DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and ZXDC

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens

Alignment Length:	555	Identity:	126/555 - (22%)
Similarity:	200/555 - (36%)	Gaps:	151/555 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 PGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVK 470
            |...|::|....:..      |...|.|         |.||           |...|||...|..
Human   278 PTHAKLSSHQRSHFE------PERPYKC---------DFPG-----------CEKTFITVSALFS 316

  Fly   471 HINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLK 535
            | |..|.: .::.|.|.:..|:   |.:.....|.:|:|.||||:|..|..:.|...::.:..|.
Human   317 H-NRAHFR-EQELFSCSFPGCS---KQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLL 376

  Fly   536 THLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSL----R 596
            .|.|.|..::.:||...||.|:|:.| :..|..:.||...||:.|...||..|::..|||    :
Human   377 RHRRKHDDDRRFTCPVEGCGKSFTRA-EHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSK 440

  Fly   597 KHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSI 661
            |||:.| ||      .....|::..|...   .|:|:::.|.:......:|     :|    |.:
Human   441 KHVQDV-GA------PKSRCPVSTCNRLF---TSKHSMKAHMVRQHSRRQD-----LL----PQL 486

  Fly   662 KSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNG 726
            ::.|.::.|:.              .|....:|..|:|                 |.|:.:....
Human   487 EAPSSLTPSSE--------------LSSPGQSELTNMD-----------------LAALFSDTPA 520

  Fly   727 NASASTIGGSVLARQRFRGRLQTKGINS-STIMLCNIPESNRTFGISELNQRITELKMEPGTDAE 790
            |||.|. |||   .:.....:.|..:.| |:.:..|:|.:|.:.|..|....:....:.|..|:.
Human   521 NASGSA-GGS---DEALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPLVLVAHSDIPPSLDSP 581

  Fly   791 IKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQG-----QFRRDSQNSTASTYYGSM 850
            :.:         |.....|| |.||  :|.:.| |||....|     ..:..|.:..|.|
Human   582 LVL---------GTAATVLQ-QGSF--SVDDVQ-TVSAGALGCLVALPMKNLSDDPLALT----- 628

  Fly   851 QSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKE 915
                 |.|:..:.|.|...:.:....||..:.::|......|....||
Human   629 -----SNSNLAAHITTPTSSSTPRENASVPELLAPIKVEPDSPSRPGA----------------- 671

  Fly   916 SNKSLNACINKPNIGVQ--GVGIYNSSLPPPPSSH 948
                         :|.|  ..|:..|:||.|...|
Human   672 -------------VGQQEGSHGLPQSTLPSPAEQH 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	10/26 (38%)
		C2H2 Zn finger	519..541	CDD:275368	5/21 (24%)
		zf-H2C2_2	533..560	CDD:290200	10/26 (38%)
		C2H2 Zn finger	549..572	CDD:275368	7/22 (32%)
		C2H2 Zn finger	580..601	CDD:275368	10/24 (42%)
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174
		C2H2 Zn finger	177..199	CDD:275368
		zf-C2H2_aberr	208..353	CDD:293622	24/105 (23%)
		zf-C2H2	208..232	CDD:278523
		C2H2 Zn finger	210..232	CDD:275368
		C2H2 Zn finger	240..262	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368	3/11 (27%)
		COG5048	<284..443	CDD:227381	53/190 (28%)
		C2H2 Zn finger	299..321	CDD:275368	11/42 (26%)
		C2H2 Zn finger	333..352	CDD:275368	5/21 (24%)
		C2H2 Zn finger	360..382	CDD:275368	5/21 (24%)
		zf-H2C2_2	375..401	CDD:290200	10/25 (40%)
		C2H2 Zn finger	390..412	CDD:275368	7/22 (32%)
		COG5048	391..>584	CDD:227381	56/247 (23%)
		C2H2 Zn finger	420..442	CDD:275368	7/21 (33%)
		Required for transcriptional activation	579..688		31/161 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696		11/64 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756
		Interaction with CIITA	781..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840