Protein Alignment ci and gli1

DIOPT Version :9

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_840081.2
• Gene: gli1 / 352930
• ZFINID: ZDB-GENE-030321-1
• Length: 1404
• Species: Danio rerio
• Alignment Length: 1633
• Identity: 426/1633 - (26%)
• Similarity: 594/1633 - (36%)
• Gaps: 576/1633 - (35%)

  Fly   105 QPHDFHPAYRIPGYMEQLYSLQRTNS------ASSFHDPYVNCASAFHLAGLGLGSADFLGSRGL 163
            |||            :.||....|::      |.|...||.:.||:..:|   |.....:.||
Zfish     6 QPH------------QGLYHYDNTSNQPSRGLAPSVRSPYSSEASSVCVA---LSGGQSVNSR-- 53

  Fly   164 SSLGELHNAAVAAAAAGSLASTDFH----FSVDGNRRLGSPRPPGGS------------------ 206
                |::|.::|..|.........|    .|:.|:|  |.|.|.|.|
Zfish    54 ----EMYNPSMAPGACMEPYMRPPHAPPPHSMMGHR--GMPPPEGMSGAPYCNQNMMTSHHNLPH 112

  Fly   207 ------IRAS--------------ISRKRALSSSPYSD-SFDINSMIRFSPNSLATIMNGSRGSS 250
                  :.||              :|:|||||.||.|| |.|:.::||.|||||...:|...|.:
Zfish   113 NQHTSELMASGDASCFSTPRSMLKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVNSRCGPN 177

  Fly   251 AASGSYGHISATALNP----MSHVHSTRLQ-QIQAHLLRASAGL---LNPMTPQQVAASGFSIGH 307
            ..| ||||:|...::|    .|.::.:|.| .|.:|.:.:..|.   |.|..|:.         |
Zfish   178 NPS-SYGHLSVGTMSPSLGFSSSINYSRPQGNIYSHPVPSCIGAPARLPPHNPRL---------H 232

  Fly   308 MPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQPS 372
            .|.               .|..:.|.|.:...:..:     ::|.|:|..|     .||.  .||
Zfish   233 TPA---------------KHTHLKTEPVLGSVMDSI-----NIKGLEDHSE-----GDVA--SPS 270

  Fly   373 STSGGVAQVEADSASSQLSDRCYNNVVNNITGIP--GDVKVNSRLDEYINCGSISIPSNEYDCAN 435
            ||.                           |..|  |.::....||:
Zfish   271 STG---------------------------TQDPLLGLLEGRDDLDK------------------ 290

  Fly   436 ADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKA 500
                :.|.||....||||||.||..||.||::||.||||:||...||.|||.|:||:|.::||||
Zfish   291 ----EEKPEPEAIYETNCHWESCSKEFDTQEQLVHHINNEHIHGEKKEFVCHWKDCSREQRPFKA 351

  Fly   501 QYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRA 565
            ||||||||||||||||||||||||.||||||||||||||||||||||.||:.||:||||||||||
Zfish   352 QYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRA 416

  Fly   566 KHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHK--------GLPLNDAN 622
            ||||||||||||||||.||||||||||||||||||||||.|.:..|||:        ||.....:
Zfish   417 KHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPGLTTAGQS 481

  Fly   623 SRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTY 687
            |.|.......|.:    |....:.|:.|     .|.||...:|..||....|.:.
Zfish   482 SELLIEKEERNRE----DCKLLAPDNTL-----KSQPSPGGQSSCSSERSPLGSA---------- 527

  Fly   688 SPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTI----GGSVLARQRFRGRLQ 748
            :.:|....:||:...:.:|          |....:.||...|.|:.    ||..::.|..: ||:
Zfish   528 NNNDSGVEMNLNAAGSLED----------LTTQEDSGNAGVSESSATISSGGMCMSVQALK-RLE 581

  Fly   749 TKGINSSTIMLCNIPESNRTFGISELNQRITELKM-----EPGTDAEIKIPKLPNT--TIGGYTE 806
                                      |.:|.:||.     .||.:|..|:|.|..|  .:.....
Zfish   582 --------------------------NLKIDKLKQIRRPTPPGRNAGNKLPALSATGEMMSMCAP 620

  Fly   807 DPLQNQTSFRNTVSNKQGTVSG-SIQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSIPTMRPN 870
            .||.:........:...|.|:| |.....||.|..|:.|:.|  ..|||||..|...|.......
Zfish   621 SPLLSNRRVMELSAPDMGGVTGMSCPPNDRRGSGTSSLSSAY--TVSRRSSMVSPYLSSRRSSDV 683

  Fly   871 PSCNSTASFY---DPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNKSLNACINK------ 926
            ..|.|.....   ||:||..|:|:..      |.:.....|||.|......||.|....
Zfish   684 SHCQSVMGGEVPGDPLSPQNSQRAGL------CQNSGGLPGLPSLTPAQQYSLKAKYAAATGGPP 742

  Fly   927 ----PNIGVQG-----VGIYN--SSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRFSVPSYMHS 980
                ||:...|     ||...  ...|.||.          ||:..:..|:..:...:...|.|
Zfish   743 PTPLPNMDQAGTPARHVGFLRECQGQPLPPF----------LQQGGTRRHSANAEYGTGVIYPH- 796

  Fly   981 LHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDP--LTNISRFSTTPHSFDINVGKTNNIASS 1043
                           :|..:|.||.:|||.:. .||  |..:.||::..   ::::....|....
Zfish   797 ---------------QAPGNNTRRASDPVRSA-ADPQGLPKVQRFNSLS---NVSLMSRRNALQQ 842

  Fly  1044 INKD-NLRKDLFT---------VSIKA-------------------DMAMTSDQH-PNERINLDE 1078
            ...| .|.:.:::         |.::|                   |.:....|| |::...|..
Zfish   843 CGSDAALSRHMYSPRPPSITENVMMEAMGMDGNTEGRQQGNMIPGGDRSYMGYQHNPHQASQLSP 907

  Fly  1079 VEE-LILPDEMLQYLNLVKDDTNHLEKEHQ---AVPVGSNVSETIASN----------------- 1122
            .:| |...|::.|         :.::.::|   :...|......||:|
Zfish   908 GQESLGCIDQVYQ---------SQMQGQYQREESCSTGVMGQTDIANNLLQQAEYGMSTCQLSPS 963

  Fly  1123 --HYREQSN-------------------------IYYTNKQILTPPSNVDIQPNTTKFTVQDKFA 1160
              ||..|.:                         .:||.:.|..|.||    ||..:.||:.:..
Zfish   964 GPHYPSQGDGSGPWGQTNQLHSPGMQYQGAGMQGQHYTQQGIYDPTSN----PNLQRVTVKPEQF 1024

  Fly  1161 MTAVGGSFSQRELSTL-----------------AVPNEHGHAKCESFHH-------------QSQ 1195
            ..::|||.|.:....|                 .:.|....|.|: |||             ||.
Zfish  1025 HPSMGGSSSCQNTKALHQNRHNANMQTYPLQGQGIMNRSSSASCD-FHHSQMGTQPNQGGSFQSG 1088

  Fly  1196 KYMNTDIGSKQQSALPSAHQRQTEKSNY---------NQIIDSSMTSLPELNVD----------- 1240
            ..:|..:...::|..|....::....||         .|..:.|::..|: .:|
Zfish  1089 TGINLALAESRRSQTPMHQMKEMMVRNYVQSQQALLWEQQQEQSVSEKPD-GMDMGQTQMMQHSP 1152

  Fly  1241 -------SIYPRN-----ETENIF-----KVHGDHDNEIQCGII--------------------- 1267
                   ::||.|     ..:|:.     :|.|....::|....
Zfish  1153 QHQQANQNLYPGNTYQGYPNQNLMSPQQNRVPGSVKEQMQSSCYGPDMIPRPPQVRKSLSRQNSL 1217

  Fly  1268 ------------------------------------SQSQMSPSTNLNND--------------- 1281
                                                .|.|...|.|.||:
Zfish  1218 SQQAGGAYLGSPPHLSPVHSTASPRRGVRLPPVQQQQQQQQQHSENFNNNNNPMYYSGQIHMHHD 1282

  Fly  1282 ----------GQFSTVNMQPIT--TSKLFP-PEPQKIVCDTQASNTSVMHLDTYQRTLEYV---- 1329
                      .|....:..|.|  ||..:| |.|.         :.::.|||.....:::.
Zfish  1283 LEKTPEGPCLAQQHLTSSDPTTKPTSISYPDPAPM---------SNALEHLDLENAQIDFTSIID 1338

  Fly  1330 -QSCQNWMETN-----NTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTSLLE 1388
             |...::...|     |..::|..|....|.|:...|...|        ||.|.||::.||||..
Zfish  1339 DQEPSSYSPINAPIGHNQCSSQTSSRLTTPQNSITLPSGLS--------NMAIGDMSSMLTSLAG 1395

  Fly  1389 ENRYLQMM 1396
            ||:||..:
Zfish  1396 ENKYLNTL 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	25/26 (96%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:290200	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
gli1	NP_840081.2	SFP1	<364..454	CDD:227516	83/89 (93%)
		C2H2 Zn finger	370..392	CDD:275368	20/21 (95%)
		C2H2 Zn finger	400..423	CDD:275368	19/22 (86%)
		C2H2 Zn finger	431..452	CDD:275368	19/20 (95%)
		Med15	853..>1233	CDD:312941	58/394 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6130
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1687
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24322
orthoMCL	1	0.900	-	-		OOG6_104319
Panther	1	1.100	-	-	LDO	PTHR45718
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	1	1.000	-	-		X2040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.080