-------------ADIIRILLRSAKVDA 492
                 :||: ..|.||.      |    :.|...|:|             .::.|:...:||:..
Worm   667 SVRNFTADVKKVIVGENLIEWFDPEEKLIELLEEADQLNEFAGKLRNGSLTEMSRVFDEAAKIKG 731

  Fly   493 IAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKY----------SALHIAAKEGQENIVQ 547
            |..:.|          ::|.:.:.||....|:..:..|.          .|.|.||.:.....|.
Worm   732 INGDSQ----------SLNTLSIKLQKSVGIDQLAASKVFQKIREFNLDFAKHEAALKSASVTVN 786

  Fly   548 VL-----------------LENGAENN--------------------AVTKKGFTPLHLACKYGK 575
            .|                 :|...:|:                    .|...|||      |.|:
Worm   787 SLVAYYDEIFGNSKSKILTIEKHIDNSFPWIYIFLICIGSMILIGLLCVVAYGFT------KNGR 845

  Fly   576 QNVVQILLQN-GASIDFQ-------------GKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCA 626
            ...:.:.|.. |..:|::             |||  |.|......|...:|: .:|.|:..|...
Worm   846 AKYMNLYLYYFGKPLDYERRWRYSLFLDNQGGKN--TLLDAVREINKTHVVK-AVKMGAYINAFN 907

  Fly   627 RNGQCAIHIACKKNYLEIAMQLLQHGAD---VNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVIS 688
            :.|..|:|:|.|....||...|::||||   :|.::|:....:.||:...:.|||:.|.:..::.
Worm   908 KFGNTALHVATKSALPEIVKILIEHGADLTLLNTLNKTPEQMIPLASPDHSKDMVEKLEKIRMLY 972

  Fly   689 AAAKNG-----LTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIE 748
            ..| ||     ..|....|...|:.           :.|||.|..|.          |.::.|
Worm   973 KKA-NGKKYRMSVPQKFPATSFHIW-----------MDERTDNKITN----------DFMEKF-- 1013

  Fly   749 NDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESLK 813
                                                  .|:|.|     ..|.|..:|.|.....
Worm  1014 --------------------------------------QAITSD-----EAAPNTTHVIVKTDEN 1035

  Fly   814 IVTSTS-------VINSNIGAIEEKLKVMTPELMQETLLSDSDDESCDDLLDHNHYK-------- 863
            .|..|.       |.|   |||..|.:.|...|.:|.|:    ::....|:|...||
Worm  1036 GVLETDDLDLLFWVFN---GAIIVKEQWMIDCLNEEKLI----EQDSKYLVDSVKYKGSTFKTVL 1093

  Fly   864 ----YMATDDLKANYG-------QDQKNFDTTNT 886
                .||...:...||       .:.||..|.||
Worm  1094 QWSEAMAKGAIPYLYGVYAAIVMTECKNLVTLNT 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	26/135 (19%)
		ANK repeat	72..103	CDD:293786	5/30 (17%)
		Ank_2	77..167	CDD:289560	21/93 (23%)
		ANK repeat	105..136	CDD:293786	4/30 (13%)
		ANK repeat	138..169	CDD:293786	12/34 (35%)
		ANK	204..320	CDD:238125	17/129 (13%)
		ANK repeat	204..231	CDD:293786	4/26 (15%)
		Ank_2	205..295	CDD:289560	11/92 (12%)
		ANK repeat	233..264	CDD:293786	5/33 (15%)
		ANK repeat	266..295	CDD:293786	3/28 (11%)
		ANK	294..419	CDD:238125	26/162 (16%)
		ANK repeat	299..330	CDD:293786	4/41 (10%)
		Ank_4	300..353	CDD:290365	12/86 (14%)
		ANK repeat	332..363	CDD:293786	9/53 (17%)
		Ank_2	337..428	CDD:289560	19/106 (18%)
		ANK	360..485	CDD:238125	33/168 (20%)
		ANK repeat	365..395	CDD:293786	5/29 (17%)
		ANK repeat	398..427	CDD:293786	6/29 (21%)
		ANK repeat	431..462	CDD:293786	10/46 (22%)
		Ank_2	436..526	CDD:289560	23/125 (18%)
		ANK repeat	464..494	CDD:293786	9/52 (17%)
		ANK	491..616	CDD:238125	31/185 (17%)
		ANK repeat	496..527	CDD:293786	5/30 (17%)
		Ank_2	501..592	CDD:289560	22/138 (16%)
		ANK repeat	529..560	CDD:293786	9/77 (12%)
		ANK	557..682	CDD:238125	38/161 (24%)
		ANK repeat	562..590	CDD:293786	7/28 (25%)
		Ank_5	582..636	CDD:290568	16/67 (24%)
		ANK repeat	595..625	CDD:293786	8/29 (28%)
		ANK repeat	628..657	CDD:293786	12/31 (39%)
		Ank_2	633..723	CDD:289560	24/97 (25%)
		ANK repeat	661..691	CDD:293786	6/29 (21%)
		ANK	692..812	CDD:238125	19/124 (15%)
		ANK repeat	693..724	CDD:293786	6/35 (17%)
		Ank_2	698..788	CDD:289560	9/89 (10%)
		ANK repeat	726..755	CDD:293786	4/28 (14%)
		ANK repeat	759..788	CDD:293786	0/28 (0%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
F36D3.5	NP_507181.3	WSN	25..93	CDD:197734
		ANK	<873..946	CDD:238125	24/75 (32%)
		ANK repeat	876..907	CDD:293786	10/33 (30%)
		Ank_4	879..930	CDD:290365	15/53 (28%)
		ANK repeat	909..940	CDD:293786	12/30 (40%)
		BRCT	985..1065	CDD:214602	26/148 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900