DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and ANKAR

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_011508975.1	Gene:	ANKAR / 150709	HGNCID:	26350	Length:	1445	Species:	Homo sapiens

Alignment Length:	924	Identity:	175/924 - (18%)
Similarity:	297/924 - (32%)	Gaps:	333/924 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CELLRRGIKIDNATKKGNTAL-HIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDN 153
            |:.:..|:|  :|.::|.:|: |..|....          ::.:||....|:|..:.||..|..:
Human   495 CKSIPFGMK--SAVERGLSAVFHTFSRKTS----------SSTINVSDEAGYTIFHHAALHNRVS 547

  Fly   154 -CCRTLLAN---GANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDV 214
             .|:...||   .....::...|.||                             ||:||:...:
Human   548 IICQLCNANFKVNQRRFVTFSQGPTP-----------------------------LHLAAQACSL 583

  Fly   215 NAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLN---NKADVNYVAKHNITPLHVACK 276
            .....||....:..:..|.|:.|:|.||.|.||.|...|..   :..:....|::..|||.:|..
Human   584 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAAT 648

  Fly   277 WGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALH--- 338
            .|.|.....|...||........|...:|.:..:.|.||:|::::.|.|.|...|..:..|.
Human   649 SGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCES 713

  Fly   339 -----MAAQ-------------------GEHDEAAHLLLDNKAPVDEVTVDYL-------TALHV 372
                 ||..                   |......:||..:|..:...||..|       :|:|.
Human   714 YKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHA 778

  Fly   373 AAHCG----------------HVKVAKLLLDYKANPNARALNGFTPLHIACKKNRI-KMVELLIK 420
            ....|                |.:.|.:|.|.....|.         .:..|.|.| .::.||..
Human   779 LVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENK---------DVIAKYNGIPSLINLLNL 834

  Fly   421 HGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAAR--ANQADIIRI 483
            :..|:            :.:.|.||.::....::...|    :|....|....|  ::.:.:..:
Human   835 NIENV------------LVNVMNCIRVLCIGNENNQRA----VREHKGLPYLIRFLSSDSGLFNL 883

  Fly   484 LLRS-------------AKV--------DAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQS 527
            .|.|             |:|        ||||.||..|..||            |..|.:|:.|.
Human   884 FLNSFEDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVA------------LFKGKQISVQM 936

  Fly   528 NDKYSALHIAAKEG-------QENIVQVLLE-NGAENNAVTKKGFTPL------------HLACK 572
            ....:...:|:...       ::::.:.||: ..|....|.::|...|            ::|.:
Human   937 KGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQ 1001

  Fly   573 YGKQNVVQILLQNGASIDFQG--------------------KNDVTP----LHVAT--------- 604
            .|...::.:||...|.:.:.|                    .|.:.|    |.::|
Human  1002 IGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIAEGTLLSV 1066

  Fly   605 ------------HYNNPSIVEL------------LLKNGSSPNLCARNGQCAIHIAC-------- 637
                        |.:||...:|            ||:|..|||:   ..:.|..:||
Human  1067 IRAVGSICIGVAHTSNPVSQQLVVDENAFPVLIQLLRNHPSPNI---KVEVAFSLACIVLGNDVL 1128

  Fly   638 -----KKNYLEIAMQL-LQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLT 696
                 :....|.|..| |.|..:.:|..::|:: |.|.|....... .|:||.|:::
Human  1129 QKDLHENEGFEYADVLYLLHSTEKDICLRAGYA-LTLFAFNNRFQQ-YLILESGIMT-------- 1183

  Fly   697 PLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGY 761
                                 .:|.||                      |:|:..:.|.:
Human  1184 ---------------------ISIFER----------------------FLESTVETEKA----- 1200

  Fly   762 TPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVM-ESL-KIVTSTSVINSN 824
                .||.|  |:::..::|...             ||..:...||:: :|| .:.|||.|:..|
Human  1201 ----MAAFQ--IVVLAKVIRDMD-------------HITLSARGVTILVDSLYSVQTSTIVLTGN 1246

  Fly   825 IGAIEEKLKVMTPE 838
            :.|.....:...||
Human  1247 LIASLAHSRAGIPE 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	21/106 (20%)
		ANK repeat	72..103	CDD:293786	3/12 (25%)
		Ank_2	77..167	CDD:289560	18/81 (22%)
		ANK repeat	105..136	CDD:293786	6/31 (19%)
		ANK repeat	138..169	CDD:293786	8/34 (24%)
		ANK	204..320	CDD:238125	33/118 (28%)
		ANK repeat	204..231	CDD:293786	6/26 (23%)
		Ank_2	205..295	CDD:289560	27/92 (29%)
		ANK repeat	233..264	CDD:293786	10/33 (30%)
		ANK repeat	266..295	CDD:293786	9/28 (32%)
		ANK	294..419	CDD:238125	32/175 (18%)
		ANK repeat	299..330	CDD:293786	9/30 (30%)
		Ank_4	300..353	CDD:290365	15/79 (19%)
		ANK repeat	332..363	CDD:293786	7/57 (12%)
		Ank_2	337..428	CDD:289560	24/141 (17%)
		ANK	360..485	CDD:238125	24/150 (16%)
		ANK repeat	365..395	CDD:293786	9/52 (17%)
		ANK repeat	398..427	CDD:293786	6/29 (21%)
		ANK repeat	431..462	CDD:293786	4/30 (13%)
		Ank_2	436..526	CDD:289560	23/112 (21%)
		ANK repeat	464..494	CDD:293786	9/52 (17%)
		ANK	491..616	CDD:238125	34/201 (17%)
		ANK repeat	496..527	CDD:293786	8/30 (27%)
		Ank_2	501..592	CDD:289560	18/110 (16%)
		ANK repeat	529..560	CDD:293786	4/38 (11%)
		ANK	557..682	CDD:238125	37/207 (18%)
		ANK repeat	562..590	CDD:293786	7/39 (18%)
		Ank_5	582..636	CDD:290568	19/110 (17%)
		ANK repeat	595..625	CDD:293786	14/66 (21%)
		ANK repeat	628..657	CDD:293786	8/42 (19%)
		Ank_2	633..723	CDD:289560	17/103 (17%)
		ANK repeat	661..691	CDD:293786	8/29 (28%)
		ANK	692..812	CDD:238125	15/120 (13%)
		ANK repeat	693..724	CDD:293786	2/30 (7%)
		Ank_2	698..788	CDD:289560	11/89 (12%)
		ANK repeat	726..755	CDD:293786	2/28 (7%)
		ANK repeat	759..788	CDD:293786	5/28 (18%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ANKAR	XP_011508975.1	Ank_2	505..598	CDD:289560	24/131 (18%)
		ANK	527..658	CDD:238125	37/159 (23%)
		ANK repeat	533..567	CDD:293786	8/33 (24%)
		ANK repeat	570..600	CDD:293786	9/58 (16%)
		Ank_2	574..669	CDD:289560	27/94 (29%)
		ANK repeat	602..636	CDD:293786	10/33 (30%)
		ANK repeat	638..663	CDD:293786	7/24 (29%)
		ARM	<678..771	CDD:237987	18/92 (20%)
		armadillo repeat	703..727	CDD:293788	4/23 (17%)
		armadillo repeat	737..769	CDD:293788	7/31 (23%)
		ARM	738..851	CDD:237987	24/133 (18%)
		armadillo repeat	776..812	CDD:293788	6/35 (17%)
		armadillo repeat	816..850	CDD:293788	9/54 (17%)
		ARM	817..947	CDD:237987	30/157 (19%)
		armadillo repeat	858..898	CDD:293788	6/43 (14%)
		armadillo repeat	1005..1029	CDD:293788	4/23 (17%)
		armadillo repeat	1037..1075	CDD:293788	4/37 (11%)
		ARM	1039..1166	CDD:237987	26/130 (20%)
		armadillo repeat	1086..1121	CDD:293788	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900