DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and lmd

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_732811.1	Gene:	lmd / 42717	FlyBaseID:	FBgn0039039	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	188/697 - (26%)
Similarity:	279/697 - (40%)	Gaps:	199/697 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 RPPGGSIRASI-----------SRKRALSSSPYSDSFDINSMIRFSPNSLATIMNGSRGSSAASG 254
            :|...||...|           |:.::..|||:.|::     :.|:...:    :.:..|||||.
  Fly   189 QPANDSINLDIDYFNYDEINCQSKNQSPCSSPHLDAW-----LNFNLGEI----SAAASSSAASP 244

  Fly   255 SYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPM--TPQQV---------------AASG 302
            ..|::..              :|::.....|....:|..  ||:.:               ..||
  Fly   245 KLGNVFE--------------EQVKEEASPAKLPSMNSTFGTPKCIPMCASNYEDYANLYQQGSG 295

  Fly   303 FSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVV 367
            :|           ..:.|.|::    |:...|      ::...|.:::..||:.         ::
  Fly   296 YS-----------TENYHNNMA----QVVEKP------NREHKAIWTIDELDEL---------ML 330

  Fly   368 PEQPSSTSGGVAQVEADSASSQL---------SDRCYNNVVNNIT------------GIPGDVKV 411
            .||.......:.|........||         :..|.:::||.::            ....|...
  Fly   331 GEQQQFLQHHLQQQHLQEQQEQLHQPHGQEQQTQNCKDDLVNYLSDEFIKAEEFRSLDSDDDENY 395

  Fly   412 NSRLDEYINCGSISIPSNEYDCANADTT--DIKDEP-GDFIETNCHWRSCRIEFITQDELVKHIN 473
            |...|:..|  .:..|..|.| ...|:|  |.:.|| .:.|...|.|..|..||..|...|:||.
  Fly   396 NEEEDDLDN--DVFAPPAESD-PKPDSTCCDPEAEPENEVIPLICRWTGCDEEFPHQQAFVEHIE 457

  Fly   474 NDHIQTNK-KAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTH 537
            ..|:...| :.|.|.|.||.|..|||.|:|.|::|||.|:||||:||.|.||.||:|||||||.|
  Fly   458 KCHVDVRKGEDFSCFWLDCPRRYKPFNARYKLLIHMRVHSGEKPNKCPFPGCNKAFSRLENLKIH 522

  Fly   538 LRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTV 602
            .||||||:||.|:|.||.|||||:||||||| |||.:.|||.|:.||||||||||||||||||.
  Fly   523 QRSHTGERPYGCQYKGCLKAFSNSSDRAKHQ-RTHYDTKPYACQLPGCTKRYTDPSSLRKHVKN- 585

  Fly   603 HGAEFYANKKHKGLPLNDANSRLQQNNS-----------------RHNLQEHNIDSSPCSEDSHL 650
            |.             |.:||.:|::.::                 ||        |........:
  Fly   586 HA-------------LRNANGQLRRKSAGGASVPPSGPKKAAKTRRH--------SESALVQRGV 629

  Fly   651 GKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL----------------TYSPDDLAENLNLD 699
            |..:|.:.||...:.....||       ..|::||                .:.|    ||....
  Fly   630 GAGVGVAVPSAPGDQRQHRSN-------SCSEALLLQQHQQQQQQQQQQQKQHQP----ENERTT 683

  Fly   700 DGWNCDDDV----------DVADLPIVLRAMVNIG-NGNASASTIGGSVLARQRFRGRLQTKGIN 753
            |..||...|          ::::..:::....:.| .|.|:.:|...:..|...:..........
  Fly   684 DRSNCGTGVAANNNSMNFNELSNCIVIIEHNQSGGPAGPATLATATATTTATATYGNGNMAPAPE 748

  Fly   754 SSTIMLC------NIPESNRTFG-----ISELNQRITELKMEPGTDA 789
            :..:.:|      |...:|..:.     :|||.|.:|..| ..||.|
  Fly   749 TEVLSVCSGGGSSNSNSNNNRYNANINQLSELEQLLTTAK-PTGTPA 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	16/26 (62%)
		C2H2 Zn finger	519..541	CDD:275368	15/21 (71%)
		zf-H2C2_2	533..560	CDD:290200	19/26 (73%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	18/20 (90%)
lmd	NP_732811.1	zf-H2C2_2	489..515	CDD:290200	16/25 (64%)
		C2H2 Zn finger	504..526	CDD:275368	15/21 (71%)
		C2H2 Zn finger	534..556	CDD:275368	17/22 (77%)
		C2H2 Zn finger	564..586	CDD:275368	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466594
Domainoid	1	1.000	48	1.000	Domainoid score	I8021
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56141at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.880