DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pan and Tcf7l1

DIOPT Version :9

Sequence 1:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_038963508.1	Gene:	Tcf7l1 / 312451	RGDID:	1311671	Length:	602	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	191/765 - (24%)
Similarity:	282/765 - (36%)	Gaps:	248/765 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 SDSSGKFRKRLSVRQSHIEVNNGSNSALEESVRRQLNGNRKSIE---NLLEEVKRLYNQWSSAEL 342
            |||:...|....|:.|.:..:...:|:.:....|:....|.:.:   :...||:|
  Rat    51 SDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAEVRR---------- 105

  Fly   343 YYVRSLQRLGLPSEEDGEYTSTPTHT----IMALAAIALSNESILPQKTNAVHSKIPDVESE--S 401
                         .:||.:...|.:.    :|                       |||:.|.  |
  Rat   106 -------------PQDGAFFKGPAYPGYPFLM-----------------------IPDLSSPYLS 134

  Fly   402 DFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQ 466
            :..|:....:|.::::..:|.:.||..:..:.|.|..| .|.|..:             | ....
  Rat   135 NGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAH-LYGDPAR-------------W-MVPP 184

  Fly   467 TFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRLLTSASNLTDVTEN-YNVTTQL-PIVFNYNR 529
            |||                                    ||...|.:: :::...| |::...|.
  Rat   185 TFR------------------------------------SNKVPVLQHPHHLQHPLTPLITYSND 213

  Fly   530 ESSAESIVT--DPLLVPEFSTAPSTPSTGSNS---GCSTGMVSGI---FGLSQNRRKQRL----- 581
            ..|..|..|  .|.:.|:.:..|..|.....|   ..|.|.|..|   .|....::.|.:
  Rat   214 HFSPASPPTHLSPEIDPKTAGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPP 278

  Fly   582 --ARH-IETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSANASLTAQE 643
              .|| ...|..|:..|:.:.......:     .:|:...|||..:.|      .:..:.:..||
  Rat   279 GGFRHPYPALAMNASMSSLVSSRFSPHM-----VAPAHPGLPTSGIPH------PAIVSPIVKQE 332

  Fly   644 LSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETT-- 706
                                         .||..|                |.|.|.:|..|.
  Rat   333 -----------------------------PAPPSL----------------SPAVSAKSPVTVKK 352

  Fly   707 NDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQER 771
            .::||||:||||||||||||||||||||||||||||||||||||:||.||||||:||||.||:||
  Rat   353 EEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKER 417

  Fly   772 QLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCI 836
            |||.:|||.||||||||   ||||||:::..:.:.....         .|:::.....:.||.||
  Rat   418 QLHAQLYPTWSARDNYG---KKKKRKREKQLSQTQSQQQ---------IQEAEGALVSKSKKPCI 470

  Fly   837 RYMEALNGNGPAED--GSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSM 899
            :|:       |.|.  .|....|||.|.                                 :.:.
  Rat   471 QYL-------PPEKPCDSPASSHGSTLD---------------------------------SPAT 495

  Fly   900 PSPGCLSGLSSLQSPSTTMS-LASPLNMNANSATNVIFPASSNALLIVGADQPTAQQ---RPTLV 960
            ||    :.|:|..:|:.|.| .|.||::.....|.......|.|.|...|....:.|   :|.|:
  Rat   496 PS----AALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKATASNSSQMGSQPPLL 556

  Fly   961 STSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSH 1010
            |.........:::.|:|.:    .|.|......|...|.:.:.|..:.:|
  Rat   557 SRPLPLGSMPTALLTSPPS----FPATLHAHQTLPVLQAQPLSLVTKSAH 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	61/70 (87%)
Tcf7l1	XP_038963508.1	CTNNB1_binding	28..264	CDD:400583	53/309 (17%)
Tcf7l1	XP_038963508.1	SOX-TCF_HMG-box	359..430	CDD:238684	61/70 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910