DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and C18H2.5

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_741231.2	Gene:	C18H2.5 / 176082	WormBaseID:	WBGene00015992	Length:	1195	Species:	Caenorhabditis elegans

Alignment Length:	891	Identity:	165/891 - (18%)
Similarity:	309/891 - (34%)	Gaps:	278/891 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   791 KDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIGAIEE--KLKVMTPELMQETLLSDSDDESC 853
            :|...|:.....|.|.|:.   |:...|..|.....||::  |.:....||::..|.:.|...:.
Worm    32 RDARGAVKSHLELAYETIN---KLSRVTLAIAYEAAAIQQSFKFRPALGELLEANLANLSTIITH 93

  Fly   854 DDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHD------------LTDVS---VLNKKEILP 903
            :.|..:||     .|.:...|   ::.:::||.|.|            :|.||   |:||.:|
Worm    94 NPLTVNNH-----LDGIVERY---KRIYESTNGDKDDLLRILKLNEDLMTSVSSDYVVNKTKI-- 148

  Fly   904 NEMSCIELTEIGHKPDNVVIAR----SQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAE 964
            ::.       ..|..:|..|:|    ::.|:..:|.|.                .:|...||..|
Worm   149 HDF-------FDHLGNNSTISRLKGCNETHVEMIVEFW----------------NVINEKKAANE 190

  Fly   965 PTR----ITCRYVKPQRVVNPPPLMEGEALVSRILEMSPV-DGMFLSPITLEV-----------P 1013
            ..:    :|.:...|:.......:.|..:.|..|.::..| ..:|.:..|:|:           |
Worm   191 DDKKIAIVTLKNRIPEVRQCMTSIKEYYSFVYPISKVGEVFRNIFSARATVELFKKKQIEYENFP 255

  Fly  1014 HYGTLRKNEREIIILRSDNGESWR--EHNLYKDIIGEDINQTEEFHSDRIVRIVTQN--VPHFFA 1074
            :.....||..:.||      :.|.  :.::||     :::.|.:.|.|.:     ||  :..:.:
Worm   256 NDLEKLKNIAKKII------KDWEAPQVDVYK-----EVSMTVQLHKDMV-----QNKTMAVWLS 304

  Fly  1075 VVS-RVRQEVHVIGPDGGTV-FSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVA 1137
            :|. .:.:::.::..|..:| |...|...|:|       |.:...|:|    ..:.|:..|:
Worm   305 LVGYGLIEDLKMVREDLNSVWFKEKVANGKSI-------KFLENSLEA----FFKFSEYTGK--- 355

  Fly  1138 VSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNAC--YGNGNSSSPTLRLL---CSISGGQTRA 1197
               :.|...:.:.|.||...:: .......|.:|.|  ..:|..:...::.:   |.....||
Worm   356 ---LETTWIKFKAFFKAERKNL-LESLSFYSSINQCSDVASGEGAIENMKKIYNGCWKGSAQT-- 414

  Fly  1198 TWEDVTGSTPLSFVRDSVTFTTTVSARF----WLIDCRNII---DAGRMATELYS----HLAKV- 1250
              ||..     .|...|.|.:...|..|    |   |...:   |...|.|.|.|    :|..:
Worm   415 --EDFA-----RFDEHSKTLSDLNSTIFEVLAW---CNETVKQNDFDVMETALDSLNNLNLENLN 469

  Fly  1251 ------------------PFYVKFVIF--------------------------AKRISQTEAKFS 1271
                              .|:.:|:.|                          |..::::::..:
Worm   470 PQETINEVREIQNFEDLNDFFERFLRFHLLQKKYDTDYQLLHKVNLVDVMEETAANLTKSKSIAN 534

  Fly  1272 VFCM-----TDDKEDKTLEQQEYFKEVAKSRDIEVLQNQI-VYLEFAGNIVPI----------LK 1320
            :.|:     ...|...|:|.....:.:..|.|.:.:::.: :|.:...:.|.:          .|
Worm   535 LKCLKMKEFQSSKIHSTVEFITSVRRIGNSSDHKKIKDAVKIYSDMRTDYVAVEKFLEETRRQSK 599

  Fly  1321 KGEQLYTKFQPFCENRLSFSAHIKDQEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFK---T 1382
            :.||| ||..|..:.:.|.....|   ...|.||..                  ::...:|   .
Worm   600 QNEQL-TKQNPVLKFKHSMKIATK---LAKGMICLR------------------DLIESYKLRSE 642

  Fly  1383 ITNHLERDNLHSLNDCINAHGKLNHNENIVFGVKEQQVKKIDITKACIMSSDIKLIHEADVILDD 1447
            |.|....||  .:||.|     .|.|||       :|||:........:...:  :.|.|.:..:
Worm   643 ILNSANYDN--GVNDKI-----ANFNEN-------KQVKEFWSGSPGYLLEHV--VRELDNLNME 691

  Fly  1448 ICSHLGSD-------WPLLANVLGVSQADI------------DLVKTEFLLNDSVKQSMAMLQLW 1493
            ...::|||       :.:..||.|:...|:            |:....|.:  :.|.|..:.:||
Worm   692 ARKYIGSDLGTIGTLFDVATNVSGIKGVDLLFEYVHDQLDSYDVKDKNFQM--AKKNSENLAELW 754

  Fly  1494 LE----HGGILTGN-------VLAEALYKIGRSDIVEKSFKNAEFG 1528
            |:    |..:...:       ...:.::|:.:|   ||.|.|:..|
Worm   755 LDFTVNHQDLRAASESIKDIKEYFDEIFKVNKS---EKVFVNSYLG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365
		ANK repeat	332..363	CDD:293786
		Ank_2	337..428	CDD:289560
		ANK	360..485	CDD:238125
		ANK repeat	365..395	CDD:293786
		ANK repeat	398..427	CDD:293786
		ANK repeat	431..462	CDD:293786
		Ank_2	436..526	CDD:289560
		ANK repeat	464..494	CDD:293786
		ANK	491..616	CDD:238125
		ANK repeat	496..527	CDD:293786
		Ank_2	501..592	CDD:289560
		ANK repeat	529..560	CDD:293786
		ANK	557..682	CDD:238125
		ANK repeat	562..590	CDD:293786
		Ank_5	582..636	CDD:290568
		ANK repeat	595..625	CDD:293786
		ANK repeat	628..657	CDD:293786
		Ank_2	633..723	CDD:289560
		ANK repeat	661..691	CDD:293786
		ANK	692..812	CDD:238125	5/20 (25%)
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514	20/119 (17%)
		Death_ank	1439..1521	CDD:260029	20/111 (18%)
C18H2.5	NP_741231.2	WSN	40..108	CDD:197734	17/75 (23%)
		Ank_4	856..909	CDD:290365
		ANK	860..>924	CDD:238125
		ANK repeat	860..886	CDD:293786
		ANK repeat	888..922	CDD:293786
		BRCT	964..1044	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900