DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and ankrd2

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_021336623.1	Gene:	ankrd2 / 101886079	ZFINID:	ZDB-GENE-090313-383	Length:	303	Species:	Danio rerio

Alignment Length:	301	Identity:	87/301 - (28%)
Similarity:	132/301 - (43%)	Gaps:	48/301 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 ARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLL--LQHGAEINAQSNDKYSALH 535
            |||.:..|:       .|||.| ||          ||:::...|  :|....:...|:|  ....
Zfish    26 ARARKLGIL-------VVDAGA-EG----------GNVSVNQSLADIQDEERVRKISSD--LRRE 70

  Fly   536 IAAKEGQENIVQVLLENGAENNAVT-KKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTP 599
            |....|.|||:::..:.....|..| .|..|.:..|.:      .:..|:..|    |||.:|
Zfish    71 IVDLGGAENIIELCTQKKKIKNKTTLSKDITNVSGAVE------PEEFLKAAA----QGKMEV-- 123

  Fly   600 LHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFS 664
                        ||..|.:|..||.|....:.|:|.|..:|:.:|..:||..|||:|...:.|..
Zfish   124 ------------VERFLDDGGDPNTCDEFRKTALHRAALQNHTKIVEKLLDKGADINFKDRLGCR 176

  Fly   665 PLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGY 728
            .:|.|.:||::..:.:|.:.|. |:...|...:|||||.:.||..|.|.||:.|.||:.:...|.
Zfish   177 AVHWACRGGSLSALTVLQDRGADINVRDKLLSSPLHVATRTGHSDVVQHLLDSGININAKDWEGD 241

  Fly   729 TPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQ 769
            |.||.|..:....:||..|...||:::.:..|.|...|..|
Zfish   242 TVLHDAVRFNRYKIVKQLILAGADMQIKNAEGITATEQVKQ 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365
		ANK repeat	332..363	CDD:293786
		Ank_2	337..428	CDD:289560
		ANK	360..485	CDD:238125	4/11 (36%)
		ANK repeat	365..395	CDD:293786
		ANK repeat	398..427	CDD:293786
		ANK repeat	431..462	CDD:293786
		Ank_2	436..526	CDD:289560	14/54 (26%)
		ANK repeat	464..494	CDD:293786	7/20 (35%)
		ANK	491..616	CDD:238125	29/127 (23%)
		ANK repeat	496..527	CDD:293786	6/32 (19%)
		Ank_2	501..592	CDD:289560	18/93 (19%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		ANK	557..682	CDD:238125	34/125 (27%)
		ANK repeat	562..590	CDD:293786	5/27 (19%)
		Ank_5	582..636	CDD:290568	15/53 (28%)
		ANK repeat	595..625	CDD:293786	7/29 (24%)
		ANK repeat	628..657	CDD:293786	10/28 (36%)
		Ank_2	633..723	CDD:289560	33/90 (37%)
		ANK repeat	661..691	CDD:293786	8/30 (27%)
		ANK	692..812	CDD:238125	29/78 (37%)
		ANK repeat	693..724	CDD:293786	14/30 (47%)
		Ank_2	698..788	CDD:289560	27/72 (38%)
		ANK repeat	726..755	CDD:293786	10/28 (36%)
		ANK repeat	759..788	CDD:293786	4/11 (36%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ankrd2	XP_021336623.1	ANK	135..260	CDD:238125	43/124 (35%)
		ANK repeat	143..171	CDD:293786	11/27 (41%)
		ANK repeat	174..204	CDD:293786	8/29 (28%)
		ANK repeat	206..237	CDD:293786	14/30 (47%)
		ANK repeat	239..270	CDD:293786	10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000