DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and F37A4.4

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_498471.1	Gene:	F37A4.4 / 175945	WormBaseID:	WBGene00018134	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	626	Identity:	118/626 - (18%)
Similarity:	230/626 - (36%)	Gaps:	178/626 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVD--ICCELLRRGIK-IDNATKKGNT 108
            |:.|.||.::..:    :...:|..|..|||....:..::.  ....||.|.:: ::....:.:|
Worm   372 RNVDKKKFLENFE----ATFRTCFKNYKNALDQGEETKFLKNFSAVYLLVRSVQAVEQWASEIST 432

  Fly   109 ALHIASLAGQHDVINQLILYNANVNVQS----------LNGFTPLYMAAQENHDNCCRTLLANGA 163
            .....::....:.:.:|...|....|:.          :|.||.| .:.|..:::..:|  :|.:
Worm   433 MFDEKAMDVYFEELEKLTPSNIKEQVEKITNFDDFLKIINKFTML-KSLQTQYESAYKT--SNSS 494

  Fly   164 NPSLS---TEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHI------AAKKNDVNAAKL 219
            ..|||   |:.|....:..:::  ||:.:..|...::....:..|.|      |...|.....|.
Worm   495 ELSLSKIITDAGLVDTSKCLEK--DKLDSSKLLKMLQFMQHMMQLDIDYSTLKANLDNFFELKKK 557

  Fly   220 LLQHDP--------NADIVSKSGFTPLHI------AAHYGN------------VDIATLL----L 254
            :|:.:.        :|...|.||...|.|      |.|.||            .:.||:|    .
Worm   558 MLETEKLVKGFTSRSARAASNSGSPVLKIKDSQKHADHLGNGLLAIKKMIISLKEKATILKSTMF 622

  Fly   255 NNKAD--------VNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRS- 310
            |.||:        ::|:.:....|                   |..|:....| |..|..:|:|
Worm   623 NAKANQEIREKNPIDYIKEFWTNP-------------------GPSIEKLVSD-LEKLEQSSKSY 667

  Fly   311 --GHVEVIKHLLQQNAPILTKTKNGLSAL--HMAAQGEHDEAAHLLLDNKAPVDEV--TVDYLTA 369
              ..:..|:.:.:..:.|:     |:..:  ::.:|.|...:.:   .|:..:.:.  |:|
Worm   668 RKADLLTIRKVFEDGSKIV-----GIPEVFSYIDSQFEKKGSQY---SNERKITQALSTLD---- 720

  Fly   370 LHVAAHCGHVKVAKLLLDYKANPNARA----LNGFTPLHIACKKNRIKMVELLIKHGANIGATTE 430
            |:.|:|.|.:..|.|.:|     |.:.    |.|.||                     .:...:|
Worm   721 LNFASHKGALSAASLSVD-----NLKLYFDDLFGLTP---------------------KVSVQSE 759

  Fly   431 SGLTPLHVASFMGCINIV-----------------------IYLLQHEASAD----------LPT 462
            | .:|:.|.  :.|:.||                       :||.....::|          :..
Worm   760 S-TSPIVVV--LICVAIVLVLVILAIVGYGFTSNGRNQYINLYLYYFGKTSDYEKRWRYSLFMDR 821

  Fly   463 IRGETPLHLAAR-ANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAE---I 523
            :.|:..|..:.| .|..::::.:.|.|.::...:.|.|.||||:|.|..|::.:|::|||:   :
Worm   822 VDGKNVLIDSVREINATNLLKAVKRGAYINVCNKYGNTALHVATRRGYQNLVEILIKHGADRSFL 886

  Fly   524 NAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGF 564
            |.|:......:.:..:|..:..::......:..|...||.|
Worm   887 NPQNKTAEQMIPVNYQETHKEKIERFKSIESIYNKYRKKKF 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	26/140 (19%)
		ANK repeat	72..103	CDD:293786	7/33 (21%)
		Ank_2	77..167	CDD:289560	15/102 (15%)
		ANK repeat	105..136	CDD:293786	4/30 (13%)
		ANK repeat	138..169	CDD:293786	10/33 (30%)
		ANK	204..320	CDD:238125	32/162 (20%)
		ANK repeat	204..231	CDD:293786	7/40 (18%)
		Ank_2	205..295	CDD:289560	26/133 (20%)
		ANK repeat	233..264	CDD:293786	15/60 (25%)
		ANK repeat	266..295	CDD:293786	3/28 (11%)
		ANK	294..419	CDD:238125	25/135 (19%)
		ANK repeat	299..330	CDD:293786	7/33 (21%)
		Ank_4	300..353	CDD:290365	9/57 (16%)
		ANK repeat	332..363	CDD:293786	4/34 (12%)
		Ank_2	337..428	CDD:289560	17/98 (17%)
		ANK	360..485	CDD:238125	28/164 (17%)
		ANK repeat	365..395	CDD:293786	9/29 (31%)
		ANK repeat	398..427	CDD:293786	3/28 (11%)
		ANK repeat	431..462	CDD:293786	9/63 (14%)
		Ank_2	436..526	CDD:289560	27/126 (21%)
		ANK repeat	464..494	CDD:293786	6/30 (20%)
		ANK	491..616	CDD:238125	20/77 (26%)
		ANK repeat	496..527	CDD:293786	14/33 (42%)
		Ank_2	501..592	CDD:289560	18/67 (27%)
		ANK repeat	529..560	CDD:293786	2/30 (7%)
		ANK	557..682	CDD:238125	4/8 (50%)
		ANK repeat	562..590	CDD:293786	2/3 (67%)
		Ank_5	582..636	CDD:290568
		ANK repeat	595..625	CDD:293786
		ANK repeat	628..657	CDD:293786
		Ank_2	633..723	CDD:289560
		ANK repeat	661..691	CDD:293786
		ANK	692..812	CDD:238125
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
F37A4.4	NP_498471.1	WSN	27..95	CDD:197734
		Ank_2	844..>893	CDD:289560	17/48 (35%)
		ANK	<844..893	CDD:238125	17/48 (35%)
		ANK repeat	856..887	CDD:293786	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900