Protein Alignment ci and Gli2

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001100639.2
• Gene: Gli2 / 304729
• RGDID: 1309270
• Length: 1544
• Species: Rattus norvegicus
• Alignment Length: 1766
• Identity: 483/1766 - (27%)
• Similarity: 663/1766 - (37%)
• Gaps: 644/1766 - (36%)

  Fly    23 RRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAG 87
            ::|..:|.||   |.:....|..|..:..|..||..|                         :..
  Rat    30 KKACPLAVAA---PAAAVAAQGVPQQLLPSFHVPLPI-------------------------DMR 66

  Fly    88 HQ---HNHQPQHVHNIN----VTGQP--HDF-------HPAYRIPGYMEQLYSLQRTNSASSFHD 136
            ||   :::.|..||.::    ::|.|  .|.       |||.  ||           .|..|.|.
  Rat    67 HQEGRYHYDPHPVHGVHGPPTLSGSPVISDISLIRLSPHPAG--PG-----------ESPFSAHH 118

  Fly   137 PYVNCASAFHL-------------AGLGLGSAD----FLGSRGLSSLGE--------LHNAAVAA 176
            ||:|.....:|             |..||..||    .|..|||.||..        .|...:.|
  Rat   119 PYMNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMA 183

  Fly   177 A----------AAGSLAST----DFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD-SF 226
            :          .:|..||.    |:...||.: |..|||     :...:|||||||.||.|| |.
  Rat   184 SHPTPYGDILMQSGGAASAPHLHDYLNPVDAS-RFSSPR-----VTPRLSRKRALSISPLSDASL 242

  Fly   227 DINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTRLQQIQAHLLRASAGLL 290
            |:..|||.|||||...:|.||.||||||||||:||.||:| .:..|.                 :
  Rat   243 DLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHP-----------------I 290

  Fly   291 NPMTPQQVAAS----GFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLK 351
            ||:..||:.:.    |.:.||.|.                  .|..|||.   ::|.|....|:
  Rat   291 NPVAYQQILSQQRGLGSAFGHTPP------------------LIQPSPTF---LAQQPMTLTSI- 333

  Fly   352 NLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLD 416
                          .||.|..|.|...  :...:.:.|.|:...::.||.|| |....||.:..:
  Rat   334 --------------TVPTQLGSNSSNC--ISDANQNKQNSESAVSSTVNPIT-IHKRSKVKTEAE 381

  Fly   417 EYINCGSISIPSNEY-DC-ANADTTDIKDEPGDFI-ETNCHWRSCRIEFITQDELVKHINNDHIQ 478
            .......:.:...:. |. .:.|..|.|.|....| ||||||..|..|:.||::||.||||:||.
  Rat   382 GLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIH 446

  Fly   479 TNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTG 543
            ..||.|||||:.|||.:|||||||||||||||||||||||||||||.||||||||||||||||||
  Rat   447 GEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTG 511

  Fly   544 EKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFY 608
            ||||.||:.||:||||||||||||||||||||||||||.||||||||||||||||||||||.:.:
  Rat   512 EKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAH 576

  Fly   609 ANKKHKGLPLNDANSR---LQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSS 670
            ..||.:    ||.:.|   |::|.                 |:..|...|...|....|:  ||:
  Rat   577 VTKKQR----NDVHLRAPLLKENG-----------------DNEAGAEPGGRGPEESVEA--SST 618

  Fly   671 NH------HLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNAS 729
            :|      |:......|..|...||.  |::       :|..:      |..|.::.|..:|...
  Rat   619 SHTAEDCLHIKAIKTESSGLCQSSPG--AQS-------SCSSE------PSPLGSVPNNDSGVEM 668

  Fly   730 ASTIGGSVLARQRFRGRL-----QTKGINSSTIMLCNIPESNRTFGISELNQRIT------ELKM 783
            ..|..||:       |.|     .:.|.::|.:.   :|.:    |..:|.:.:|      :||.
  Rat   669 PGTGPGSL-------GDLTALDDTSPGADTSALA---VPST----GGLQLRKHMTTMHRFEQLKR 719

  Fly   784 E-----------PGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNT--------VSNKQ----GT 825
            |           .|.....:..|||...:.|   ..|:|   |.||        :.|::    ..
  Rat   720 EKLKSLKDSCSWAGPAPHTRNTKLPPLPVNG---SVLEN---FNNTGGCGPAGLLPNQRLPELTE 778

  Fly   826 VSGSIQGQFRRDSQNSTASTYYGSMQSRRSS---------QSSQVSSIPTMRPNPSCNSTASFYD 881
            |:...|.|.||||..||.|:.|  ..|||||         :||:.|.:..:||:.:  |:|..||
  Rat   779 VTMLSQLQERRDSSTSTMSSAY--TVSRRSSGISPYFSSRRSSEASPLGGIRPHNA--SSADSYD 839

  Fly   882 PISPGCSRRSSQMS----NGANCNSFT-------------STSG-----LPVLNKESNKSLNACI 924
            |||...|||||:.|    .|....:.|             :|.|     ||.|::.|.::..|.:
  Rat   840 PISTDASRRSSEASQCSGGGPGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLDRVSLRTRLALL 904

  Fly   925 NKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRF-SVPSYMHSLHIKNNKP 988
            :.|...:.|      :.|.|         |...:..|...:|...|.. :.|:..|.
  Rat   905 DAPERALPG------ACPQP---------LGPRRGSDGPTYNHGHGYVGAAPALPHE-------- 946

  Fly   989 VGENEFDKAIASNARRQTDP-----------VPNINLDPLT------------------NISR-- 1022
             |.|...:. ||:..|:.||           :.|:|..||.                  :::|
  Rat   947 -GPNGSTRR-ASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPCTDRRGLHLQSHPSVDGSLTRHA 1009

  Fly  1023 FSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVEELILPDE 1087
            :|..|.|.:.|| ....:|:.:....|..||..|.                      ::|:|||:
  Rat  1010 YSPRPPSINENV-VMEAVAAGVEGAGLESDLGLVE----------------------DDLVLPDD 1051

  Fly  1088 MLQYL-----NLVKDDTNH-------------------LEKEHQAVPVGSNVSETI-----ASNH 1123
            ::||:     ..:.|.|..                   |:...:.....||:|.:.     ....
  Rat  1052 VVQYIKAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSAPGLGGCQLS 1116

  Fly  1124 YREQSNIYYTNKQI----------------LTPP----SNV------------------------ 1144
            |...|::..:|..:                :.||    ||:
  Rat  1117 YSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNLVQQKPAFAHYPGYSPQALQSGSGG 1181

  Fly  1145 --DIQPN------------------------------TTKFTVQDKFAMT-------AVGGSFSQ 1170
              ..||:                              |...:.|..::.|       .|.||.:|
  Rat  1182 LDSTQPHLQLRGAPSASRGSYTQQPRLPATGSQCLGVTAAMSPQANYSQTHHQLSPNVVSGSLNQ 1246

  Fly  1171 --RELSTLA--------------VPNE---HGHAK----------CESFHHQSQKYMNTDIGSKQ 1206
              ...|.:|              |||.   .||.:          ..|..|....|...| |.:|
  Rat  1247 FAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIASSSLAAVSQPHPVLGYPQQD-GYQQ 1310

  Fly  1207 QSALPSAHQRQTEKSNYN---------------------------------------QIIDSSMT 1232
            .|.|||:||....:|..|                                       .::.|:..
  Rat  1311 VSGLPSSHQPSFMESQQNTGFGLMQPRPPLEPNTASRHRGVRSGQQQQQLYARTAGQAVVTSANQ 1375

  Fly  1233 SLPEL-------NVDSIYP-------RNETENIFKVHGD-HDNEIQ---------------CGII 1267
            ...|.       .|.|:.|       |::.:|....:|. |..|..               |...
  Rat  1376 ETAEAMPKGTAGTVVSLTPQPSQDTGRSQDQNTLYYYGQIHMYEQNGGCPAMQPQPPQPQGCSDN 1440

  Fly  1268 SQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCD------------TQASNTSVMHLD 1320
            .|.:..||..:|...  |||:.|.:        ||.:|..|            :.|.:.|::|
  Rat  1441 IQPEPLPSPGVNQVS--STVDSQLL--------EPPQIDFDAIMDDGDHSSLFSGALSPSLLH-- 1493

  Fly  1321 TYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTS 1385
                               |.|.|  .|....|.|:...|.:     |...:||.:.||::.|||
  Rat  1494 -------------------NLSQN--SSRLTTPRNSLTLPSI-----PVGISNMAVGDMSSMLTS 1532

  Fly  1386 LLEENRYLQMM 1396
            |.|||::|.||
  Rat  1533 LAEENKFLNMM 1543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	17/17 (100%)
		SFP1	<513..603	CDD:227516	83/89 (93%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:463886	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
Gli2	NP_001100639.2	SFP1	<481..571	CDD:227516	83/89 (93%)
		C2H2 Zn finger	487..509	CDD:275368	20/21 (95%)
		C2H2 Zn finger	517..540	CDD:275368	19/22 (86%)
		C2H2 Zn finger	548..569	CDD:275368	19/20 (95%)