DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and Ank2

DIOPT Version :10

Sequence 1:NP_787122.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_036018747.1 Gene:Ank2 / 109676 MGIID:88025 Length:4152 Species:Mus musculus


Alignment Length:1621 Identity:779/1621 - (48%)
Similarity:1044/1621 - (64%) Gaps:189/1621 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 NDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKID 100
            :|:..|||||||:|::.||:::|..|  .|||:||.|||||||||||:|:|.:..|||.||..:|
Mouse    46 SDSNASFLRAARAGNLDKVVEYLKGG--IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 108

  Fly   101 NATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGANP 165
            :|||||||||||||||||.:|:..|:...||:|.||.||||||||||||||.:..:.||.||||.
Mouse   109 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 173

  Fly   166 SLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIV 230
            |.:|||||||||||:||||::.||:|||||.:||||||||||||:|:|..:|.||||:|.|||:.
Mouse   174 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 238

  Fly   231 SK--------SGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLL 287
            ||        |||||||||||||||::||||||..|.|::.|::.|||||||.|.|..::..|||
Mouse   239 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 303

  Fly   288 CRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLL 352
            .||.:|||.|||||||||||:||||.:|::.||::.||:|.:||||||.|||||||:|.|....|
Mouse   304 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHL 368

  Fly   353 LDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVEL 417
            |..|||||:||:||||||||||||||.:|.|||||.:||||||||||||||||||||||||::||
Mouse   369 LQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL 433

  Fly   418 LIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIR 482
            |:|:||:|.|.|||||||:|||:|||.:|||:.|||:.||.|:..|||||.||:||||.|.:::|
Mouse   434 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 498

  Fly   483 ILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIV 546
            .|||: |.|||.|||.|||||:|||||...|:.|||||.|..:|.:.:.|:.|||:|:|||.::.
Mouse   499 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 563

  Fly   547 QVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSI 611
            .||||.||.::..|||||||||:|.|||..:|.::|||..|:.|..|||.:||||||.||:|..:
Mouse   564 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 628

  Fly   612 VELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVD 676
            ..|||:.|:||:..|:||...:|||.|||.::||..||.:||:.|.::|.|.:|||||:|.|:.|
Mouse   629 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTD 693

  Fly   677 MVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHL 740
            ||.|||:.|. |..:.|:|||.||:||||..|.|:.||.:|||:....|:.|||||.:|.|||::
Mouse   694 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNV 758

  Fly   741 DLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGY 805
            .:|.|.::..|::...:..|||||||||||||..|||:||:|.|.|||.|.:|||||.||..|||
Mouse   759 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 823

  Fly   806 VTVMESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETL-LSDSD---------------DESCD 854
            ::|:::||:||..  :.:....|.||.|:..||.|.|.| :||.:               .:|.|
Mouse   824 ISVVDTLKVVTEE--VTTTTTTITEKHKLNVPETMTEVLDVSDEEALKQFGDHFIDGEAFSDSGD 886

  Fly   855 DLLDHNHYKYMATDDLK---------------ANY--------GQDQKNFDTTNTDHDLT----- 891
            |.:..:..:|:..:|||               .||        ..|.....:::..|.|:     
Mouse   887 DTVTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYL 951

  Fly   892 -DVSVLNKKEILPN----------EMSCIELTEIGHKPDNVVIARSQVHLG------------FL 933
             |.::::...::|:          |.:...|:......|||.::.|.:|.|            ||
Mouse   952 RDSAMIDDTVVIPSHQVSALAKEAERNSYRLSWGTENLDNVALSSSPIHSGRSSPCLDRDNSSFL 1016

  Fly   934 VSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVN------------------ 980
            |||:||||||:|||.||||:|||:||:.|..|||:|||.||..|:..                  
Mouse  1017 VSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVG 1081

  Fly   981 ---------------PPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRS 1030
                           ||||.|||:||||||::.|....||.|:.:|:||:..||..|||:::|||
Mouse  1082 PSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRS 1146

  Fly  1031 DNGESWREH--NLYKDIIGEDIN-------QTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVI 1086
            :||:||:||  :..:|.:.|.:|       ..|:....||.||:|::.|.:||||||::|:.::|
Mouse  1147 ENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLI 1211

  Fly  1087 GPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKF 1151
            ||:||.:.||.|.||:|:||..||||:||||||||.:......|:||.....||:||:|||||||
Mouse  1212 GPEGGVLSSTVVSQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKF 1276

  Fly  1152 HKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVT 1216
            ||.||::||.|||.::.|:|...|:    :|||||||||:||.|.|.|||:||:|||:||.:.|:
Mouse  1277 HKPITMTIPVPKASSDVMLNGFGGD----APTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVS 1337

  Fly  1217 FTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKED 1281
            |||.|||||||||||.|.::...|:::|..:..||:..|||:|||.....||:...|||||||.|
Mouse  1338 FTTNVSARFWLIDCRQIQESVAFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVD 1402

  Fly  1282 KTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKD- 1345
            |||||||.|.|||:|||:|||:.:.:|::..||:||:.|.|:.....|..|.||||.....::| 
Mouse  1403 KTLEQQENFSEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDT 1467

  Fly  1346 -QEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNE 1409
             || |.||:.||..|......|. :.:|.|||::......:..:::                ..|
Mouse  1468 TQE-PCGRLSFMKEPKSTRGLVH-QAICNLNITLPIYAKESESDQE----------------PEE 1514

  Fly  1410 NIVFGVKEQQVKKIDITKACIMSSDIKLIHEADVILDDICSHLGSDWPLLAN---VLGVSQADID 1471
            .|  |:..::..:.:.|:..::.                 |||.::.|:||:   :..||:...|
Mouse  1515 EI--GMTSEKNDETESTETSVLK-----------------SHLVNEVPVLASPDLLSEVSEMKQD 1560

  Fly  1472 LVKTEFLLNDSVKQSMAMLQLWLEHGGILTGNVLAEALYKIGRS------DIVEKSFKNAE 1526
            |:|...:|...|...              .|::..:.|.|.|..      :|||:..::.|
Mouse  1561 LIKMTAILTTDVSDK--------------AGSLKVKELAKAGEEEPGEPFEIVERVKEDLE 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_787122.1 ANKYR 20..337 CDD:440430 197/308 (64%)
ANK repeat 72..103 CDD:293786 19/30 (63%)
ANK repeat 105..136 CDD:293786 19/30 (63%)
ANK repeat 138..169 CDD:293786 21/30 (70%)
ANK repeat 204..231 CDD:293786 17/26 (65%)
ANKYR 217..502 CDD:440430 197/293 (67%)
ANK repeat 233..264 CDD:293786 23/30 (77%)
ANK repeat 266..295 CDD:293786 15/28 (54%)
ANK repeat 299..330 CDD:293786 19/30 (63%)
ANK repeat 332..363 CDD:293786 20/30 (67%)
ANK repeat 365..395 CDD:293786 24/29 (83%)
ANK repeat 398..427 CDD:293786 23/28 (82%)
ANK repeat 431..462 CDD:293786 20/30 (67%)
ANK repeat 464..494 CDD:293786 19/30 (63%)
ANK repeat 496..527 CDD:293786 19/30 (63%)
ANKYR 510..797 CDD:440430 149/287 (52%)
ANK repeat 529..560 CDD:293786 14/30 (47%)
ANK repeat 562..590 CDD:293786 16/27 (59%)
ANK repeat 595..625 CDD:293786 16/29 (55%)
ANK repeat 628..657 CDD:293786 14/28 (50%)
ANK repeat 661..691 CDD:293786 16/30 (53%)
ANK repeat 693..724 CDD:293786 16/30 (53%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 21/28 (75%)
ZU5 930..1034 CDD:128514 63/148 (43%)
UPA_2 1250..1378 CDD:375346 62/129 (48%)
Death_ank 1439..1521 CDD:260029 20/90 (22%)
Ank2XP_036018747.1 ANKYR 37..386 CDD:440430 219/341 (64%)
ANK repeat 80..111 CDD:293786 19/30 (63%)
ANK repeat 113..144 CDD:293786 19/30 (63%)
ANK repeat 146..171 CDD:293786 17/24 (71%)
Ank_4 149..200 CDD:372654 35/50 (70%)
Ank_4 209..270 CDD:372654 40/60 (67%)
ANK repeat 212..247 CDD:293786 19/34 (56%)
ANK repeat 249..280 CDD:293786 23/30 (77%)
ANK repeat 282..313 CDD:293786 17/30 (57%)
ANK repeat 315..345 CDD:293786 19/29 (66%)
ANKYR 329..617 CDD:440430 182/287 (63%)
ANK repeat 348..379 CDD:293786 20/30 (67%)
ANK repeat 381..411 CDD:293786 24/29 (83%)
ANK repeat 414..445 CDD:293786 24/30 (80%)
ANK repeat 447..478 CDD:293786 20/30 (67%)
ANK repeat 480..511 CDD:293786 19/30 (63%)
ANK repeat 513..542 CDD:293786 18/28 (64%)
ANK repeat 546..571 CDD:293786 12/24 (50%)
ANKYR 566..831 CDD:440430 140/264 (53%)
ANK repeat 579..604 CDD:293786 15/24 (63%)
ANK repeat 612..643 CDD:293786 16/30 (53%)
ANK repeat 645..676 CDD:293786 15/30 (50%)
ANK repeat 678..707 CDD:293786 16/28 (57%)
ANK repeat 711..742 CDD:293786 16/30 (53%)
ANK repeat 744..775 CDD:293786 12/30 (40%)
ANK repeat 777..806 CDD:293786 21/28 (75%)
ZU5 1013..1150 CDD:128514 62/136 (46%)
UPA_2 1371..1500 CDD:375346 62/130 (48%)
PHA03307 1823..>2031 CDD:223039
PTZ00449 <2261..2668 CDD:185628
PHA03307 3210..>3537 CDD:223039
Death_ank2 3595..3678 CDD:260066
Blue background indicates that the domain is not in the aligned region.

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