DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pan and Tcf7l2

DIOPT Version :9

Sequence 1:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_038946142.1	Gene:	Tcf7l2 / 679869	RGDID:	1583621	Length:	674	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	237/817 - (29%)
Similarity:	338/817 - (41%)	Gaps:	263/817 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 REQKNI--------LIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGSNSALEESVR---RQLN 317
            :|:||.        |.|:|..|.|.|                 |.|..|:|..|...|   |..:
  Rat    27 QEEKNSENSSAERDLADVKSSLVNES-----------------ETNQNSSSDSEAERRPPPRSES 74

  Fly   318 GNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYTSTPTHTIMALAAIA 376
            ...||.|:|.|..||                        :||      .|...|...|..|.:..
  Rat    75 FRDKSRESLEEAAKR------------------------QDGGLFKGPPYPGYPFIMIPDLTSPY 115

  Fly   377 LSNESILP-------QKTNAVHSKIPDVESESDF-FLTSAKPKTLVEIEDIILQLASSVNMHQS- 432
            |.|.|:.|       |..:..:|....:|.:... :|....|  |::::      |.|:...|:
  Rat   116 LPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAIQYLQMKWP--LLDVQ------AGSLQSRQAL 172

  Fly   433 SSASTPHESYSDSVKSD---CEESNSAP-----------TCIWHSTRQTFRHKKDVEPCSTAAEI 483
            ..|.:|  |.:..|:|.   |.:.::.|           |.::..|:.:...:|..||.
  Rat   173 KDARSP--SPAHIVQSPLPCCTQGHACPHFYTPSDFTVSTQVFRDTKSSHSLQKVGEPW------ 229

  Fly   484 ILEYASLSSSSNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFST 548
            .||                   ||...|.::.:....|..:..|:.|...      |...|....
  Rat   230 FLE-------------------SNKVPVVQHPHHVHPLTPLITYSNEHFT------PGNPPPHLP 269

  Fly   549 APSTPSTGSNSGCSTGMVSGIFGLSQNRRKQ----------RLARHIETLTTNSFK-----SNAI 598
            |...|.||.........:|..:.||.....|          :..:.:..:||..|:     :..:
  Rat   270 ADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTV 334

  Fly   599 RGNVDNEITNQLKTS--PSIRALPTENVSH--LITKTLSSANASLTAQELSITNLFKERLCALQG 659
            ..::.:.::::....  |....|.|..:.|  ::|.|:.        ||.|            |.
  Rat   335 NASMSSFLSSRFPPHMVPPHHTLHTTGIPHPAIVTPTVK--------QESS------------QS 379

  Fly   660 NAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLY 724
            :.||:                            |:|..|.::.:|   :||||||||||||||||
  Rat   380 DVGSL----------------------------HSSKHQDSKKEE---EKKKPHIKKPLNAFMLY 413

  Fly   725 MKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGY 789
            |||||||||||||||||||||||||||||.||||||:||||.||:||||||:||||||||||||
  Rat   414 MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG- 477

  Fly   790 VSKKKKRKKDRSTTDSGGNN------------------MKKCRARFGLDQQSQWCKPCRRKKKCI 836
              ||||||:|:...::..::                  .||||||||||||:.||.||||||||:
  Rat   478 --KKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCV 540

  Fly   837 RYMEALNGNG-----PAEDGSCFDE-----HGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDED 891
            ||::   |.|     |:.|||..|.     |                   ..||..:..|.:.|.
  Rat   541 RYIQ---GEGSCLSPPSSDGSLLDSPPPSPH-------------------LLGSPPQDAKSQTEQ 583

  Fly   892 SESLNQSM-PSPGCLSGLSSLQSPSTTMSLASPLNMNANSATNVIFPASSNALLIVGA-DQPTAQ 954
            ::.|:.|: |.|  |:.||.:..|        |..:.|.:|     ...::||...|| |.|.|.
  Rat   584 TQPLSLSLKPDP--LAHLSMMPPP--------PALLLAEAA-----HGKASALCPNGALDLPPAT 633

  Fly   955 QRPTLVSTSGSSSGSTSSISTTPNTSST-VSPVTCMT 990
            .:|::|.:|..:..||||:.:..:.:.| ..|::.:|
  Rat   634 LQPSMVPSSSLAQPSTSSLHSHNSLAGTQPQPLSLVT 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	65/70 (93%)
Tcf7l2	XP_038946142.1	CTNNB1_binding	17..307	CDD:400583	72/361 (20%)
Tcf7l2	XP_038946142.1	SOX-TCF_HMG-box	406..473	CDD:238684	61/66 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4867
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm46416
orthoMCL	1	0.900	-	-		OOG6_107890
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910