DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Zxdc

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_766590.1	Gene:	Zxdc / 80292	MGIID:	1933108	Length:	858	Species:	Mus musculus

Alignment Length:	885	Identity:	184/885 - (20%)
Similarity:	286/885 - (32%)	Gaps:	276/885 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 GLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRL----GSPRPPGGSIRASISRKRALSSSPY 222
            |.|...::..||..||.||::...:....|..:|.:    .:|.|...|:..        :::|
Mouse    97 GASPTEQVPAAAPGAALAGTVTIHNQDLLVRFDRGVFTLAAAPAPAAPSLHP--------ATTP- 152

  Fly   223 SDSFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASA 287
                      ...|:|.|....|...:||.|.:|     ....|...:...:..|::.|||  :.
Mouse   153 ----------GLEPSSAAASRRGPVAASAGSPAY-----RCPEPQCALSFAKKHQLKVHLL--TH 200

  Fly   288 GLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKN 352
            |.|....|.:....|.... ..||..|:.:      ..||.::...........:.....::||.
Mouse   201 GSLQGRRPFKCPLDGCGWA-FTTSYKLKRH------LQSHDKLRPFSCPVGGCGKKFTTVYNLKA 258

  Fly   353 LDDAREKKGPFK-DVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLD 416
            .....|::..|| :|..|:                                  .|...|:||...
Mouse   259 HMKGHEQESLFKCEVCAER----------------------------------FPTHAKLNSHQR 289

  Fly   417 EYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNK 481
            .:..      |...|.|         |.||           |...|||...|..| |..|.: .:
Mouse   290 SHFE------PERPYKC---------DFPG-----------CEKTFITVSALFSH-NRAHFR-EQ 326

  Fly   482 KAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKP 546
            :.|.|.:..|   .|.:.....|.:|:|.||||:|..|..:.|...::.:..|..|.|.|..::.
Mouse   327 ELFSCSFPGC---NKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHKRKHDDDRR 388

  Fly   547 YTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANK 611
            :||...||.|:|:.| :..|..:.||...||:.|...||..|::..|||..|           :|
Mouse   389 FTCPVEGCGKSFTRA-EHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIH-----------SK 441

  Fly   612 KH--------KGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDIS 668
            ||        ...|::..|...   .|:|:::.|.:......:|         ..|.:::.|.::
Mouse   442 KHLQDVGTPKSRCPVSSCNRLF---TSKHSMKAHVVRQHSRRQD---------LVPQLEAPSSLT 494

  Fly   669 SSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTI 733
            .|:.              .|....:|..|:|                 |.|:.:....|:|:||.
Mouse   495 PSSE--------------LSSPGQSELTNID-----------------LAALFSDTPANSSSSTA 528

  Fly   734 GGSVLARQRFRGRLQTKGINS-STIMLCNIPESNRTFGISELNQRITELKMEP--------GTDA 789
            |..    :.....:.|..:.| |:.:..|:|.:|.:.|..:....:....|.|        ||.|
Mouse   529 GSD----EALNSGILTIDVTSVSSSLGGNLPTNNNSLGPMDPLVLVAHGDMPPSLDSPLVLGTSA 589

  Fly   790 EIKIPKLPNTTIGGYTEDPLQ------------------NQTSFRNTVSNK---QGTVSGSIQGQ 833
            .:..|       |.::.|..|                  ||.|...|.||.   .||...|
Mouse   590 TVLQP-------GSFSADDSQAMSTGAVGCLVALPVRNLNQDSPALTPSNNLTAPGTTPTS---- 643

  Fly   834 FRRDSQNSTAS-------------------TYYGSMQSRRSSQSSQVSSIPTMRPNPSCNS---- 875
              .|:...|.|                   ...|..:|...|||  |.|..|.||....:|
Mouse   644 --SDTTQETGSVPDLLVPIKVEQDLSPVPDVVQGQKESHGPSQS--VLSSSTERPGAQKDSELSA 704

  Fly   876 -TASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNK---SLNACINKPNIGVQGVGI 936
             |.|.|  :..|.|.|             |....:.::.|:..|   |.....:..:..|:| |.
Mouse   705 GTGSLY--LESGGSAR-------------TDYRAIQLVKKKKQKGTGSDEGASDSAHRKVKG-GT 753

  Fly   937 YNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRFSVPS 976
            .|     ||..|             |..|:...|...|||
Mouse   754 IN-----PPHVH-------------SGQHSCFCGTLMVPS 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	10/26 (38%)
		C2H2 Zn finger	519..541	CDD:275368	5/21 (24%)
		zf-H2C2_2	533..560	CDD:290200	10/26 (38%)
		C2H2 Zn finger	549..572	CDD:275368	7/22 (32%)
		C2H2 Zn finger	580..601	CDD:275368	8/20 (40%)
Zxdc	NP_766590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..108		2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..175		9/51 (18%)
		C2H2 Zn finger	178..200	CDD:275368	5/23 (22%)
		zf-C2H2_aberr	209..354	CDD:293622	38/216 (18%)
		C2H2 Zn finger	211..233	CDD:275368	4/28 (14%)
		zf-H2C2_2	226..252	CDD:290200	3/31 (10%)
		C2H2 Zn finger	241..263	CDD:275368	2/21 (10%)
		C2H2 Zn finger	271..291	CDD:275368	6/53 (11%)
		C2H2 Zn finger	300..322	CDD:275368	11/42 (26%)
		C2H2 Zn finger	334..353	CDD:275368	5/21 (24%)
		C2H2 Zn finger	361..383	CDD:275368	5/21 (24%)
		zf-H2C2_2	376..402	CDD:290200	10/25 (40%)
		C2H2 Zn finger	391..413	CDD:275368	7/22 (32%)
		COG5048	392..>691	CDD:227381	76/372 (20%)
		C2H2 Zn finger	421..443	CDD:275368	9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..652		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..714		14/46 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..751		4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840