DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank and sel-15

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001366799.1 Gene:sel-15 / 175225 WormBaseID:WBGene00016030 Length:847 Species:Caenorhabditis elegans


Alignment Length:668 Identity:162/668 - (24%)
Similarity:268/668 - (40%) Gaps:144/668 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 KHLLQQNAPILTKTKNGLSALHMAAQGEHD---EAAHLLLDNKAPVDEVTV------DYLTALHV 372
            :|:..:||.:  |:...||..|:...|..|   |....|:||......:|:      :..|.||:
 Worm    60 QHMCPENAEL--KSTQLLSLFHIICAGHSDSQPEKLQFLIDNLPKESSITLISSQSANGFTPLHI 122

  Fly   373 AAHCGHVKVAKLLLDYK---ANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLT 434
            |.:.|.|.:.|.|:..|   .:.:.|.|  ...||:|......:|:.:|:..||||..|.....|
 Worm   123 AIYRGDVAILKALIATKLVDLDQSGRHL--LPALHLAAMIGDSEMLTILLNSGANIHVTDFVHFT 185

  Fly   435 PLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRSAKVDAIAR--EG 497
            .||.|::.|..|.|..|:...|:.:|.....:.|:||||......|.::|| .||.|.:..  ||
 Worm   186 ALHCATYFGQENAVRTLISASANLNLGGAVNDRPIHLAAAKGLTSITKLLL-EAKADPLLADDEG 249

  Fly   498 QTPLHVASRLGNINIIMLLLQ--HGAEINAQSNDKY--SALHIAAKEGQENIVQVLLENGAENNA 558
            ...||.|::.|::.|:.:|::  .|......:.:.|  :|||::...|:.:||:.:|::...|..
 Worm   250 NQALHYAAKSGSLVILNMLIKQVRGTNDRICARNLYGDTALHLSCYSGRLDIVKSILDSSPTNIV 314

  Fly   559 VTKKGF--TPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK-NGS 620
            ..:..|  ||||.||..||            ||:                    :|..|:| .|.
 Worm   315 NMENVFSETPLHAACTGGK------------SIE--------------------LVSFLMKYPGV 347

  Fly   621 SPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKS--GFSPLHLAAQGGN-----VDMV 678
            .||...::|..|:|.||...:|.|...||::|||.::.|::  |.:....|..|.|     ...:
 Worm   348 DPNYQGQDGHTALHSACYHGHLRIVQYLLENGADQSLASRAFEGGALRQQAGPGTNRPSKVASAI 412

  Fly   679 QLLLEYGVISAAAK--------NGLTPLHVAAQEGHVLVSQILLEHGANISE--------RTRNG 727
            ..|......|:.|.        :..||:..|.:.||..:..:|..:.|...|        ...:.
 Worm   413 MALNRSDTPSSNASYNSTVSLDDQQTPVIWAYERGHDAIVALLKHYAARTVEGDVCSEYSSGESS 477

  Fly   728 YTPLHMAAHYGHL--------DLVKF-------FIENDADIEMSSNIG---YTPLHQAAQQGHIM 774
            ||||  .:..|.|        ||::.       |....|:||...:||   :..:::...:|.::
 Worm   478 YTPL--PSPMGRLTSLTRDKADLLQLRSALPAPFHLCLAEIEFQESIGSGSFGKVYKGTYRGKLV 540

  Fly   775 IIN--------------------LLLRHKANPNALTKDGNTALHIASNLGYVTVMESLKIVTSTS 819
            .:.                    .:|...|:||.:...| |:|...|....:|     :.|.:.|
 Worm   541 AVKRYRAMAFGCKSETDMLCREVSILSRLAHPNVVAFVG-TSLDDPSQFAIIT-----EFVENGS 599

  Fly   820 VINSNIGAIEEKLKVMTPELMQETLLSDSD-----DESC------DDLLDHNHYKYMATDDLKAN 873
            :..    .:.|:.:||.|.......|..:.     .||.      .||..||...:.....:.|:
 Worm   600 LFR----LLHEEKRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVAD 660

  Fly   874 YGQDQKNFDTTNTDHDLT 891
            :|:.:  |.....|.:||
 Worm   661 FGESR--FVCQREDENLT 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125 1/2 (50%)
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125 29/113 (26%)
ANK repeat 299..330 CDD:293786 3/12 (25%)
Ank_4 300..353 CDD:290365 10/38 (26%)
ANK repeat 332..363 CDD:293786 9/33 (27%)
Ank_2 337..428 CDD:289560 28/102 (27%)
ANK 360..485 CDD:238125 38/133 (29%)
ANK repeat 365..395 CDD:293786 9/32 (28%)
ANK repeat 398..427 CDD:293786 9/28 (32%)
ANK repeat 431..462 CDD:293786 10/30 (33%)
Ank_2 436..526 CDD:289560 29/93 (31%)
ANK repeat 464..494 CDD:293786 11/29 (38%)
ANK 491..616 CDD:238125 31/132 (23%)
ANK repeat 496..527 CDD:293786 9/32 (28%)
Ank_2 501..592 CDD:289560 27/96 (28%)
ANK repeat 529..560 CDD:293786 9/32 (28%)
ANK 557..682 CDD:238125 34/134 (25%)
ANK repeat 562..590 CDD:293786 10/29 (34%)
Ank_5 582..636 CDD:290568 11/54 (20%)
ANK repeat 595..625 CDD:293786 6/30 (20%)
ANK repeat 628..657 CDD:293786 12/28 (43%)
Ank_2 633..723 CDD:289560 26/112 (23%)
ANK repeat 661..691 CDD:293786 6/36 (17%)
ANK 692..812 CDD:238125 32/173 (18%)
ANK repeat 693..724 CDD:293786 8/38 (21%)
Ank_2 698..788 CDD:289560 24/135 (18%)
ANK repeat 726..755 CDD:293786 11/43 (26%)
ANK repeat 759..788 CDD:293786 6/51 (12%)
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
sel-15NP_001366799.1 ANKYR 3..217 CDD:223738 45/160 (28%)
ANK repeat 115..147 CDD:293786 9/31 (29%)
PHA03095 128..>388 CDD:222980 85/294 (29%)
ANK repeat 153..180 CDD:293786 9/26 (35%)
ANK repeat 182..213 CDD:293786 10/30 (33%)
ANK repeat 215..246 CDD:293786 11/31 (35%)
ANK repeat 285..318 CDD:293786 9/32 (28%)
ANK repeat 320..353 CDD:293786 17/64 (27%)
ANKYR <323..458 CDD:223738 42/166 (25%)
ANK repeat 355..380 CDD:293786 9/24 (38%)
PKc_TNNI3K 522..780 CDD:270966 31/167 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.