DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and osbpl1a

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_017950540.1	Gene:	osbpl1a / 100127588	XenbaseID:	XB-GENE-1011513	Length:	974	Species:	Xenopus tropicalis

Alignment Length:	1024	Identity:	198/1024 - (19%)
Similarity:	325/1024 - (31%)	Gaps:	370/1024 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 LHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFT 401
            ||.|..|..:|...||..|:.....|.:|          |.....:.|              |:|
Frog    14 LHDARNGNLEEVRELLESNRKGQTVVNID----------CKGKSKSNL--------------GWT 54

  Fly   402 PLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGE 466
            |||:.|.....::|:.|:..||.:....:.|.||||.|:|.|..:||:.||::  .||...|.||
Frog    55 PLHLTCYFGHGQVVKDLLMAGAAVNVQNDMGDTPLHRAAFTGRKDIVMLLLEY--GADTTVINGE 117

  Fly   467 --------------TPLHLAARANQADIIRILLRSAKVDAIAR------------------EGQT 499
                          |.|..|.|..:..:..:||.:|:...|.|                  .|.|
Frog   118 GQTAKDMTHDKEIKTMLEAAQRTQEIKLEEMLLAAAREGNILRLSELLNKPKPPNINCTDQMGNT 182

  Fly   500 PLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGF 564
            |||.|:..|..:..:.||:.||::||::......:.:|.   |..|.|||      .:.|.|...
Frog   183 PLHCAAYRGLKHCALKLLKCGADVNARNKTNQRPIDLAQ---QLEIKQVL------QSRVVKHVL 238

  Fly   565 TPLH----LACKYGK---QNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSP 622
            ..|.    ..||..:   ..|..::|::|....:|.:.|...........:.:.....||:....
Frog   239 RNLQRFDGALCKSSRFFGWRVFWVVLEHGVISWYQKQADAINNTYRQGCKHLTQAVCTLKSTDRY 303

  Fly   623 NLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLH---LAA-------------- 670
            :...:....:||      |.:|..:.|:|..:.:...:|.|:..|   |.|
Frog   304 SFSVKCFDDSIH------YFKILPKNLKHTREYDAQQQSSFTTKHCDWLTAIEEHSAYSTHYCSQ 362

  Fly   671 -QGGNVDMVQLLLEYGVISAAAKNGLTPLH------------VAAQEGHVLVSQILLEHGANISE 722
             |..:.:..:|:| .|.:..:.:|..|.|.            :...||...:..|:|:....:||
Frog   363 DQLSDDEDEELVL-VGDLKQSLENAQTSLQRLNKEVSQFAGGLTKWEGAKDIDPIILQQLTEVSE 426

  Fly   723 RTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPN 787
            .:::.|..|:        :.:..|.:.:|                       :.||.|.|:...|
Frog   427 ASQDTYKALN--------NCLLLFTKQEA-----------------------VRNLKLEHEQEKN 460

  Fly   788 ALTKDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDDES 852
            .:                  :.|:|:.:.:..      ..:|:.|...||.|  .|:|  |:||.
Frog   461 KI------------------LSEALQTLATEH------HELEKSLVKGTPPL--HTIL--SEDEF 497

  Fly   853 CDDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHDLTDVSVLNKKEILPNEMSCIELTEIGHK 917
            .|.:.|                         :::||.|:...                 |.....
Frog   498 YDAVSD-------------------------SDSDHSLSGFE-----------------TVTSSS 520

  Fly   918 PD---------NVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYV 973
            ||         .|.::..:.|            ||...|...||                    :
Frog   521 PDGSLNLSYNQQVSMSEEKKH------------GGGGGGSTSNG--------------------I 553

  Fly   974 KPQRVVNPPPLM-EGEALVSRILEMSPVDGMFLSPITLEV----------------PHYGTLRK- 1020
            |..|...|.|:. ..:..:..||.  ...||.||.||:.|                .|...:.|
Frog   554 KKHRTSLPSPMFSRNDFSIWSILR--KCIGMELSKITMPVIFNEPLSFLQRLSEYMEHTYLIHKA 616

  Fly  1021 NEREIIILR---------SDNGESW-REHNLYKDIIGEDINQTEEFHSDRIVRIVTQNVPHFFAV 1075
            |:....:.|         |.....| |....:..::||......|   |...|::::.|.|...|
Frog   617 NQCSDTVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRE---DLGFRLISEQVSHHPPV 678

  Fly  1076 VSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSP 1140
                 ...|..|.:...||.      .:|:|      |:               |..|:.|...|
Frog   679 -----SAFHAEGINNDFVFH------GSIYP------KL---------------KFWGKSVEAEP 711

  Fly  1141 --VVTVEPRRRKFHKAITLSIPAPKACTNSMVNA-----CYGN---------------------- 1176
              ::|:|..:.|  :|.|.:  .|..|.::::..     .|||
Frog   712 KGIITLELLKHK--EAYTWT--NPTCCVHNIIVGKLWIEQYGNMEITNHKTGEKCILNFKPSRLF 772

  Fly  1177 --------GNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTF 1217
                    |.....:.:.|||:.|     .|      |...:..|..||
Frog   773 DKELHKVEGYIQDKSKKKLCSLYG-----KW------TECLYTTDPATF 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	19/81 (23%)
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365	6/15 (40%)
		ANK repeat	332..363	CDD:293786	8/25 (32%)
		Ank_2	337..428	CDD:289560	22/90 (24%)
		ANK	360..485	CDD:238125	35/138 (25%)
		ANK repeat	365..395	CDD:293786	3/29 (10%)
		ANK repeat	398..427	CDD:293786	10/28 (36%)
		ANK repeat	431..462	CDD:293786	14/30 (47%)
		Ank_2	436..526	CDD:289560	35/121 (29%)
		ANK repeat	464..494	CDD:293786	9/43 (21%)
		ANK	491..616	CDD:238125	31/149 (21%)
		ANK repeat	496..527	CDD:293786	13/30 (43%)
		Ank_2	501..592	CDD:289560	24/97 (25%)
		ANK repeat	529..560	CDD:293786	6/30 (20%)
		ANK	557..682	CDD:238125	25/149 (17%)
		ANK repeat	562..590	CDD:293786	6/34 (18%)
		Ank_5	582..636	CDD:290568	8/53 (15%)
		ANK repeat	595..625	CDD:293786	3/29 (10%)
		ANK repeat	628..657	CDD:293786	6/28 (21%)
		Ank_2	633..723	CDD:289560	23/119 (19%)
		ANK repeat	661..691	CDD:293786	9/47 (19%)
		ANK	692..812	CDD:238125	19/131 (15%)
		ANK repeat	693..724	CDD:293786	9/42 (21%)
		Ank_2	698..788	CDD:289560	15/101 (15%)
		ANK repeat	726..755	CDD:293786	4/28 (14%)
		ANK repeat	759..788	CDD:293786	4/28 (14%)
		ZU5	930..1034	CDD:128514	23/130 (18%)
		Death_ank	1439..1521	CDD:260029
osbpl1a	XP_017950540.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910