DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Asb7

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_536691.2	Gene:	Asb7 / 117589	MGIID:	2152835	Length:	318	Species:	Mus musculus

Alignment Length:	366	Identity:	90/366 - (24%)
Similarity:	140/366 - (38%)	Gaps:	136/366 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 LHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLT 434
            :..|...|.|...:.:|:...:||.|..||:|.||.:..:.:.:.|.:.::|||:
Mouse    18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD---------- 72

  Fly   435 PLHVASFMGCINIVIYLLQHEASADLPTIR----GETPLHLAARANQADIIRILLRSAKVDAIAR 495
                                      ||::    |.|.||.||...:|.|.|::|.|.....|
Mouse    73 --------------------------PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDI-- 109

  Fly   496 EGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVT 560
                                       |||:|||.::.||:||..|:::.|::|||..||.:.::
Mouse   110 ---------------------------INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLS 147

  Fly   561 KKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLC 625
            .||.|||.||....:.:.|:|||.:.|:||.|
Mouse   148 DKGTTPLQLAIIRERSSCVKILLDHNANIDIQ--------------------------------- 179

  Fly   626 ARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAA 690
              ||....:...|.|:....| .||.|||.|:               |.::
Mouse   180 --NGFLLRYAVIKSNHSYCRM-FLQRGADTNL---------------GRLE-------------- 212

  Fly   691 AKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPL 731
              :|.||||::|....||.:::|..:||:.:.|...|.|||
Mouse   213 --DGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	13/48 (27%)
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365
		ANK repeat	332..363	CDD:293786
		Ank_2	337..428	CDD:289560	16/57 (28%)
		ANK	360..485	CDD:238125	27/118 (23%)
		ANK repeat	365..395	CDD:293786	6/24 (25%)
		ANK repeat	398..427	CDD:293786	9/28 (32%)
		ANK repeat	431..462	CDD:293786	0/30 (0%)
		Ank_2	436..526	CDD:289560	16/93 (17%)
		ANK repeat	464..494	CDD:293786	11/33 (33%)
		ANK	491..616	CDD:238125	33/124 (27%)
		ANK repeat	496..527	CDD:293786	3/30 (10%)
		Ank_2	501..592	CDD:289560	31/90 (34%)
		ANK repeat	529..560	CDD:293786	12/30 (40%)
		ANK	557..682	CDD:238125	27/124 (22%)
		ANK repeat	562..590	CDD:293786	12/27 (44%)
		Ank_5	582..636	CDD:290568	8/53 (15%)
		ANK repeat	595..625	CDD:293786	0/29 (0%)
		ANK repeat	628..657	CDD:293786	10/28 (36%)
		Ank_2	633..723	CDD:289560	21/89 (24%)
		ANK repeat	661..691	CDD:293786	1/29 (3%)
		ANK	692..812	CDD:238125	16/40 (40%)
		ANK repeat	693..724	CDD:293786	11/30 (37%)
		Ank_2	698..788	CDD:289560	13/34 (38%)
		ANK repeat	726..755	CDD:293786	4/6 (67%)
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Asb7	NP_536691.2	ANK 1	13..42		5/23 (22%)
		PHA02875	21..>241	CDD:165206	85/351 (24%)
		ANK repeat	46..77	CDD:293786	11/66 (17%)
		ANK 2	46..75		10/64 (16%)
		ANK 3	80..109		11/28 (39%)
		ANK repeat	81..114	CDD:293786	15/61 (25%)
		ANK repeat	116..147	CDD:293786	12/30 (40%)
		ANK 4	116..145		12/28 (43%)
		ANK repeat	149..180	CDD:293786	15/65 (23%)
		ANK 5	149..178		13/28 (46%)
		ANK 6	180..208		10/28 (36%)
		ANK repeat	213..244	CDD:293786	11/30 (37%)
		ANK 7	213..242		11/28 (39%)
		PTZ00322	219..>272	CDD:140343	12/33 (36%)
		SOCS_ASB7	273..317	CDD:239696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810