DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and ZXDA

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_009087.1	Gene:	ZXDA / 7789	HGNCID:	13198	Length:	799	Species:	Homo sapiens

Alignment Length:	461	Identity:	105/461 - (22%)
Similarity:	169/461 - (36%)	Gaps:	123/461 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 CHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPH 517
            |.:..|:..|||...|..| |..|.: .::.|.|.:..|:   |.:.....|.:|:|.||||:|.
Human   391 CAFSGCKKTFITVSALFSH-NRAHFR-EQELFSCSFPGCS---KQYDKACRLKIHLRSHTGERPF 450

  Fly   518 KCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKA 582
            .|.|:||...::.:..|..|.|.|..::.:.|...||.|:|:.| :..|..:.||...||::|..
Human   451 LCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRA-EHLKGHSITHLGTKPFVCPV 514

  Fly   583 PGCTKRYTDPSSLRKHVKTVHGAEFYANKKH--------KGLPLNDANSRLQQNNSRHNLQEHNI 639
            .||..|::..|||..|           :|||        ...|::..|...   .|:|:::.|.:
Human   515 AGCCARFSARSSLYIH-----------SKKHLQDVDTWKSRCPISSCNKLF---TSKHSMKTHMV 565

  Fly   640 DSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDL--AENLNLDDGW 702
            ......:|. |.::                   ...|.:..|..|.:...:||  ||.::|
Human   566 KRHKVGQDL-LAQL-------------------EAANSLTPSSELTSQRQNDLSDAEIVSL---- 606

  Fly   703 NCDDDVDVADLPIVLRAMVNIG----NGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIP 763
             ..|..|.....::..|:||.|    :..:.:||:.|                         ::|
Human   607 -FSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAG-------------------------HLP 645

  Fly   764 ESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQN-QTS-FRNTVSNKQGTV 826
            .:|        |..:.:....|...|               |.||.|: .|| |..|.:
Human   646 ANN--------NNSVGQAVDPPSLMA---------------TSDPPQSLDTSLFFGTAA------ 681

  Fly   827 SGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPG---CS 888
            :|..|.....|..:|.:....||:.|.....||......|    ||...|.. .|.::|.   |.
Human   682 TGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALT----PSSKLTVD-TDTLTPSSTLCE 741

  Fly   889 RRSSQM 894
            ...|::
Human   742 NSVSEL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	12/26 (46%)
		C2H2 Zn finger	519..541	CDD:275368	7/21 (33%)
		zf-H2C2_2	533..560	CDD:290200	9/26 (35%)
		C2H2 Zn finger	549..572	CDD:275368	7/22 (32%)
		C2H2 Zn finger	580..601	CDD:275368	8/20 (40%)
ZXDA	NP_009087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89
		Required for interaction with ZXDC. /evidence=ECO:0000269\|PubMed:17493635	267..573		56/201 (28%)
		C2H2 Zn finger	269..291	CDD:275368
		zf-C2H2_aberr	300..445	CDD:293622	16/58 (28%)
		zf-C2H2	300..324	CDD:278523
		C2H2 Zn finger	302..324	CDD:275368
		C2H2 Zn finger	332..354	CDD:275368
		zf-H2C2_2	346..369	CDD:290200
		C2H2 Zn finger	362..382	CDD:275368
		C2H2 Zn finger	391..413	CDD:275368	8/22 (36%)
		C2H2 Zn finger	425..444	CDD:275368	5/21 (24%)
		COG5048	<437..568	CDD:227381	43/145 (30%)
		C2H2 Zn finger	452..474	CDD:275368	7/21 (33%)
		zf-H2C2_2	467..493	CDD:290200	9/25 (36%)
		C2H2 Zn finger	482..504	CDD:275368	7/22 (32%)
		C2H2 Zn finger	512..534	CDD:275370	9/32 (28%)
		Required for transcriptional activation	572..699		36/205 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840