Protein Alignment ci and zic5

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_991290.1
• Gene: zic5 / 403041
• ZFINID: ZDB-GENE-040622-1
• Length: 497
• Species: Danio rerio
• Alignment Length: 525
• Identity: 156/525 - (29%)
• Similarity: 220/525 - (41%)
• Gaps: 123/525 - (23%)

  Fly   229 NSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPM 293
            ||.||.: :..:|.....:..:...|..||      :|.||         .|||.....|
Zfish     9 NSAIRLA-DLASTQALPHQNMTGFPGIGGH------HPHSH---------HAHLHPGEMG----- 52

  Fly   294 TPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAA----------AF 348
            ....||.:.|...||..:.:|:::...|..|....|...|.|.::.....|.|          .|
Zfish    53 NDPGVALTPFGPEHMAQTNALKLSPSQPVQSHPEAQTAASFTSSQTTVGFPVAHPHTGYTTSRDF 117

  Fly   349 SLKNLDDAREKKGPFKDVVPEQPSSTSG--------------GVAQVEADSASSQLSDRC----- 394
            .|:     ||........:.:|.||.|.              |.|:..|....|.|.::.
Zfish   118 ILR-----RELSASAMHALGDQHSSASSPHHHGMFISPTGAYGHAEGGAHPLFSGLHEQAAPGAH 177

  Fly   395 -YNNVVNN--ITGIPGDV-----KVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEP----GD 447
             :::.:|.  ..|:|||:     ....|.:.|   ||.|:.|  |:..|.: .::...|    |.
Zfish   178 HHHHALNGQMRLGLPGDIYGRPEHFGHRPEHY---GSSSLHS--YNSMNLN-VNLATAPHGATGA 236

  Fly   448 FI---------ETNCHW--------RSCRIEFITQDELVKHINNDHI-QTNKKAFVCRWEDCTRG 494
            |:         |..|.|        :.|...|.|..|||.|:..:|: ...:...||.||:|.|.
Zfish   237 FLRYMRQPIKQELICKWIDQEQTAKKPCSKTFSTMHELVNHVTVEHVGGPEQSTHVCFWEECPRE 301

  Fly   495 EKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFS 559
            .|.|||:|.|:.|:|.||||||..|.|.||.|.::|.||||.|.|:||||||:.||:.||.:.|:
Zfish   302 GKAFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFA 366

  Fly   560 NASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVH-----------GAEFYANKKH 613
            |:|||.|| :..|:::|||.||..||.|.||.|||||||:| ||           |:.::.:
Zfish   367 NSSDRKKH-SHVHTSDKPYFCKVRGCDKSYTHPSSLRKHMK-VHCKSPPPPSANTGSSYHPS--- 426

  Fly   614 KGLPLNDANSRLQQNNSRHNLQEHNIDSSP----------CSEDSHLGKMLGTSSPSIKSESDIS 668
             ...:.||   |..|...|..:..|:  ||          |...:....:...||....||||..
Zfish   427 -STTIGDA---LSPNLDPHRNRSSNL--SPQVTNLNEWYVCQGSAGPNNLHTPSSDVPTSESDDE 485

  Fly   669 SSNHH 673
            .|..|
Zfish   486 DSFRH 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	10/17 (59%)
		SFP1	<513..603	CDD:227516	52/89 (58%)
		C2H2 Zn finger	519..541	CDD:275368	12/21 (57%)
		zf-H2C2_2	533..560	CDD:463886	16/26 (62%)
		C2H2 Zn finger	549..572	CDD:275368	11/22 (50%)
		C2H2 Zn finger	580..601	CDD:275368	14/20 (70%)
zic5	NP_991290.1	zf_ZIC	243..286	CDD:436441	11/42 (26%)
		COG5048	297..>489	CDD:227381	83/202 (41%)
		C2H2 Zn finger	298..318	CDD:275368	10/19 (53%)
		C2H2 Zn finger	326..348	CDD:275368	12/21 (57%)
		C2H2 Zn finger	356..378	CDD:275368	11/22 (50%)
		C2H2 Zn finger	386..408	CDD:275368	15/22 (68%)