Protein Alignment Ank and LOC1269287

DIOPT Version :10

• Sequence 1: NP_787122.1
• Gene: Ank / 43770
• FlyBaseID: FBgn0011747
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_061503100.1
• Gene: LOC1269287 / 1269287
• VectorBaseID: AGAMI1_012966
• Length: 1284
• Species: Anopheles gambiae
• Alignment Length: 1161
• Identity: 692/1161 - (59%)
• Similarity: 871/1161 - (75%)
• Gaps: 66/1161 - (5%)

  Fly    36 NDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKID 100
            :|...|||||||:|:::||::.|.  ...|||:||||||||||||:|||:|.:..|||.||..:|
Mosquito   141 SDGNTSFLRAARAGNLEKVLEHLK--NNIDINTCNANGLNALHLASKDGHVAVVTELLARGATVD 203

  Fly   101 NATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGANP 165
            .|||||||||||||||||.||:..||.:||:|||||.|||||||||||||||:..|.||:||||.
Mosquito   204 AATKKGNTALHIASLAGQEDVVKLLIKHNASVNVQSQNGFTPLYMAAQENHDSVVRLLLSNGANQ 268

  Fly   166 SLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIV 230
            ||:||||||||||||||||||:||||||:|.|||||||||||||||:||.||.|||::|.|.|:.
Mosquito   269 SLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLENDHNPDVT 333

  Fly   231 SKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDA 295
            |||||||||||:||||..:|.||:...|||||.|||||:|||||.||||.::..|||.:||.|::
Mosquito   334 SKSGFTPLHIASHYGNEAMANLLIQKGADVNYAAKHNISPLHVAAKWGKTNMVALLLEKGASIES 398

  Fly   296 ATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVD 360
            .|||||||||||:||||.:|:..||::.|||.:||||||:.|||||||||.:||.:||.::||||
Mosquito   399 KTRDGLTPLHCAARSGHEQVVDMLLERGAPISSKTKNGLAPLHMAAQGEHVDAARILLYHRAPVD 463

  Fly   361 EVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANI 425
            |||||||||||||||||||:|||||||..|:.|||||||||||||||||||||:||||:||||:|
Mosquito   464 EVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRIKVVELLLKHGASI 528

  Fly   426 GATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRS-AK 489
            .||||||||||||||||||:|||||||||:||.|:||:||||||||||||||.||||||||: |:
Mosquito   529 SATTESGLTPLHVASFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQ 593

  Fly   490 VDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGA 554
            |||.|||.|||||:||||||::|:||||||||:::|.:.|.|:||||||||||:.:..|||.|||
Mosquito   594 VDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDAVTKDMYTALHIAAKEGQDEVAAVLLNNGA 658

  Fly   555 ENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNG 619
            :.:|.||||||||||..|||...|.::||:..|.:|.||||.|||||||:||::.::..|||:.|
Mosquito   659 QIDATTKKGFTPLHLTAKYGHMKVAELLLEKSAPVDAQGKNGVTPLHVASHYDHQNVAMLLLEKG 723

  Fly   620 SSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEY 684
            :||:..|:||...:|||.:||.::||..||::.|..|..||:||:||||:||.|:.:|..||||
Mosquito   724 ASPHATAKNGHTPLHIAARKNQIDIANTLLKYEAQANAESKAGFTPLHLSAQEGHTEMSGLLLE- 787

  Fly   685 GVISAA-----AKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVK 744
               |.|     |:|||||:|:.|||..|.|:|:|::||||:...|:.||||||:|:|:|..::|:
Mosquito   788 ---SKANPDHQARNGLTPMHLCAQEDRVSVAQVLVKHGANLQAATKAGYTPLHVASHFGQANMVR 849

  Fly   745 FFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVM 809
            :.||...|:..|:.|||||||||:||||..|:|:||...|:|||:|.:|.|:|.||..|||::|:
Mosquito   850 YLIEQQVDVNASTGIGYTPLHQASQQGHCHIVNILLESNADPNAITNNGQTSLKIAQKLGYISVL 914

  Fly   810 ESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESCDD-LLDHNHYKYMATDDLKAN 873
            :|||.||..........: |||.:|:.||.|.||.:|||::|..:| :|....|:|:..|::| :
Mosquito   915 DSLKSVTDAKATPDQPPS-EEKYRVVAPEAMHETFMSDSEEEGGEDTVLSDQPYRYLTVDEMK-S 977

  Fly   874 YGQDQKNFDTT------------NTD-HDLTDVSVLNKKEILPNEMSCIE----LTEIGHKPDNV 921
            .|.|....|.|            :|| |.....::  :..|.|...|.::    .|:.   .||:
Mosquito   978 LGDDSLPIDVTRDERMDSNKMVQSTDSHQFPPTAL--EDSISPQHASMVQSGISATDF---TDNI 1037

  Fly   922 VIARSQVHLG------FLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVN 980
            .|.|.. |:|      ||||||||||||:|||.||:|||||||.::.|:|||||||||||||.::
Mosquito  1038 NIERHS-HVGKLHWKNFLVSFLVDARGGAMRGCRHSGVRIIVPARSAAQPTRITCRYVKPQRTMH 1101

  Fly   981 PPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREHN----- 1040
            ||||||||||.||:||:.||...||.|:.:||||:.:||..||||:||||||||:|||||
Mosquito  1102 PPPLMEGEALASRVLELGPVGAKFLGPVIMEVPHFASLRGKEREIVILRSDNGETWREHNIDMSD 1166

  Fly  1041 -LYKDIIG-----EDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGPDGGTVFSTAVP 1099
             :..|::.     |::.|.:|....||.|.||.:.|.:|||:||:|||||.|||:||.|.||.||
Mosquito  1167 EIIHDVLNECFEPEELAQLDELGGGRICRFVTYDFPQYFAVISRIRQEVHAIGPEGGMVSSTVVP 1231

  Fly  1100 QVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPV----VTVEPRRRKF 1151
            ||:|:||..||||||:||||   |:|.:..|    |||...:    |...|::::|
Mosquito  1232 QVQAVFPQGALTKKIKVGLQ---VNLFKPRK----GVAPEKLRKISVNHVPKKKRF 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_787122.1	ANKYR	20..337	CDD:440430	209/300 (70%)
		ANK repeat	72..103	CDD:293786	19/30 (63%)
		ANK repeat	105..136	CDD:293786	23/30 (77%)
		ANK repeat	138..169	CDD:293786	24/30 (80%)
		ANK repeat	204..231	CDD:293786	18/26 (69%)
		ANKYR	217..502	CDD:440430	215/285 (75%)
		ANK repeat	233..264	CDD:293786	21/30 (70%)
		ANK repeat	266..295	CDD:293786	18/28 (64%)
		ANK repeat	299..330	CDD:293786	19/30 (63%)
		ANK repeat	332..363	CDD:293786	21/30 (70%)
		ANK repeat	365..395	CDD:293786	24/29 (83%)
		ANK repeat	398..427	CDD:293786	25/28 (89%)
		ANK repeat	431..462	CDD:293786	26/30 (87%)
		ANK repeat	464..494	CDD:293786	26/30 (87%)
		ANK repeat	496..527	CDD:293786	22/30 (73%)
		ANKYR	510..797	CDD:440430	155/291 (53%)
		ANK repeat	529..560	CDD:293786	19/30 (63%)
		ANK repeat	562..590	CDD:293786	15/27 (56%)
		ANK repeat	595..625	CDD:293786	16/29 (55%)
		ANK repeat	628..657	CDD:293786	12/28 (43%)
		ANK repeat	661..691	CDD:293786	16/34 (47%)
		ANK repeat	693..724	CDD:293786	17/30 (57%)
		ANK repeat	726..755	CDD:293786	13/28 (46%)
		ANK repeat	759..788	CDD:293786	19/28 (68%)
		ZU5	930..1034	CDD:128514	74/109 (68%)
		UPA_2	1250..1378	CDD:375346
		Death_ank	1439..1521	CDD:260029
LOC1269287	XP_061503100.1	None