DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Ank1

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006509052.1	Gene:	Ank1 / 11733	MGIID:	88024	Length:	1950	Species:	Mus musculus

Alignment Length:	1573	Identity:	723/1573 - (45%)
Similarity:	982/1573 - (62%)	Gaps:	116/1573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCEL 92
            ||.|..|. ||..|||||||||::.|.:|.|..|  .|||:||.||||.||||:|:|:|.:..||
Mouse    54 NKMGFCKA-DAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVEL 115

  Fly    93 LRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRT 157
            |.:.|.::..|||||||||||:||||.:|:.:|:.|.||||.||..|||||||||||||....:.
Mouse   116 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 180

  Fly   158 LLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQ 222
            ||.||||.:::|||||||||||:||||:.:||.|:....:||||||||||||:.:|...|.:|||
Mouse   181 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 245

  Fly   223 HDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLL 287
            :|||.|::||:|||||||||||.|:::|.||||..|.||:..::.|||||:|.:.|.:.:..|||
Mouse   246 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 310

  Fly   288 CRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLL 352
            .|||:|:..|:|.|||||||:|:|||.:.:.||...|||..|||||||.:||||||:|.:...||
Mouse   311 DRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 375

  Fly   353 LDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVEL 417
            |...|.:|::|:|:||.|||||||||.:|||:|||..|.||:||||||||||||||||.|:::||
Mouse   376 LQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMEL 440

  Fly   418 LIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIR 482
            |:|.||:|.|.|||||||||||||||.:.||..|||..||.::..::.|||||:||||...::.:
Mouse   441 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 505

  Fly   483 ILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIV 546
            .||:: ||.:|.|::.|||||.|:|:|:..::.|||::||..|..:...::.||.||:||..:..
Mouse   506 YLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTA 570

  Fly   547 QVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSI 611
            ..|||..|....:|||||||||:|.||||..:.::||::.|..:..|||.:||||||.|:||..|
Mouse   571 LALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDI 635

  Fly   612 VELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVD 676
            |:|||..|.||:..|.||...:|||.|:|.:|:|..|||:|...|..|..|.:|||||||.|:.:
Mouse   636 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTE 700

  Fly   677 MVQLLLEYGVISAAA------KNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAA 735
            ||.|||     |..|      |:||||||:.:|||||.|:.:|::||..:...||.||||||:|:
Mouse   701 MVALLL-----SKQANGNLGNKSGLTPLHLVSQEGHVPVADVLIKHGVTVDATTRMGYTPLHVAS 760

  Fly   736 HYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIA 800
            |||::.||||.:::.||:...:.:||:||||||||||..|:.|||::.|:||.::.:|.|.|.||
Mouse   761 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIA 825

  Fly   801 SNLGYVTVMESLKIVT-STSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESCDDLLDHNHYKY 864
            ..|||::|.:.||:|| .|||:     .:.:|.::..||.:.| :|..|:||..      .|...
Mouse   826 KRLGYISVTDVLKVVTDETSVV-----LVSDKHRMSYPETVDE-ILDVSEDEGT------AHISI 878

  Fly   865 MATDDLKANYGQDQKNFDTTNTDHDLTDVSVLNKKEILP-------------------------- 903
            |. |:|..:..:.:.:.|.......|..|..|::....|
Mouse   879 MG-DELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRSEDQEQASKE 942

  Fly   904 -NEMSCIELTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTR 967
             :|.|.|..:......||:....|.||.||||||:||||||||||.||||:|:::||:.||.|||
Mouse   943 YDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTR 1007

  Fly   968 ITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDN 1032
            ||||.||||::..||||.|.|.|.|||:.:.|....||||:.:|:||:.:..:.:||:::|||:|
Mouse  1008 ITCRLVKPQKLNTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN 1072

  Fly  1033 GESWREH-----NLYKDII----GEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGP 1088
            |..|:||     ..|.|.|    .|::...||....|:.||:|.:.|.:|.::||:.|:...|||
Mouse  1073 GSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGP 1137

  Fly  1089 DGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKFHK 1153
            :||::.|..||.|:|.||.:|:|||:::.||||.|.....:||||.....||:|||||||||||:
Mouse  1138 EGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHR 1202

  Fly  1154 AITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFT 1218
            .|.|.||.|.:.|::..::  |.|:::|  ||||||:.||..:|.|||:||:|.|.:..:...||
Mouse  1203 PIGLRIPLPPSWTDNPRDS--GEGDTTS--LRLLCSVIGGTDQAQWEDITGTTKLIYANECANFT 1263

  Fly  1219 TTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKT 1283
            |.|||||||.||....:|...||.||..|..||:..|||||||.....|.:...:||||||.|||
Mouse  1264 TNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDAREGRLRCYCMTDDKVDKT 1328

  Fly  1284 LEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKD-QE 1347
            |||.|.|.|||:|||||||:...::.|.:||:||:.|..:|....||.|.||||:....::| ..
Mouse  1329 LEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVKVRDSSR 1393

  Fly  1348 FPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNENIV 1412
            .|.|.:.|:...|...|...:  ||.|||                 ::..|....|..:
Mouse  1394 EPGGFLSFLRKTMKYEDTQHI--LCHLNI-----------------TMPPCTKGSGAED------ 1433

  Fly  1413 FGVKEQQVKKIDITKACIMSSDIKLIHEADVI---LDDICSHLGSDWPLLANVLGVSQADIDLVK 1474
               :.:.:..:.:..:.:..|.:....:.|.:   :..|..|||..|..||..|..|..||:.::
Mouse  1434 ---RRRTLTPLTLRYSILSESRLGFTSDTDRVEMRMAVIREHLGLSWAELARELQFSVEDINRIR 1495

  Fly  1475 TEFLLNDSVKQSMAMLQLWLEHGGILTGNVLAEALY----KIGRSDIVEKSFKNAEFGTHQPEKV 1535
            .| ..|..:.||.|:|.||::..|   .|...|.||    .|.||:||..    .|....|...:
Mouse  1496 VE-NPNSLLDQSTALLTLWVDREG---ENAKMENLYTALRNIDRSEIVNM----LEGSGRQSRNL 1552

  Fly  1536 LPTAGIEKDGDYE 1548
            .|.   .:.||.|
Mouse  1553 KPE---RRHGDRE 1562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	78/124 (63%)
		ANK repeat	72..103	CDD:293786	15/30 (50%)
		Ank_2	77..167	CDD:289560	54/89 (61%)
		ANK repeat	105..136	CDD:293786	20/30 (67%)
		ANK repeat	138..169	CDD:293786	19/30 (63%)
		ANK	204..320	CDD:238125	64/115 (56%)
		ANK repeat	204..231	CDD:293786	15/26 (58%)
		Ank_2	205..295	CDD:289560	50/89 (56%)
		ANK repeat	233..264	CDD:293786	20/30 (67%)
		ANK repeat	266..295	CDD:293786	14/28 (50%)
		ANK	294..419	CDD:238125	78/124 (63%)
		ANK repeat	299..330	CDD:293786	17/30 (57%)
		Ank_4	300..353	CDD:290365	31/52 (60%)
		ANK repeat	332..363	CDD:293786	16/30 (53%)
		Ank_2	337..428	CDD:289560	58/90 (64%)
		ANK	360..485	CDD:238125	79/124 (64%)
		ANK repeat	365..395	CDD:293786	21/29 (72%)
		ANK repeat	398..427	CDD:293786	21/28 (75%)
		ANK repeat	431..462	CDD:293786	20/30 (67%)
		Ank_2	436..526	CDD:289560	44/90 (49%)
		ANK repeat	464..494	CDD:293786	14/30 (47%)
		ANK	491..616	CDD:238125	58/124 (47%)
		ANK repeat	496..527	CDD:293786	14/30 (47%)
		Ank_2	501..592	CDD:289560	38/90 (42%)
		ANK repeat	529..560	CDD:293786	10/30 (33%)
		ANK	557..682	CDD:238125	65/124 (52%)
		ANK repeat	562..590	CDD:293786	15/27 (56%)
		Ank_5	582..636	CDD:290568	27/53 (51%)
		ANK repeat	595..625	CDD:293786	18/29 (62%)
		ANK repeat	628..657	CDD:293786	13/28 (46%)
		Ank_2	633..723	CDD:289560	45/95 (47%)
		ANK repeat	661..691	CDD:293786	15/29 (52%)
		ANK	692..812	CDD:238125	62/119 (52%)
		ANK repeat	693..724	CDD:293786	15/30 (50%)
		Ank_2	698..788	CDD:289560	47/89 (53%)
		ANK repeat	726..755	CDD:293786	16/28 (57%)
		ANK repeat	759..788	CDD:293786	18/28 (64%)
		ZU5	930..1034	CDD:128514	60/103 (58%)
		Death_ank	1439..1521	CDD:260029	30/88 (34%)
Ank1	XP_006509052.1	ANK repeat	454..485	CDD:293786	20/30 (67%)
		ANK repeat	487..518	CDD:293786	14/30 (47%)
		ANK repeat	520..549	CDD:293786	13/28 (46%)
		ANK repeat	554..584	CDD:293786	10/29 (34%)
		ANK repeat	586..617	CDD:293786	15/30 (50%)
		Ank_2	597..>810	CDD:393464	108/217 (50%)
		ANK repeat	619..647	CDD:293786	17/27 (63%)
		ANK repeat	652..682	CDD:293786	14/29 (48%)
		ANK repeat	685..716	CDD:293786	16/35 (46%)
		ANK repeat	718..749	CDD:293786	15/30 (50%)
		ANK repeat	751..782	CDD:293786	16/30 (53%)
		ANK repeat	784..812	CDD:293786	17/27 (63%)
		Ank_4	785..837	CDD:372654	28/51 (55%)
		ZU5	970..1074	CDD:128514	60/103 (58%)
		UPA_2	1295..1424	CDD:375346	59/147 (40%)
		Death_ank1	1460..1543	CDD:260067	30/90 (33%)
		ANK repeat	65..93	CDD:293786	16/29 (55%)
		Ank_2	67..158	CDD:372319	54/92 (59%)
		ANK repeat	95..126	CDD:293786	15/30 (50%)
		ANK repeat	129..159	CDD:293786	19/29 (66%)
		PHA02876	<141..>486	CDD:165207	210/344 (61%)
		ANK repeat	161..192	CDD:293786	19/30 (63%)
		ANK repeat	194..218	CDD:293786	16/23 (70%)
		ANK repeat	227..254	CDD:293786	15/26 (58%)
		ANK repeat	257..287	CDD:293786	20/29 (69%)
		ANK repeat	289..320	CDD:293786	14/30 (47%)
		ANK repeat	322..353	CDD:293786	17/30 (57%)
		ANK repeat	355..386	CDD:293786	16/30 (53%)
		ANK repeat	391..419	CDD:293786	19/27 (70%)
		ANK repeat	421..452	CDD:293786	22/30 (73%)
		PHA02875	433..>643	CDD:165206	105/209 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848330
Domainoid	1	1.000	139	1.000	Domainoid score	I4761
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47562
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	LDO	PTHR24133
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720