DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and AZF1

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	1039	Identity:	203/1039 - (19%)
Similarity:	320/1039 - (30%)	Gaps:	387/1039 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SPCINQHHP---------------------------TD--VSSSVTVPSIIP---TGGTSDSIKT 70
            :|.:||..|                           ||  ::|.:.:...:|   |||.|.....
Yeast    39 TPILNQSQPASSQPQHQQQRNESISYYTNFNQPRYSTDASINSFLNISDNVPVTSTGGPSSGGAY 103

  Fly    71 SIQPQICNENTLLGNAGHQHNHQPQHVHNI--------NVTGQPHDFHPAYRIPGYMEQLYSLQR 127
            |..|::...:|          |||..:..|        |:..|.......:|    .:|....|:
Yeast   104 SNLPRLSTSST----------HQPPDLSQIGRGFSIVNNLFPQQQQLQNQHR----QQQQQQQQQ 154

  Fly   128 TNSASSFHDPYVNCASAFHLAGLGLGSA-DFLGSRGLSSLGELHNAAVAAAAAGSLASTDF---- 187
            ::....|..|      :|.....|..|. .||.....:|.......:|   ..|.....||
Yeast   155 SHQQPPFKTP------SFSTGLTGSSSQYQFLPRNDNTSQPPSKRNSV---YLGPNDGPDFEFFS 210

  Fly   188 -------HFSVDGNRRLGSPRPP-----------------GGSIRASI----------------- 211
                   .|.....|...|.|||                 .|::..:.
Yeast   211 MQQSQQPQFQPSSRRESNSMRPPLLIPAATTKSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQ 275

  Fly   212 ------SRKRALSSSPYSDSFDI-----NSMIR----------FSP----NSLATIMNGSRGSSA 251
                  ||..:|..:|  :.||.     ||.:|          |.|    ||| ::.|.:.|...
Yeast   276 NPYFLSSRNNSLKFNP--EDFDFQFKRRNSFVRGTLDHSSQNAFIPESRLNSL-SVNNKANGDPV 337

  Fly   252 ASGSYGHI--------------------------------------------SATALN-PMSHVH 271
            |.....::                                            |||:.| |....|
Yeast   338 ADNVTNNMKGKSNEVDNDDGNDSSNNNNNNNNNNNNENNNDNNNDNNDNSINSATSTNIPNQEDH 402

  Fly   272 STR-----------LQQIQAHLLR-------ASAGLLNPMTPQQVAASGFSIG-HMPTSASLRVN 317
            |..           |::|:..|.:       .|:.:..|:....|......:. |:..|.
Yeast   403 SLASTDTTSNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEGLNKHIDESG----- 462

  Fly   318 DVHPNL------SDSHIQI-----TTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQP 371
             :.||:      .||.:.:     .|.|.::|| :...|...::.|...   |:.|..|:.....
Yeast   463 -MQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKD-NSTSAEGAAMANFSG---KEPPIPDISSVSD 522

  Fly   372 SSTS-GGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYDCAN 435
            .:|: .|..:|:......|...:.:...||  |...||:..|..:|        .:|
Yeast   523 DATNLIGATKVDQLMLIIQARKKGFTEKVN--TTQDGDLLFNQTMD--------ILP-------- 569

  Fly   436 ADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKA 500
                                        .:.|||..:.......|.:|  .:..:|....:.|..
Yeast   570 ----------------------------PKSELVGGVEKPKGTQNTRA--VKKHECPYCHRLFSQ 604

  Fly   501 QYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRA 565
            ...|.||:|.|.|.||..|.:  |.|.:::..||:||.|.|||||||:|:.  |.|.||...:.|
Yeast   605 ATHLEVHVRSHIGYKPFVCDY--CGKRFTQGGNLRTHERLHTGEKPYSCDI--CDKKFSRKGNLA 665

  Fly   566 KHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNS 630
            .|. .||...||::||...|.|.:|...:::.|          .|:.||. .||...::|.:.|.
Yeast   666 AHL-VTHQKLKPFVCKLENCNKTFTQLGNMKAH----------QNRFHKE-TLNALTAKLAEMNP 718

  Fly   631 RHNLQEHNIDSSPCSEDSHL-----------------GKMLGTSSPSIKSESDISSSNHHLVNGV 678
            ..|:        |..|...|                 ||.:||      .:|.|||..:|..:.:
Yeast   719 SENI--------PLEERQLLEYFASIYKNSNRGIKGRGKGVGT------KKSTISSPENHPASTI 769

  Fly   679 RASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGS---VLAR 740
                    .:|:..|.|...:|..|..:..               ||.::|:::..||   :...
Yeast   770 --------LNPNTNANNAIANDSENNGNPE---------------GNIDSSSNSNPGSHSMISPT 811

  Fly   741 QRFRGRLQTK--------GINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLP 797
            |:..|.||::        .:|||.       .||:..    :|...|               .||
Yeast   812 QKDMGTLQSQFIQNNFNNSVNSSN-------PSNQPI----INYNYT---------------TLP 850

  Fly   798 NTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQV 861
            ::.:|         .:|..||.:|......|:..|.....:.|:..|...........||..||
Yeast   851 HSRLG---------SSSSSNTNNNNSNFSVGAAPGVLMAPTTNNDFSFNLDQSNDNERSQQEQV 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	11/26 (42%)
		C2H2 Zn finger	519..541	CDD:275368	8/21 (38%)
		zf-H2C2_2	533..560	CDD:290200	16/26 (62%)
		C2H2 Zn finger	549..572	CDD:275368	7/22 (32%)
		C2H2 Zn finger	580..601	CDD:275368	6/20 (30%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	107/513 (21%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		C2H2 Zn finger	623..643	CDD:275368	8/21 (38%)
		C2H2 Zn finger	651..671	CDD:275368	7/22 (32%)
		C2H2 Zn finger	679..702	CDD:275368	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000