Protein Alignment pan and TCF7L1

DIOPT Version :10

• Sequence 1: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_006712172.1
• Gene: TCF7L1 / 83439
• HGNCID: 11640
• Length: 589
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 182/707 - (25%)
• Similarity: 270/707 - (38%)
• Gaps: 225/707 - (31%)

  Fly   378 SNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESY 442
            :|:.::|.:......:.|..:|.|       ..:.|.|::      :|.||..::.|:|
Human    34 ANDELIPFQDEGGEEQEPSSDSAS-------AQRDLDEVK------SSLVNESENQSSS------ 79

  Fly   443 SDSVKSDCEESNSAPTCIWHSTRQTFRHKKD---------------------------------- 473
            |||      |:...|    ...|.||:..:|
Human    80 SDS------EAERRP----QPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPY 134

  Fly   474 -----VEPCSTAAEIILEYASLS--SSSNIETSRLLTSA--SNLTDVTEN-YNVTTQLPIVFNYN 528
                 :.|......:.:::..|.  ||:.::.:|..:.|  ||...|.:: :::....|::...|
Human   135 LSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSN 199

  Fly   529 RESSAESIVT--DPLLVPEFSTAPSTPSTGSNS---GCSTGMVSGI---FGLSQNRRKQRL---- 581
            ...|..|..|  .|.:.|:.:..|..|.....|   ..|.|.|..|   .|....::.|.:
Human   200 DHFSPGSPPTHLSPEIDPKTAGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLP 264

  Fly   582 ---ARH-IETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSANASLTAQ 642
               .|| ...|..|:..|:.:.......:     .:|:...|||..:.|      .:..:.:..|
Human   265 PGGFRHPYPALAMNASMSSLVSSRFSPHM-----VAPAHPGLPTSGIPH------PAIVSPIVKQ 318

  Fly   643 ELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETT- 706
            |                             .||..|                |.|.|.:|..|.
Human   319 E-----------------------------PAPPSL----------------SPAVSVKSPVTVK 338

  Fly   707 -NDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQE 770
             .::||||:||||||||||||||||||||||||||||||||||||:||.||||||:||||.||:|
Human   339 KEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKE 403

  Fly   771 RQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKC 835
            ||||.:|||.||||||||   ||||||:::..:.:......         |:::.....:.||.|
Human   404 RQLHSQLYPTWSARDNYG---KKKKRKREKQLSQTQSQQQV---------QEAEGALASKSKKPC 456

  Fly   836 IRYMEALNGNGPAED--GSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQS 898
            ::|:       |.|.  .|....|||.|.                                 :.:
Human   457 VQYL-------PPEKPCDSPASSHGSMLD---------------------------------SPA 481

  Fly   899 MPSPGCLSGLSSLQSPSTTMS-LASPLNMNANSATNVIFPASSNALLIVGA---------DQPTA 953
            .||    :.|:|..:|:.|.| .|.||::.....|.......|.|.|...|         .||..
Human   482 TPS----AALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPL 542

  Fly   954 QQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSH 1010
            ..||..:     .|..|:.:::.|:     .|.|......|...|.:.:.|..:.:|
Human   543 LSRPLPL-----GSMPTALLASPPS-----FPATLHAHQALPVLQAQPLSLVTKSAH 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	HMG-box_TCF7-like	713..791	CDD:438812	67/77 (87%)
TCF7L1	XP_006712172.1	CTNNB1_binding	30..251	CDD:462440	44/245 (18%)
		HMG-box_TCF7-like	346..421	CDD:438812	65/74 (88%)