DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Ank3

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_036011414.1	Gene:	Ank3 / 11735	MGIID:	88026	Length:	4691	Species:	Mus musculus

Alignment Length:	1481	Identity:	740/1481 - (49%)
Similarity:	986/1481 - (66%)	Gaps:	148/1481 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIK 98
            |::||..|:|||||:|.::|.:|::..|  .|:|.||.|||||||||:|:|:|::..|||:|...
Mouse    37 KKSDANASYLRAARAGHLEKALDYIKNG--VDVNICNQNGLNALHLASKEGHVEVVSELLQREAN 99

  Fly    99 IDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGA 163
            :|.|||||||||||||||||.:|:..|:...||||.||.||||||||||||||....|.||.|||
Mouse   100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGA 164

  Fly   164 NPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNAD 228
            :.||:|||||||||||:|||||::|::|||||.:||||||||||||:|:|..||.||||:|.|||
Mouse   165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNAD 229

  Fly   229 IVSK--------SGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTL 285
            :.||        ||||||||||||||:::||||||..|.|::.|:::|||||||.|.|..::..|
Mouse   230 VESKMVVNRATESGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 294

  Fly   286 LLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAH 350
            ||.|||||||.||||||||||.:||||.:|::.||.::||||:|||||||.||||.||:|.....
Mouse   295 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRSAPILSKTKNGLSPLHMATQGDHLNCVQ 359

  Fly   351 LLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMV 415
            |||.:..|||:||.||||||||||||||.||||:|||.||:|||:|||||||||||||||||:::
Mouse   360 LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAKALNGFTPLHIACKKNRIRVM 424

  Fly   416 ELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADI 480
            |||:||||:|.|.|||||||:|||:|||.:|||..|:.|.||.:...:||||.||:|||:.||::
Mouse   425 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 489

  Fly   481 IRILLR-SAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQEN 544
            :|.|:: .|:|:|.|::.|||||:::|||..:|:..|||.||..||.:...|:.||:||:||.|:
Mouse   490 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLAAREGHED 554

  Fly   545 IVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNP 609
            :...||::||..:..|||||||||:|.||||..|..:|||..||.|..||:.:||||||.||:|.
Mouse   555 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 619

  Fly   610 SIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGN 674
            .:..|||..|:||:..|:||...:|||.|||.::||..||::|||.|.:::.|.:.:|||||.|:
Mouse   620 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGH 684

  Fly   675 VDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYG 738
            ||||.|||.... ::.:.|:||||||:||||..|.|:::|:..||::..:|:.||||||:..|||
Mouse   685 VDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 749

  Fly   739 HLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNL 803
            ::.:|.|.:::.|.:...:..|||.|||||||||..|||:||::.|:||.||.:|||||.||..|
Mouse   750 NIKIVNFLLQHSAKVNAKTKNGYTALHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRL 814

  Fly   804 GYVTVMESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETL---------------LSD----SD 849
            ||::|:::||:||...:..:   .|.||.|:..||.|.|.|               |||    ||
Mouse   815 GYISVVDTLKVVTEEIMTTT---TITEKHKMNVPETMNEVLDMSDDEVRKASAPEKLSDGEYISD 876

  Fly   850 DESCD------------------DLLDHNHYKYMATDDLKANYGQDQKNFD-------------- 882
            .|..|                  |.:..:..||:...||| ..|.|....:
Mouse   877 GEEGDKCTWFKIPKVQEVLVKSEDAITGDTDKYLGPQDLK-ELGDDSLPAEGYVGFSLGARSASP 940

  Fly   883 --------TTNTDHDLTDVSVLNKKEILPNEMSCIELT------EIGHKP------DNVVIARSQ 927
                    |.|......| |::.::.::|::...:..|      .:.|..      |||.:..|.
Mouse   941 KISSDRSYTLNRSSYARD-SMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSP 1004

  Fly   928 VHLG-----------FLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNP 981
            ||.|           |||||:||||||||||.||:|:|||:||:.|..|||||||.||..::.||
Mouse  1005 VHSGCSSPLPQYDSRFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANP 1069

  Fly   982 PPLMEGEALVSRILEMSPVDGMFL---------------------------------SPITLEVP 1013
            ||::|||.|.||::||.|....||                                 .|:.:|:|
Mouse  1070 PPMVEGEGLASRLVEMGPAGAQFLGKLHLPTHPPPVNEGESLVSRILQLGPQGTKFIGPVIVEIP 1134

  Fly  1014 HYGTLRKNEREIIILRSDNGESWREHNL---YKDI------IGEDINQTEEFHSDRIVRIVTQNV 1069
            |:|::|..|||:|:|||:|||:|:||..   .:|:      :.|:::..||..:.||.||:|::.
Mouse  1135 HFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLAELLNGMDEELDSPEELGTKRICRIITKDF 1199

  Fly  1070 PHFFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQ 1134
            |.:||||||::||.:.|||:||.:.||.||.|:|.||..||||:||||||||.|......|:||.
Mouse  1200 PQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGN 1264

  Fly  1135 GVAVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATW 1199
            ....||:||||||||||||.||::||.|......:.|...|:   ::|.|||||||:||.:.|.|
Mouse  1265 KATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGD---ATPNLRLLCSITGGTSPAQW 1326

  Fly  1200 EDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRIS 1264
            ||:||:|||:|::|.|:|||.|||||||.||..:::...:|::||..|..||:..|||:|||...
Mouse  1327 EDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAKTND 1391

  Fly  1265 QTEAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKF 1329
            ..|:....||||||:.||||||||.|:|||:|:|||||:.:.:|::..||:.|:.|.|:||...|
Mouse  1392 PVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNF 1456

  Fly  1330 QPFCENRLSFSAHIKD--QEFPHGRICFMTYPMVGPDEVPLKPLCTLNISV 1378
            ..|.||||.||..|:|  || |.||:.|:..|.. ...:|...:|.|||::
Mouse  1457 YSFKENRLPFSIKIRDTSQE-PCGRLSFLKEPKT-TKGLPQTAVCNLNITL 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	84/124 (68%)
		ANK repeat	72..103	CDD:293786	17/30 (57%)
		Ank_2	77..167	CDD:289560	57/89 (64%)
		ANK repeat	105..136	CDD:293786	20/30 (67%)
		ANK repeat	138..169	CDD:293786	22/30 (73%)
		ANK	204..320	CDD:238125	77/123 (63%)
		ANK repeat	204..231	CDD:293786	18/26 (69%)
		Ank_2	205..295	CDD:289560	59/97 (61%)
		ANK repeat	233..264	CDD:293786	22/30 (73%)
		ANK repeat	266..295	CDD:293786	17/28 (61%)
		ANK	294..419	CDD:238125	90/124 (73%)
		ANK repeat	299..330	CDD:293786	19/30 (63%)
		Ank_4	300..353	CDD:290365	33/52 (63%)
		ANK repeat	332..363	CDD:293786	17/30 (57%)
		Ank_2	337..428	CDD:289560	66/90 (73%)
		ANK	360..485	CDD:238125	87/124 (70%)
		ANK repeat	365..395	CDD:293786	25/29 (86%)
		ANK repeat	398..427	CDD:293786	23/28 (82%)
		ANK repeat	431..462	CDD:293786	18/30 (60%)
		Ank_2	436..526	CDD:289560	45/90 (50%)
		ANK repeat	464..494	CDD:293786	16/30 (53%)
		ANK	491..616	CDD:238125	63/124 (51%)
		ANK repeat	496..527	CDD:293786	16/30 (53%)
		Ank_2	501..592	CDD:289560	46/90 (51%)
		ANK repeat	529..560	CDD:293786	12/30 (40%)
		ANK	557..682	CDD:238125	67/124 (54%)
		ANK repeat	562..590	CDD:293786	18/27 (67%)
		Ank_5	582..636	CDD:290568	27/53 (51%)
		ANK repeat	595..625	CDD:293786	15/29 (52%)
		ANK repeat	628..657	CDD:293786	15/28 (54%)
		Ank_2	633..723	CDD:289560	44/90 (49%)
		ANK repeat	661..691	CDD:293786	14/30 (47%)
		ANK	692..812	CDD:238125	62/119 (52%)
		ANK repeat	693..724	CDD:293786	15/30 (50%)
		Ank_2	698..788	CDD:289560	43/89 (48%)
		ANK repeat	726..755	CDD:293786	12/28 (43%)
		ANK repeat	759..788	CDD:293786	19/28 (68%)
		ZU5	930..1034	CDD:128514	63/147 (43%)
		Death_ank	1439..1521	CDD:260029
Ank3	XP_036011414.1	Ank_2	59..>304	CDD:423045	158/246 (64%)
		ANK repeat	73..104	CDD:293786	17/30 (57%)
		ANK repeat	106..137	CDD:293786	20/30 (67%)
		ANK repeat	139..164	CDD:293786	18/24 (75%)
		Ank_2	195..>437	CDD:423045	164/241 (68%)
		ANK repeat	205..240	CDD:293786	20/34 (59%)
		ANK repeat	242..273	CDD:293786	22/30 (73%)
		ANK repeat	275..306	CDD:293786	19/30 (63%)
		ANK repeat	308..333	CDD:293786	15/24 (63%)
		ANK repeat	341..372	CDD:293786	17/30 (57%)
		PHA03095	377..>665	CDD:222980	167/287 (58%)
		ANK repeat	377..405	CDD:293786	23/27 (85%)
		ANK repeat	407..438	CDD:293786	24/30 (80%)
		ANK repeat	440..471	CDD:293786	18/30 (60%)
		ANK repeat	473..504	CDD:293786	16/30 (53%)
		ANK repeat	506..537	CDD:293786	16/30 (53%)
		ANK repeat	539..568	CDD:293786	12/28 (43%)
		Ank_2	559..>796	CDD:423045	119/236 (50%)
		ANK repeat	572..601	CDD:293786	18/28 (64%)
		ANK repeat	605..634	CDD:293786	15/28 (54%)
		ANK repeat	638..669	CDD:293786	16/30 (53%)
		ANK repeat	671..702	CDD:293786	14/30 (47%)
		ANK repeat	704..735	CDD:293786	15/30 (50%)
		ANK repeat	737..768	CDD:293786	12/30 (40%)
		ANK repeat	770..798	CDD:293786	18/27 (67%)
		Ank_4	771..823	CDD:372654	33/51 (65%)
		ZU5	1018..1155	CDD:128514	62/136 (46%)
		UPA_2	1377..1506	CDD:375346	63/131 (48%)
		Herpes_BLLF1	<1542..1949	CDD:282904
		DUF2890	3296..>3412	CDD:314108
		Death_ank3	4113..4196	CDD:176781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4761
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56908
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.720