Protein Alignment pan and Tcf7

DIOPT Version :10

• Sequence 1: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_030101626.1
• Gene: Tcf7 / 21414
• MGIID: 98507
• Length: 516
• Species: Mus musculus
• Alignment Length: 591
• Identity: 184/591 - (31%)
• Similarity: 240/591 - (40%)
• Gaps: 192/591 - (32%)

  Fly   437 TPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRL 501
            |....:.|.:....|:...||.|.....::|         ..:|..:::.|...|.:..
Mouse    91 TSQRLFPDKLPESLEDGLKAPECASGMYKET---------VYSAFNLLMPYPPASGAGQ------ 140

  Fly   502 LTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVP---EFSTAPSTPSTGSNSGCST 563
                          :...|.|:   :|:.......|  |.|.|   .||:...||:....|
Mouse   141 --------------HPQPQPPL---HNKPGQPPHGV--PQLSPLYEHFSSPHPTPAPADIS---- 182

  Fly   564 GMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLI 628
                         :||.:.|.::|...:.|.|               .||.|:..||
Mouse   183 -------------QKQGVHRPLQTPDLSGFYS---------------LTSGSMGQLP-------- 211

  Fly   629 TKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPY------DLSIGSKTKHM 687
             .|:|..:..|  ..||.:..:::...|.....|           |||      .|.:||.....
Mouse   212 -HTVSWPSPPL--YPLSPSCGYRQHFPAPTAAPG-----------APYPRFTHPSLMLGSGVPGH 262

  Fly   688 NLEAKHTS---------------NAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECT 737
            .....|.:               |.::....:...:.|||.|||||||||||||||||||:||||
Mouse   263 PAAIPHPAIVPSSGKQELQPYDRNLKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECT 327

  Fly   738 LKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRST 802
            ||||||||||||||||.||||||:||||.||:||||||:||||||||||||...::.:.|...||
Mouse   328 LKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQEST 392

  Fly   803 TDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDED 867
            ||.|  :.|||||||||:||:.||.|||||||||||:       |.| |.|.....|
Mouse   393 TDPG--SPKKCRARFGLNQQTDWCGPCRRKKKCIRYL-------PGE-GRCPSPVPS-------- 439

  Fly   868 DYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSAT 932
              ||..||.....|.     :|..|..|..|.|                |..||||:.
Mouse   440 --DDSALGCPRSPAP-----QDSPSYLLLPSFP----------------TELLASPVE------- 474

  Fly   933 NVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCL--G 995
                ||                  ||.       ||.:::: |.|...|..:|.:.:..|.:  .
Mouse   475 ----PA------------------PTF-------SGRSAAL-TLPAPKSPKTPHSTLQNPQIQQQ 509

  Fly   996 SSQERA 1001
            .||.:|
Mouse   510 ESQRQA 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pan	NP_726528.2	HMG-box_TCF7-like	713..791	CDD:438812	69/77 (90%)
Tcf7	XP_030101626.1	CTNNB1_binding	20..216	CDD:462440	34/199 (17%)
		HMG-box_TCF7-like	304..387	CDD:438812	69/82 (84%)