Protein Alignment ci and ZIC5

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_149123.3
• Gene: ZIC5 / 85416
• HGNCID: 20322
• Length: 639
• Species: Homo sapiens
• Alignment Length: 734
• Identity: 177/734 - (24%)
• Similarity: 246/734 - (33%)
• Gaps: 272/734 - (37%)

  Fly    10 FPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIPTGGTSDSIKTSIQP 74
            || |:.|....|:|.||.||               ||...|        .|.||
Human    87 FP-AHPEAPAAAARAAALVA---------------HPGAGS--------YPCGG----------- 116

  Fly    75 QICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYV 139
                     |::|.|.:..|.....:..|..|    |....|.....|.....|||...
Human   117 ---------GSSGAQPSAPPPPAPPLPPTPSP----PPPPPPPPPPALSGYTTTNSGGG------ 162

  Fly   140 NCASAFHLAGLGLG-SADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGS---- 199
                    ...|.| |.||:..|.||:      .|.|||..|:        .:.|.:|.|:
Human   163 --------GSSGKGHSRDFVLRRDLSA------TAPAAAMHGA--------PLGGEQRSGTGSPQ 205

  Fly   200 -PRPPGGSIRASISRKRALSSSPYSDSFDINSMIRF--------SPNSLATIMNG-------SRG 248
             |.||..|....||     :|..|:..........|        :|......:||       :..
Human   206 HPAPPPHSAGMFIS-----ASGTYAGPDGSGGPALFPALHDTPGAPGGHPHPLNGQMRLGLAAAA 265

  Fly   249 SSAASGSYG-------------HISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAA 300
            ::||:..||             |..|.|....:.:|......:..:|..|:|.        ..|.
Human   266 AAAAAELYGRAEPPFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAA--------AAAG 322

  Fly   301 SGFSIGH--------MPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAR 357
            .|..:.|        .|.:.:...:..||:|                    |.||.:.     .|
Human   323 PGPHLQHHAPPPAPPPPPAPAQHPHQHHPHL--------------------PGAAGAF-----LR 362

  Fly   358 EKKGPFKDVV---------------------PEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNN 401
            ..:.|.|..:                     |..|...:||.
Human   363 YMRQPIKQELICKWIDPDELAGLPPPPPPPPPPPPPPPAGGA----------------------- 404

  Fly   402 ITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQD 466
                                                                  :.|...|.|..
Human   405 ------------------------------------------------------KPCSKTFGTMH 415

  Fly   467 ELVKHINNDHI-QTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSR 530
            |||.|:..:|: ...:.:.||.||||.|..|||||:|.|:.|:|.||||||..|.|.||.|.::|
Human   416 ELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFAR 480

  Fly   531 LENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSL 595
            .||||.|.|:||||||:.||:.||.:.|:|:|||.|| :..|:::|||.||..||.|.||.||||
Human   481 SENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKH-SHVHTSDKPYYCKIRGCDKSYTHPSSL 544

  Fly   596 RKHVKTVH--------GAEFYAN-KKHKGLPLNDANSRLQQNNSRHNLQEHNID------SSPCS 645
            |||:| :|        |...|:: ....|.||:......:.::|..:.|..|::      :|...
Human   545 RKHMK-IHCKSPPPSPGPLGYSSVGTPVGAPLSPVLDPARSHSSTLSPQVTNLNEWYVCQASGAP 608

  Fly   646 EDSHLGKMLGTSSPSIKSE 664
            ...|.....||:|.:...|
Human   609 SHLHTPSSNGTTSETEDEE 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	10/17 (59%)
		SFP1	<513..603	CDD:227516	52/89 (58%)
		C2H2 Zn finger	519..541	CDD:275368	12/21 (57%)
		zf-H2C2_2	533..560	CDD:463886	16/26 (62%)
		C2H2 Zn finger	549..572	CDD:275368	11/22 (50%)
		C2H2 Zn finger	580..601	CDD:275368	14/20 (70%)
ZIC5	NP_149123.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..171		17/95 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..251		14/74 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..355		6/51 (12%)
		zf_ZIC	366..429	CDD:436441	14/139 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..409		5/106 (5%)
		COG5048	<405..551	CDD:227381	78/147 (53%)
		C2H2 Zn finger	441..461	CDD:275368	11/19 (58%)
		C2H2 Zn finger	469..491	CDD:275368	12/21 (57%)
		C2H2 Zn finger	499..521	CDD:275368	11/22 (50%)
		C2H2 Zn finger	529..551	CDD:275368	15/22 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..568		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..639		5/21 (24%)