DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pan and TCF7L2

DIOPT Version :9

Sequence 1:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001354872.1	Gene:	TCF7L2 / 6934	HGNCID:	11641	Length:	619	Species:	Homo sapiens

Alignment Length:	781	Identity:	229/781 - (29%)
Similarity:	316/781 - (40%)	Gaps:	243/781 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 LIDIK---KKLDNLSDSSGKFRKRLSVRQSHI---EVNNGSNSALEESVR---RQLNGNRKSIEN 325
            ||..|   ::.:..|::|...|....|:.|.:   |.|..|:|..|...|   |..:...||.|:
Human    18 LISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRES 82

  Fly   326 LLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYTSTPTHTIMALAAIALSNESILP 384
            |.|..||                        :||      .|...|...|..|.:..|.|.|:.|
Human    83 LEEAAKR------------------------QDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSP 123

  Fly   385 QKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESYSDSVKSD 449
                                    ..:||                 ...|.||.:.:|
Human   124 ------------------------TARTL-----------------HFQSGSTHYSAY------- 140

  Fly   450 CEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEII-LEYASLSSSSNIETSRLLTSA---SNLTD 510
                            :|..|:..|:.......:: ::..||.|...::.:|..:.|   ||...
Human   141 ----------------KTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVP 189

  Fly   511 VTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGSNSGCSTGMVSGIFGLSQN 575
            |.::.:....|..:..|:.|...      |...|....|...|.||.........:|..:.||..
Human   190 VVQHPHHVHPLTPLITYSNEHFT------PGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPG 248

  Fly   576 RRKQ----------RLARHIETLTTNSFKS--------NAIRGNVDNEITNQLKTSPSIRALPTE 622
            ...|          :..:.:..:||..|:.        ||........:.      |....|.|.
Human   249 TVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMV------PPHHTLHTT 307

  Fly   623 NVSH--LITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTK 685
            .:.|  ::|.|:.        ||.|            |.:.||:
Human   308 GIPHPAIVTPTVK--------QESS------------QSDVGSL--------------------- 331

  Fly   686 HMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGR 750
                   |:|..|.::.:|   :||||||||||||||||||||||||||||||||||||||||||
Human   332 -------HSSKHQDSKKEE---EKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGR 386

  Fly   751 RWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNN------ 809
            |||.||||||:||||.||:||||||:||||||||||||   ||||||:|:...::..::
Human   387 RWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG---KKKKRKRDKQPGETNEHSECFLNP 448

  Fly   810 ------------MKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLS 862
                        .||||||||||||:.||.||||||||:||::.        :|||.....|..|
Human   449 CLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQG--------EGSCLSPPSSDGS 505

  Fly   863 DDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSM-PSPGCLSGLSSLQSPSTTMSLASPLNM 926
            ..|......:.|    ||.....|.:.|.::.|:.|: |.|  |:.| |:..|...:.||
Human   506 LLDSPPPSPNLL----GSPPRDAKSQTEQTQPLSLSLKPDP--LAHL-SMMPPPPALLLA----- 558

  Fly   927 NANSATNVIFPASSNALLIVGA-DQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSST-VSPVTCM 989
               .||:     .::||...|| |.|.|..:|...|:| .:..||||:.:..:.:.| ..|::.:
Human   559 ---EATH-----KASALCPNGALDLPPAALQPAAPSSS-IAQPSTSSLHSHSSLAGTQPQPLSLV 614

  Fly   990 T 990
            |
Human   615 T 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	65/70 (93%)
TCF7L2	NP_001354872.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		24/101 (24%)
		CTNNB1-binding. /evidence=ECO:0000250	1..53		8/34 (24%)
		CTNNB1_binding	17..259	CDD:400583	62/334 (19%)
		Mediates interaction with MAD2L2. /evidence=ECO:0000269\|PubMed:19443654	201..395		81/256 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..350		15/82 (18%)
		SOX-TCF_HMG-box	353..420	CDD:238684	61/66 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..441		12/23 (52%)
		Nuclear localization signal. /evidence=ECO:0000255	425..430		4/4 (100%)
		Promoter-specific activation domain	459..505		28/53 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..547		15/57 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..619		13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I5013
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4297
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm42264
orthoMCL	1	0.900	-	-		OOG6_107890
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2732
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790