DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pan and TCF7

DIOPT Version :9

Sequence 1:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006714741.1	Gene:	TCF7 / 6932	HGNCID:	11639	Length:	460	Species:	Homo sapiens

Alignment Length:	156	Identity:	102/156 - (65%)
Similarity:	117/156 - (75%)	Gaps:	19/156 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 PYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLK 739
            |:|.::  ||:           |:|...||.    |||.|||||||||||||||||||:||||||
Human   278 PFDRNL--KTQ-----------AESKAEKEA----KKPTIKKPLNAFMLYMKEMRAKVIAECTLK 325

  Fly   740 ESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTD 804
            ||||||||||||||.||||||:||||.||:||||||:||||||||||||...::.:.|...||||
Human   326 ESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTD 390

  Fly   805 SGGNNMKKCRARFGLDQQSQWCKPCR 830
            .|  :.|||||||||:||:.||.|||
Human   391 PG--SPKKCRARFGLNQQTDWCGPCR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	63/70 (90%)
TCF7	XP_006714741.1	CTNNB1_binding	20..212	CDD:285538
TCF7	XP_006714741.1	SOX-TCF_HMG-box	300..370	CDD:238684	63/69 (91%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I5013
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm42264
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.870