Protein Alignment pan and Tcf7l1

DIOPT Version :9

• Sequence 1: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001073290.1
• Gene: Tcf7l1 / 21415
• MGIID: 1202876
• Length: 599
• Species: Mus musculus
• Alignment Length: 763
• Identity: 188/763 - (24%)
• Similarity: 283/763 - (37%)
• Gaps: 247/763 - (32%)

  Fly   281 SDSSGKFRKRLSVRQSHIEVNNGSNSALEESVRRQLNGNRKSIE---NLLEEVKRLYNQWSSAEL 342
            |||:...|....|:.|.:..:...:|:.:....|:....|.:.:   :...||:|
Mouse    51 SDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAEVRR---------- 105

  Fly   343 YYVRSLQRLGLPSEEDGEYTSTPTHT----IMALAAIALSNESILPQKTNAVHSKIPDVESE--S 401
                         .:||.:...|.:.    :|                       |||:.|.  |
Mouse   106 -------------PQDGAFFKGPAYPGYPFLM-----------------------IPDLSSPYLS 134

  Fly   402 DFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESYSDSVK---SDCEESNSAPTCIWHS 463
            :..|:....:|.::::..:|.:.||..:..:.|.|..| .|.|..:   .....||..|
Mouse   135 NGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAH-LYGDPARWMVPPTFRSNKVP------ 192

  Fly   464 TRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRLLTSASNLTDVTENYNVTTQLP------ 522
               ..:|...:.|.:          .|.:.||...|    .||..|.::...:..|.:|
Mouse   193 ---VVQHPHHMHPLT----------PLITYSNDHFS----PASPPTHLSPEIDPKTGIPRPPHPS 240

  Fly   523 -IVFNYNRESSAESIVTDPL--LVPE-----FSTAPSTPSTGSNSGCSTGMVSGIFGLSQNRRKQ 579
             :...|.....|...:..||  |||:     :|..|                 |.|
Mouse   241 ELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPP-----------------GGF--------- 279

  Fly   580 RLARH-IETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSANASLTAQE 643
               || ...|..|:..|:.:.....:.:      :|:...|||..:.|                .
Mouse   280 ---RHPYPALAMNASMSSLVSSRFPHMV------APAHPGLPTSGIPH----------------P 319

  Fly   644 LSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTND 708
            ..::.:.|:...|         ..:.|.:.|...:::                     .||   :
Mouse   320 AIVSPIVKQEPAA---------PSLSPAVSAKSPVTV---------------------KKE---E 351

  Fly   709 KKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQL 773
            :||||:||||||||||||||||||||||||||||||||||||:||.||||||:||||.||:||||
Mouse   352 EKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQL 416

  Fly   774 HMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRY 838
            |.:|||.||||||||   ||||||:::..:.:.....         .|:::.....:.||.||:|
Mouse   417 HAQLYPTWSARDNYG---KKKKRKREKQLSQTQSQQQ---------IQEAEGALASKSKKPCIQY 469

  Fly   839 MEALNGNGPAED--GSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSMPS 901
            :       |.|.  .|....|||.|.                                 :.:.||
Mouse   470 L-------PPEKPCDSPASSHGSTLD---------------------------------SPATPS 494

  Fly   902 PGCLSGLSSLQSPSTTMS-LASPLNMNANSATNVIFPASSNALLIVGADQPTAQQ---RPTLVST 962
                :.|:|..:|:.|.| .|.||::.............|.|.|...|....:.|   :|.|:|.
Mouse   495 ----AALASPAAPAATHSEQAQPLSLTTKPEARAQLALHSAAFLSAKAAASNSSQMGSQPPLLSR 555

  Fly   963 SGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSH 1010
            ........:::.|:|.|    .|.|......|...|.:.:.|..:.:|
Mouse   556 PLPLGSMPAALLTSPPT----FPATLHAHQALPVLQAQPLSLVTKSAH 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	61/70 (87%)
Tcf7l1	NP_001073290.1	CTNNB1_binding	28..262	CDD:285538	49/280 (18%)
		SOX-TCF_HMG-box	356..427	CDD:238684	61/70 (87%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm57818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.870