DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ci and gli3

DIOPT Version :9

Sequence 1:NP_524617.3 Gene:ci / 43767 FlyBaseID:FBgn0004859 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_991291.1 Gene:gli3 / 403042 ZFINID:ZDB-GENE-041111-162 Length:1553 Species:Danio rerio


Alignment Length:1591 Identity:452/1591 - (28%)
Similarity:657/1591 - (41%) Gaps:407/1591 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HHPTDVSSSVT------VPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINV 102
            |||..:....|      .||.:|:.....::..|  |.. ::.:|:..:.|::...         
Zfish   133 HHPVPIDDRHTQGRYIYEPSPVPSLHMPPALAAS--PTF-SDISLIRISPHRNPSM--------- 185

  Fly   103 TGQPHDFHPAY-RIPGYMEQLYSLQRTNSAS-----------SFHDPYVNCASAFHLAGLGLGS- 154
             |....|:|:: .|..||:.:.||..:.|.|           ..|...:..|..:|...|.:|. 
Zfish   186 -GTDSPFNPSHPYINPYMDYIRSLHSSPSLSMVSAARGLSPADTHHTGLTTAEYYHQMALLVGHR 249

  Fly   155 ---ADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRA 216
               ||.:.|.| |:.|.              ||:..|  ::..:.:.|.|.|...:....||||.
Zfish   250 SPYADLIPSVG-STTGP--------------ASSALH--MEYLQAMESSRFPSPRLINRPSRKRP 297

  Fly   217 LSSSP-YSD-SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTRLQQI 278
            :.:|| .|| |||:.:|||.|||||.||:|.||.||:.||||||:||..::| :|..:......:
Zfish   298 IPNSPSLSDPSFDLQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPVAL 362

  Fly   279 QAH--LLRASAGLLNPMTPQQVAASGFSIGHMP----TSASLRVNDVHPNLSDSHIQITTSPTVT 337
            |.|  |:....|::           |.:.||.|    ::.:.......|.:..|.:..|....|:
Zfish   363 QMHQQLISRQPGIV-----------GSAFGHSPPLMHSALAFSTQRPVPAIQTSSLAPTERSIVS 416

  Fly   338 KDVSQVPAAAFSLKNL-DDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNN 401
            .|....|.:..::.:. |....|:...|   ||:...:...|:..|.               :|.
Zfish   417 NDSQSKPTSESAVSSTGDPMNHKRSKLK---PEEEPPSPRAVSMQEQ---------------MNG 463

  Fly   402 ITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQD 466
            :|.:..:                           .|..:.|.||....||||||..|..||.||:
Zfish   464 MTLVKEE---------------------------GDKEEGKQEPEVVYETNCHWDGCCREFDTQE 501

  Fly   467 ELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRL 531
            :||.|||||||...||.||||||:|:|.:|||||||||||||||||||||||||||||.||||||
Zfish   502 QLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRL 566

  Fly   532 ENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLR 596
            ||||||||||||||||.||:.||:|||||||||||||||||||||||:||.||||||||||||||
Zfish   567 ENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLR 631

  Fly   597 KHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGK------MLG 655
            ||||||||.|.:..||.:|........:.::..:..:.:|:...:|...|...:..      |..
Zfish   632 KHVKTVHGPEAHVTKKQRGETYPRPPPQPREPGATTDQKEYTHATSKQDECLQVKSIKTEKPMTS 696

  Fly   656 TSSPSIKS--ESDISSSNHHLVNGVRASDSLLTYSPDDLA-ENLNLDDGWNCDDDV-----DVAD 712
            .|||..:|  .||.|.:..|:..||:     ||.:...|| |...|:|..|.::|.     :..|
Zfish   697 QSSPGSQSSCSSDQSINGPHVSQGVQ-----LTVNSIGLAGEVAMLEDMENEEEDEENREGEKED 756

  Fly   713 LPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIP----ESNRTFGISE 773
            .||:   ...:....:||:||   ||...|..||                |    |..:...:.:
Zfish   757 APIM---DSTVSTATSSAATI---VLQTHRSVGR----------------PLRWMEHVKMERLRQ 799

  Fly   774 LNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFR----NTVSNKQGTVSGSIQGQF 834
            :|..:..|...|.|... |...:|..|..|..   |...||.|    ...||.:.|:...:..  
Zfish   800 VNGAVPRLGFLPPTPPR-KGQAMPALTGKGQC---LGRMTSVRVPPCPEPSNTELTILSLLHE-- 858

  Fly   835 RRDSQNSTASTYYGSMQSRR--------SSQSSQVSSIPTMRPNPSCN--STASFYDPISPGCSR 889
            ||||..|..|:.|.| .|||        ||:.|..:|:....|:...:  |....|||||...||
Zfish   859 RRDSSGSNTSSAYLS-SSRRSSGISPCFSSRCSSQASLSEYSPHRHIHNLSATDSYDPISTDASR 922

  Fly   890 RSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACIN---------KPNIGVQGVGIYNSSLPPP- 944
            |||:.|.....:|.....|...:.|.|.......:|         |........|      ||| 
Zfish   923 RSSEASQYDGGSSSAVVFGGSGVFKGSGMGSRGDLNLTPAQHYSLKAKYAAATGG------PPPT 981

  Fly   945 --PS-SHLIATNLK-----RLQRKDSEYHNFTSGRFSVPSYM---------HSLHIKNNKPVGEN 992
              || .|:   |||     :..|||       :|:.::|..:         |:.|  :::.|.:.
Zfish   982 PLPSMGHI---NLKTHFALKEDRKD-------TGQLTLPPLVRSRRCSDGAHNSH--DSQAVYQR 1034

  Fly   993 E---FDKAIASNARRQTDPV---PNINLDPLTNISRFST--------TPHSFDINVGKTNNIASS 1043
            :   |......|.||.:||.   .|::...|..:..||:        .|.|:    |.:|....|
Zfish  1035 KGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQVRHFSSLNNMTSSPNPASY----GYSNREDHS 1095

  Fly  1044 INKDN--LRKDLFTVSIKA-------------DMAMTSD---QHPNERINLD--------EVEEL 1082
            :|..|  ...|.|...:.:             ::.|..|   ...||.|..|        :.|.:
Zfish  1096 LNLQNSTCHVDSFQSGLHSPCPPSIMEQSALENIFMNQDGLLLRVNENIQSDFMQYLHSQDQESI 1160

  Fly  1083 ILPDEMLQYLNLVKDDTNHLEKEHQ------------AVPVGSN-VSETIAS-----------NH 1123
            |:.|......| ..||.|.|..:.|            .:|:.|| ||...|.           ..
Zfish  1161 IIQDNHRPIFN-PADDQNFLSPQQQQEGVEQEDTRIDLMPIQSNEVSSASADVTIPRQPFQRCGR 1224

  Fly  1124 YREQSNIYYTNKQILTPPSNVDIQPNTTKFTVQDKFAMTAVGG-SF----SQRELSTLAVPNEHG 1183
            :.:||.   :.........|:.:|.....| :....|:..:|| |:    |::.|.......|..
Zfish  1225 WSDQSG---SVSNAFGRFGNMVVQQQPIDF-IDQHSALQHMGGISYGCRNSEQHLQVAKPAQEKS 1285

  Fly  1184 HAK-------CESFHHQSQKYMNTDIGSKQQSALPSA--HQRQTEKS-------NYNQIIDSSMT 1232
            ..|       ..:|..:|:   :::.|....|.:.||  ||:.::.:       ..|||.:...:
Zfish  1286 RMKTGIKTESSSTFQLESK---HSNFGRPDFSHIFSAPIHQKCSQHTVVSQSYPQQNQITNQDSS 1347

  Fly  1233 SL---------------PELNVDSIYPRNETENIFKVHGDHDNEI------QCGIISQSQMSPST 1276
            :|               |:..|::.|...:..|...|...|...:      .|.:.:|..:....
Zfish  1348 NLFLQRPGNCSLLLAYRPQPAVNTSYSTRQDINSHNVQSCHPQSLNNRLGTSCSLSNQVSVVKLD 1412

  Fly  1277 NLNN--DGQFSTVNMQ-PITTSKLFPPEPQKIVCDTQASNTSVMHLDTYQRTLEYVQSC--QNWM 1336
            .:|:  ....||:..| |:...|.|.||..|:                   :...||||  ::.|
Zfish  1413 QVNHLQINSCSTIQQQKPVFIDKCFDPEESKL-------------------SHAIVQSCLMESLM 1458

  Fly  1337 -ETNNTS-----------TNQIQSLP------------------GMPVNNTLFPDVSSSTHPYH- 1370
             |...||           |::::..|                  |..|:::...: |..:..:| 
Zfish  1459 AEKERTSKVLLSSGVGQVTSKVERSPAEKVGLGICSIGGDSYDQGSVVSSSRLSN-SHDSFAFHS 1522

  Fly  1371 ---GT-NMVINDMTTSLTSLLEENRYLQMMQ 1397
               || ||.|:||.:.||:|.||:::|.::|
Zfish  1523 VDPGTNNMAISDMNSLLTTLAEESKFLAIIQ 1553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ciNP_524617.3 zf-H2C2_2 503..530 CDD:290200 25/26 (96%)
C2H2 Zn finger 519..541 CDD:275368 20/21 (95%)
zf-H2C2_2 533..560 CDD:290200 22/26 (85%)
C2H2 Zn finger 549..572 CDD:275368 19/22 (86%)
C2H2 Zn finger 580..601 CDD:275368 19/20 (95%)
gli3NP_991291.1 C2H2 Zn finger 524..546 CDD:275368 17/21 (81%)
zf-H2C2_2 538..565 CDD:290200 25/26 (96%)
C2H2 Zn finger 554..576 CDD:275368 20/21 (95%)
zf-H2C2_2 568..595 CDD:290200 22/26 (85%)
C2H2 Zn finger 584..607 CDD:275368 19/22 (86%)
C2H2 Zn finger 615..636 CDD:275368 19/20 (95%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593122
Domainoid 1 1.000 112 1.000 Domainoid score I6130
eggNOG 1 0.900 - - E33208_3BFAM
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 431 1.000 Inparanoid score I1687
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003548
OrthoInspector 1 1.000 - - otm24322
orthoMCL 1 0.900 - - OOG6_104319
Panther 1 1.100 - - O PTHR45718
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R588
SonicParanoid 1 1.000 - - X2040
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.820

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