Protein Alignment ci and gli3

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_991291.1
• Gene: gli3 / 403042
• ZFINID: ZDB-GENE-041111-162
• Length: 1553
• Species: Danio rerio
• Alignment Length: 1591
• Identity: 452/1591 - (28%)
• Similarity: 657/1591 - (41%)
• Gaps: 407/1591 - (25%)

  Fly    44 HHPTDVSSSVT------VPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINV 102
            |||..:....|      .||.:|:.....::..|  |.. ::.:|:..:.|::...
Zfish   133 HHPVPIDDRHTQGRYIYEPSPVPSLHMPPALAAS--PTF-SDISLIRISPHRNPSM--------- 185

  Fly   103 TGQPHDFHPAY-RIPGYMEQLYSLQRTNSAS-----------SFHDPYVNCASAFHLAGLGLGS- 154
             |....|:|:: .|..||:.:.||..:.|.|           ..|...:..|..:|...|.:|.
Zfish   186 -GTDSPFNPSHPYINPYMDYIRSLHSSPSLSMVSAARGLSPADTHHTGLTTAEYYHQMALLVGHR 249

  Fly   155 ---ADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRA 216
               ||.:.|.| |:.|.              ||:..|  ::..:.:.|.|.|...:....||||.
Zfish   250 SPYADLIPSVG-STTGP--------------ASSALH--MEYLQAMESSRFPSPRLINRPSRKRP 297

  Fly   217 LSSSP-YSD-SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTRLQQI 278
            :.:|| .|| |||:.:|||.|||||.||:|.||.||:.||||||:||..::| :|..:......:
Zfish   298 IPNSPSLSDPSFDLQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPVAL 362

  Fly   279 QAH--LLRASAGLLNPMTPQQVAASGFSIGHMP----TSASLRVNDVHPNLSDSHIQITTSPTVT 337
            |.|  |:....|::           |.:.||.|    ::.:.......|.:..|.:..|....|:
Zfish   363 QMHQQLISRQPGIV-----------GSAFGHSPPLMHSALAFSTQRPVPAIQTSSLAPTERSIVS 416

  Fly   338 KDVSQVPAAAFSLKNL-DDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNN 401
            .|....|.:..::.:. |....|:...|   ||:...:...|:..|.               :|.
Zfish   417 NDSQSKPTSESAVSSTGDPMNHKRSKLK---PEEEPPSPRAVSMQEQ---------------MNG 463

  Fly   402 ITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQD 466
            :|.:..:                           .|..:.|.||....||||||..|..||.||:
Zfish   464 MTLVKEE---------------------------GDKEEGKQEPEVVYETNCHWDGCCREFDTQE 501

  Fly   467 ELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRL 531
            :||.|||||||...||.||||||:|:|.:|||||||||||||||||||||||||||||.||||||
Zfish   502 QLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRL 566

  Fly   532 ENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLR 596
            ||||||||||||||||.||:.||:|||||||||||||||||||||||:||.||||||||||||||
Zfish   567 ENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLR 631

  Fly   597 KHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGK------MLG 655
            ||||||||.|.:..||.:|........:.::..:..:.:|:...:|...|...:..      |..
Zfish   632 KHVKTVHGPEAHVTKKQRGETYPRPPPQPREPGATTDQKEYTHATSKQDECLQVKSIKTEKPMTS 696

  Fly   656 TSSPSIKS--ESDISSSNHHLVNGVRASDSLLTYSPDDLA-ENLNLDDGWNCDDDV-----DVAD 712
            .|||..:|  .||.|.:..|:..||:     ||.:...|| |...|:|..|.::|.     :..|
Zfish   697 QSSPGSQSSCSSDQSINGPHVSQGVQ-----LTVNSIGLAGEVAMLEDMENEEEDEENREGEKED 756

  Fly   713 LPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIP----ESNRTFGISE 773
            .||:   ...:....:||:||   ||...|..||                |    |..:...:.:
Zfish   757 APIM---DSTVSTATSSAATI---VLQTHRSVGR----------------PLRWMEHVKMERLRQ 799

  Fly   774 LNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFR----NTVSNKQGTVSGSIQGQF 834
            :|..:..|...|.|... |...:|..|..|..   |...||.|    ...||.:.|:...:..
Zfish   800 VNGAVPRLGFLPPTPPR-KGQAMPALTGKGQC---LGRMTSVRVPPCPEPSNTELTILSLLHE-- 858

  Fly   835 RRDSQNSTASTYYGSMQSRR--------SSQSSQVSSIPTMRPNPSCN--STASFYDPISPGCSR 889
            ||||..|..|:.|.| .|||        ||:.|..:|:....|:...:  |....|||||...||
Zfish   859 RRDSSGSNTSSAYLS-SSRRSSGISPCFSSRCSSQASLSEYSPHRHIHNLSATDSYDPISTDASR 922

  Fly   890 RSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACIN---------KPNIGVQGVGIYNSSLPPP- 944
            |||:.|.....:|.....|...:.|.|.......:|         |........|      |||
Zfish   923 RSSEASQYDGGSSSAVVFGGSGVFKGSGMGSRGDLNLTPAQHYSLKAKYAAATGG------PPPT 981

  Fly   945 --PS-SHLIATNLK-----RLQRKDSEYHNFTSGRFSVPSYM---------HSLHIKNNKPVGEN 992
              || .|:   |||     :..|||       :|:.::|..:         |:.|  :::.|.:.
Zfish   982 PLPSMGHI---NLKTHFALKEDRKD-------TGQLTLPPLVRSRRCSDGAHNSH--DSQAVYQR 1034

  Fly   993 E---FDKAIASNARRQTDPV---PNINLDPLTNISRFST--------TPHSFDINVGKTNNIASS 1043
            :   |......|.||.:||.   .|::...|..:..||:        .|.|:    |.:|....|
Zfish  1035 KGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQVRHFSSLNNMTSSPNPASY----GYSNREDHS 1095

  Fly  1044 INKDN--LRKDLFTVSIKA-------------DMAMTSD---QHPNERINLD--------EVEEL 1082
            :|..|  ...|.|...:.:             ::.|..|   ...||.|..|        :.|.:
Zfish  1096 LNLQNSTCHVDSFQSGLHSPCPPSIMEQSALENIFMNQDGLLLRVNENIQSDFMQYLHSQDQESI 1160

  Fly  1083 ILPDEMLQYLNLVKDDTNHLEKEHQ------------AVPVGSN-VSETIAS-----------NH 1123
            |:.|......| ..||.|.|..:.|            .:|:.|| ||...|.           ..
Zfish  1161 IIQDNHRPIFN-PADDQNFLSPQQQQEGVEQEDTRIDLMPIQSNEVSSASADVTIPRQPFQRCGR 1224

  Fly  1124 YREQSNIYYTNKQILTPPSNVDIQPNTTKFTVQDKFAMTAVGG-SF----SQRELSTLAVPNEHG 1183
            :.:||.   :.........|:.:|.....| :....|:..:|| |:    |::.|.......|..
Zfish  1225 WSDQSG---SVSNAFGRFGNMVVQQQPIDF-IDQHSALQHMGGISYGCRNSEQHLQVAKPAQEKS 1285

  Fly  1184 HAK-------CESFHHQSQKYMNTDIGSKQQSALPSA--HQRQTEKS-------NYNQIIDSSMT 1232
            ..|       ..:|..:|:   :::.|....|.:.||  ||:.::.:       ..|||.:...:
Zfish  1286 RMKTGIKTESSSTFQLESK---HSNFGRPDFSHIFSAPIHQKCSQHTVVSQSYPQQNQITNQDSS 1347

  Fly  1233 SL---------------PELNVDSIYPRNETENIFKVHGDHDNEI------QCGIISQSQMSPST 1276
            :|               |:..|::.|...:..|...|...|...:      .|.:.:|..:....
Zfish  1348 NLFLQRPGNCSLLLAYRPQPAVNTSYSTRQDINSHNVQSCHPQSLNNRLGTSCSLSNQVSVVKLD 1412

  Fly  1277 NLNN--DGQFSTVNMQ-PITTSKLFPPEPQKIVCDTQASNTSVMHLDTYQRTLEYVQSC--QNWM 1336
            .:|:  ....||:..| |:...|.|.||..|:                   :...||||  ::.|
Zfish  1413 QVNHLQINSCSTIQQQKPVFIDKCFDPEESKL-------------------SHAIVQSCLMESLM 1458

  Fly  1337 -ETNNTS-----------TNQIQSLP------------------GMPVNNTLFPDVSSSTHPYH- 1370
             |...||           |::::..|                  |..|:::...: |..:..:|
Zfish  1459 AEKERTSKVLLSSGVGQVTSKVERSPAEKVGLGICSIGGDSYDQGSVVSSSRLSN-SHDSFAFHS 1522

  Fly  1371 ---GT-NMVINDMTTSLTSLLEENRYLQMMQ 1397
               || ||.|:||.:.||:|.||:::|.::|
Zfish  1523 VDPGTNNMAISDMNSLLTTLAEESKFLAIIQ 1553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	17/17 (100%)
		SFP1	<513..603	CDD:227516	82/89 (92%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:463886	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
gli3	NP_991291.1	FOXP-CC	488..>522	CDD:465036	21/33 (64%)
		C2H2 Zn finger	524..546	CDD:275368	17/21 (81%)
		SFP1	<548..638	CDD:227516	82/89 (92%)
		C2H2 Zn finger	554..576	CDD:275368	20/21 (95%)
		C2H2 Zn finger	584..607	CDD:275368	19/22 (86%)
		C2H2 Zn finger	615..636	CDD:275368	19/20 (95%)