Protein Alignment pan and tcf7

DIOPT Version :10

• Sequence 1: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_031753653.1
• Gene: tcf7 / 395061
• XenbaseID: XB-GENE-855462
• Length: 488
• Species: Xenopus tropicalis
• Alignment Length: 701
• Identity: 192/701 - (27%)
• Similarity: 270/701 - (38%)
• Gaps: 272/701 - (38%)

  Fly   263 IREQ---KNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGSNSALEESVRRQLNGNRKSIE 324
            |||.   :..|.|:|..|.|.|:.|...|    |.:||           .|::||.
 Frog    31 IRESAFTERDLADLKSSLVNESEVSSHPR----VPESH-----------PEAMRRT--------- 71

  Fly   325 NLLEEVKRLYNQWSSAELYYVRSL---QRLGLPSEEDGEYTST--PTHTIMALAAIALSNESILP 384
                         ..|:|.|...|   ...|:..:::|.|..:  |::..:.|:...|||.|:
 Frog    72 -------------QDAQLVYQDKLTDHMEDGVKHQDEGMYKGSGYPSYPFLMLSDPYLSNGSV-- 121

  Fly   385 QKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVN-MHQSSSASTPHESYSDSVKS 448
               :|:.||:|                        ::|.:..|: :...::.|..|.|:|..:.:
 Frog   122 ---SALSSKVP------------------------VVQPSHGVHPLIPYNNESFSHGSHSTHLPA 159

  Fly   449 DCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRLLTSASNLTDVTE 513
            |..:....             |:    |..||
 Frog   160 DLNQKQGV-------------HR----PAQTA--------------------------------- 174

  Fly   514 NYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGSNS-------GCSTGMVSGIFG 571
              ::.|..|:                    |.......:||.|..|       .|         |
 Frog   175 --DIPTFYPL--------------------PSGGVGQISPSVGWQSQPVYPIPSC---------G 208

  Fly   572 LSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSAN 636
            ..|                 .:.:....|...:...:.|..|||:.   |..:.|
 Frog   209 FRQ-----------------PYSATLSSGPSYSRFPHPLMLSPSMH---TTGIPH---------- 243

  Fly   637 ASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNE 701
                                             |.| .|:.   |:|    :::. :..|.:.:.
 Frog   244 ---------------------------------PAI-IPHS---GNK----DIDC-YERNMKPHS 266

  Fly   702 SKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEK 766
            ..:...:.|||.|||||||||||||||||||:||||||||||||||||||||.|||||||||||.
 Frog   267 EPKREREPKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQSKYYEL 331

  Fly   767 ARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRR 831
            ||:||||||:||||||||||||...::.:.|...|::|.|  :.|||||||||:||:.||.||||
 Frog   332 ARKERQLHMQLYPGWSARDNYGKRKRRTREKHQDSSSDPG--SPKKCRARFGLNQQTDWCGPCRR 394

  Fly   832 KKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLN 896
            |||||||::.        :|.|    ||.:|.|              |||      .|.....||
 Frog   395 KKKCIRYLQG--------EGRC----GSPVSSD--------------GSA------IDSPPSPLN 427

  Fly   897 QSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSAT---NVIFPASSNALL 944
            .....|......:.|.||:.::..|...:.:::|:|   ::|.|....|.|
 Frog   428 SRHSMPSSAYPTAKLSSPADSVQSAQSCSPSSSSSTVRSSLISPGYKGAFL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	HMG-box_TCF7-like	713..791	CDD:438812	70/77 (91%)
tcf7	XP_031753653.1	CTNNB1_binding	5..196	CDD:462440	50/302 (17%)
		HMG-box_TCF7-like	279..362	CDD:438812	70/82 (85%)