DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and glis3

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_017213470.1	Gene:	glis3 / 571000	ZFINID:	ZDB-GENE-070112-2232	Length:	804	Species:	Danio rerio

Alignment Length:	866	Identity:	247/866 - (28%)
Similarity:	339/866 - (39%)	Gaps:	243/866 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYR 114
            ||:..|.|:.|   .|.|: |....|.|.:|||                       ...|:.|.|
Zfish   107 SSAFLVQSLSP---ASASV-THSSSQTCPQNTL-----------------------TLPFNDASR 144

  Fly   115 IPGYMEQL----YSLQRTNS--ASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGE--LHN 171
            .....|.|    .||..|.|  :|....||            |......||.:..:.|.|  :..
Zfish   145 CLLSRESLASTTLSLAETQSVRSSKLDWPY------------GYRVLPPLGHQTANQLSESTVPE 197

  Fly   172 AAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD--SFDINSMIRF 234
            ::::.:.:...:...:.|..||:    |||      .::.|:|||||.||.||  ..|:||:||.
Zfish   198 SSLSESVSNPASLPHYLFKEDGS----SPR------LSARSKKRALSLSPLSDGLGLDLNSIIRT 252

  Fly   235 SPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQ-QIQAHLLRASAGLLNPMTPQQV 298
            ||.||...:.|||                ::|.||...:.|| .:..|||    |:.....|
Zfish   253 SPTSLVAYIIGSR----------------ISPASHNTPSPLQADVCGHLL----GIRGSGIP--- 294

  Fly   299 AASGFSIGHMPTSASLRVNDVHPNLSDSHI--QITTSPTVTKDVSQVPAAAFSLKNLDDAREKKG 361
            .:|..||.   .|.|||:..:....::..:  ||...|...| .||.....|.:     :|..:.
Zfish   295 TSSKHSIS---VSESLRMQPLEDQFTNLLVEQQILPDPQTAK-ASQTHTLQFEV-----SRIVRS 350

  Fly   362 PFKDVVPEQPSST------SGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYIN 420
            |.....|..|.|.      ...|.|::..:....:                    :....:|..:
Zfish   351 PSPPRGPPPPYSAHHQQQQQPRVLQLQRPAGLQPM--------------------LEEEEEEEES 395

  Fly   421 CGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNK-KAF 484
            ||..       .|                   |.|..|...:..:|.|||||...|:...| :.|
Zfish   396 CGGT-------HC-------------------CCWLHCGAIYSHRDALVKHIEKIHVDQRKGEDF 434

  Fly   485 VCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTC 549
            .|.|..|.|..|||.|:|.|::|||.|:||||:||:||||.||:|||||||.|||||||||||.|
Zfish   435 TCFWAGCARKHKPFNARYKLLIHMRVHSGEKPNKCSFEGCQKAFSRLENLKIHLRSHTGEKPYVC 499

  Fly   550 EYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHK 614
            .:|||.|||||:||||||| |||.:.|||.|:..||.||||||||||||||:           |.
Zfish   500 PHPGCLKAFSNSSDRAKHQ-RTHVDTKPYACQIQGCGKRYTDPSSLRKHVKS-----------HS 552

  Fly   615 GLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSES--DISSSNHHLVNG 677
                      |::..:|..|:.    ||..|:|. |.:.| |..|...|.|  |:..|.||
Zfish   553 ----------LKEQQARKKLRR----SSDLSQDG-LSECL-TVQPLQHSLSTLDLIESKHH---- 597

  Fly   678 VRASDSLLTYSP-DDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLARQ 741
                      || |||.....|:.                 .:..|..|   |...|.|.....|
Zfish   598 ----------SPTDDLYTVFTLNQ-----------------PSQTNTLN---SPMQIAGGPQTHQ 632

  Fly   742 RFRGRLQTKGINSSTIML---CNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTTIGG 803
            ......|...|:.:...|   .:.....:|..|.:::|          |....:|.::..|.:..
Zfish   633 SPHQTHQAHQIHQTQTHLTHQTHQAHQTQTHHIQQIHQ----------THLTHQIQQIHQTHLSP 687

  Fly   804 Y-TEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTY-YGSMQSRRSSQS-------- 858
            : ...|||....|.:..|:|    :.....|.|..:|:..::.: |.......||.|
Zfish   688 HGALPPLQGNNRFLSPNSHK----APGFCSQPRTSAQDGFSAVFSYADSDKHISSCSVMQTPMFE 748

  Fly   859 SQVSSIPTMRPNPS----CNS 875
            ..:||.|.:..|.|    |.|
Zfish   749 DNLSSSPQIHSNISAVLDCQS 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	17/26 (65%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	16/20 (80%)
glis3	XP_017213470.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040