DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Zxdb

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001074942.1	Gene:	Zxdb / 668166	MGIID:	3694898	Length:	873	Species:	Mus musculus

Alignment Length:	875	Identity:	181/875 - (20%)
Similarity:	288/875 - (32%)	Gaps:	290/875 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 GLGLGSADFLGSRG---------LSSLG--------ELHNAAVAAAAAGSLASTDFHFSVDGNR- 195
            |.|.|.....||||         |..:|        |...|.|....||:           |.|
Mouse   108 GGGGGGGGGGGSRGGSDDFFLLLLDPVGGDVETVGTEQAGAPVRREEAGA-----------GPRP 161

  Fly   196 -RLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHI 259
             |..|..||.|.....   .|.||:.|.:           ||...|     ..|.:||:.:   .
Mouse   162 ERRQSAGPPAGRPEPG---PRCLSAVPAA-----------SPLPAA-----GPGPAAAAAA---A 204

  Fly   260 SATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTP--------------------------QQV 298
            :|.|......:|:..|      |||...|:|...||                          .|.
Mouse   205 AAAAFAGTITIHNQDL------LLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIAPQA 263

  Fly   299 AASGF----SIGHMPTSASLRVNDVHPNLSDSHI-----QITTSPTVTKDVSQVPAAAFSLKNLD 354
            ||:||    :......:|..::.|. |.|....:     :....|...::.::.||||.:.....
Mouse   264 AAAGFPPAAAAAAAAAAAGAQLGDC-PELPPDLLLAEPAEPAACPAPPEEEAEAPAAAAAQSPRG 327

  Fly   355 DAREKKGPFKDVV----PE-QPSSTSGGVAQVEA-----DSASSQLSDRCYNNVVNNITGIPGDV 409
            .|....||  .||    || |...|.....|::.     .|:..|...:|      .::|.....
Mouse   328 PAGPGPGP--GVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKC------PLSGCGWTF 384

  Fly   410 KVNSRLDEYI--------------NCG---------SISIPSNEYD-------CANADTTDIK-- 442
            ..:.:|..::              .||         ...:..:|.:       |..:..|..|
Mouse   385 TTSYKLKRHLQSHDKLRPFGCPVQGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLS 449

  Fly   443 ---------DEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPF 498
                     :.|     ..|.:..|:..|||...|..| |..|.: .::.|.|.:..|:   |.:
Mouse   450 THQRSHFEPERP-----YQCAFSGCKKTFITVSALFSH-NRAHFR-EQELFACSFPGCS---KQY 504

  Fly   499 KAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASD 563
            .....|.:|:|.||||:|..|.|:||...::.:..|..|.|.|..::.:||...||.|:|:.| :
Mouse   505 DKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHEDDRRFTCPVEGCGKSFTRA-E 568

  Fly   564 RAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKH--------KGLPLND 620
            ..|..:.||...||::|...||..|::..|||..|           :|||        ...|:..
Mouse   569 HLKGHSITHLGTKPFVCPVEGCCARFSARSSLYIH-----------SKKHLQDVGAWKSRCPVPT 622

  Fly   621 ANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL 685
            .|...   .|:|:::.|.......|:|. |.::  .::.|:...|:::|.....::|
Mouse   623 CNKLF---TSKHSMKTHMTKRHNLSQDL-LAQL--EAANSLTPSSELTSPGQSDLSG-------- 673

  Fly   686 TYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNAS---ASTIGGSVLARQRFRGRL 747
                   ||.::|           .:|:|         |:|:|:   .:.:...:|.       :
Mouse   674 -------AELVSL-----------FSDVP---------GHGSAAVLDTALVNSGILT-------I 704

  Fly   748 QTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEP----GTDAEIKIPKLP---------NT 799
            ....:|||  :..::|..|.:      |........||    |..::     ||         .|
Mouse   705 DVASVNSS--LAGSLPADNNS------NNHSLGQAAEPRALRGAPSD-----LPQSLDTSLFFGT 756

  Fly   800 TIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSI 864
            ::.||...||.            ...||....|.|             ||:..:.||...|
Mouse   757 SVAGYQHSPLD------------MDDVSAGNVGLF-------------GSLALKNSSLEPQ---- 792

  Fly   865 PTMRPNPSCNSTASFYDPISPGCSRRSSQM 894
             .:.|:...........|.|..|....|::
Mouse   793 -ALTPSNKLTVDTEALTPSSTLCENSVSEL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	12/26 (46%)
		C2H2 Zn finger	519..541	CDD:275368	7/21 (33%)
		zf-H2C2_2	533..560	CDD:290200	10/26 (38%)
		C2H2 Zn finger	549..572	CDD:275368	7/22 (32%)
		C2H2 Zn finger	580..601	CDD:275368	8/20 (40%)
Zxdb	NP_001074942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..120		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..184		15/59 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..330		5/28 (18%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	340..646		75/336 (22%)
		C2H2 Zn finger	342..364	CDD:275368	5/21 (24%)
		zf-C2H2_aberr	373..518	CDD:293622	26/160 (16%)
		C2H2 Zn finger	375..397	CDD:275368	3/27 (11%)
		C2H2 Zn finger	405..427	CDD:275368	2/21 (10%)
		zf-H2C2_2	419..442	CDD:290200	2/22 (9%)
		C2H2 Zn finger	435..455	CDD:275368	3/19 (16%)
		C2H2 Zn finger	464..486	CDD:275368	8/22 (36%)
		C2H2 Zn finger	498..517	CDD:275368	5/21 (24%)
		COG5048	<510..642	CDD:227381	44/146 (30%)
		C2H2 Zn finger	525..547	CDD:275368	7/21 (33%)
		C2H2 Zn finger	555..577	CDD:275368	7/22 (32%)
		C2H2 Zn finger	585..607	CDD:275370	9/32 (28%)
		Required for transcriptional activation. /evidence=ECO:0000250	645..776		33/200 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840