DRSC/TRiP Functional Genomics Resources

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Protein Alignment ci and Gli2

DIOPT Version :9

Sequence 1:NP_524617.3 Gene:ci / 43767 FlyBaseID:FBgn0004859 Length:1397 Species:Drosophila melanogaster
Sequence 2:XP_017454273.1 Gene:Gli2 / 304729 RGDID:1309270 Length:1544 Species:Rattus norvegicus


Alignment Length:1766 Identity:483/1766 - (27%)
Similarity:663/1766 - (37%) Gaps:644/1766 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 RRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAG 87
            ::|..:|.||   |.:....|..|..:..|..||..|                         :..
  Rat    30 KKACPLAVAA---PAAAVAAQGVPQQLLPSFHVPLPI-------------------------DMR 66

  Fly    88 HQ---HNHQPQHVHNIN----VTGQP--HDF-------HPAYRIPGYMEQLYSLQRTNSASSFHD 136
            ||   :::.|..||.::    ::|.|  .|.       |||.  ||           .|..|.|.
  Rat    67 HQEGRYHYDPHPVHGVHGPPTLSGSPVISDISLIRLSPHPAG--PG-----------ESPFSAHH 118

  Fly   137 PYVNCASAFHL-------------AGLGLGSAD----FLGSRGLSSLGE--------LHNAAVAA 176
            ||:|.....:|             |..||..||    .|..|||.||..        .|...:.|
  Rat   119 PYMNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMA 183

  Fly   177 A----------AAGSLAST----DFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD-SF 226
            :          .:|..||.    |:...||.: |..|||     :...:|||||||.||.|| |.
  Rat   184 SHPTPYGDILMQSGGAASAPHLHDYLNPVDAS-RFSSPR-----VTPRLSRKRALSISPLSDASL 242

  Fly   227 DINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTRLQQIQAHLLRASAGLL 290
            |:..|||.|||||...:|.||.||||||||||:||.||:| .:..|.                 :
  Rat   243 DLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHP-----------------I 290

  Fly   291 NPMTPQQVAAS----GFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLK 351
            ||:..||:.:.    |.:.||.|.                  .|..|||.   ::|.|....|: 
  Rat   291 NPVAYQQILSQQRGLGSAFGHTPP------------------LIQPSPTF---LAQQPMTLTSI- 333

  Fly   352 NLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLD 416
                          .||.|..|.|...  :...:.:.|.|:...::.||.|| |....||.:..:
  Rat   334 --------------TVPTQLGSNSSNC--ISDANQNKQNSESAVSSTVNPIT-IHKRSKVKTEAE 381

  Fly   417 EYINCGSISIPSNEY-DC-ANADTTDIKDEPGDFI-ETNCHWRSCRIEFITQDELVKHINNDHIQ 478
            .......:.:...:. |. .:.|..|.|.|....| ||||||..|..|:.||::||.||||:||.
  Rat   382 GLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIH 446

  Fly   479 TNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTG 543
            ..||.|||||:.|||.:|||||||||||||||||||||||||||||.||||||||||||||||||
  Rat   447 GEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTG 511

  Fly   544 EKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFY 608
            ||||.||:.||:||||||||||||||||||||||||||.||||||||||||||||||||||.:.:
  Rat   512 EKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAH 576

  Fly   609 ANKKHKGLPLNDANSR---LQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSS 670
            ..||.:    ||.:.|   |::|.                 |:..|...|...|....|:  ||:
  Rat   577 VTKKQR----NDVHLRAPLLKENG-----------------DNEAGAEPGGRGPEESVEA--SST 618

  Fly   671 NH------HLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNAS 729
            :|      |:......|..|...||.  |::       :|..:      |..|.::.|..:|...
  Rat   619 SHTAEDCLHIKAIKTESSGLCQSSPG--AQS-------SCSSE------PSPLGSVPNNDSGVEM 668

  Fly   730 ASTIGGSVLARQRFRGRL-----QTKGINSSTIMLCNIPESNRTFGISELNQRIT------ELKM 783
            ..|..||:       |.|     .:.|.::|.:.   :|.:    |..:|.:.:|      :||.
  Rat   669 PGTGPGSL-------GDLTALDDTSPGADTSALA---VPST----GGLQLRKHMTTMHRFEQLKR 719

  Fly   784 E-----------PGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNT--------VSNKQ----GT 825
            |           .|.....:..|||...:.|   ..|:|   |.||        :.|::    ..
  Rat   720 EKLKSLKDSCSWAGPAPHTRNTKLPPLPVNG---SVLEN---FNNTGGCGPAGLLPNQRLPELTE 778

  Fly   826 VSGSIQGQFRRDSQNSTASTYYGSMQSRRSS---------QSSQVSSIPTMRPNPSCNSTASFYD 881
            |:...|.|.||||..||.|:.|  ..|||||         :||:.|.:..:||:.:  |:|..||
  Rat   779 VTMLSQLQERRDSSTSTMSSAY--TVSRRSSGISPYFSSRRSSEASPLGGIRPHNA--SSADSYD 839

  Fly   882 PISPGCSRRSSQMS----NGANCNSFT-------------STSG-----LPVLNKESNKSLNACI 924
            |||...|||||:.|    .|....:.|             :|.|     ||.|::.|.::..|.:
  Rat   840 PISTDASRRSSEASQCSGGGPGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLDRVSLRTRLALL 904

  Fly   925 NKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGRF-SVPSYMHSLHIKNNKP 988
            :.|...:.|      :.|.|         |...:..|...:|...|.. :.|:..|.        
  Rat   905 DAPERALPG------ACPQP---------LGPRRGSDGPTYNHGHGYVGAAPALPHE-------- 946

  Fly   989 VGENEFDKAIASNARRQTDP-----------VPNINLDPLT------------------NISR-- 1022
             |.|...:. ||:..|:.||           :.|:|..||.                  :::|  
  Rat   947 -GPNGSTRR-ASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPCTDRRGLHLQSHPSVDGSLTRHA 1009

  Fly  1023 FSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVEELILPDE 1087
            :|..|.|.:.|| ....:|:.:....|..||..|.                      ::|:|||:
  Rat  1010 YSPRPPSINENV-VMEAVAAGVEGAGLESDLGLVE----------------------DDLVLPDD 1051

  Fly  1088 MLQYL-----NLVKDDTNH-------------------LEKEHQAVPVGSNVSETI-----ASNH 1123
            ::||:     ..:.|.|..                   |:...:.....||:|.:.     ....
  Rat  1052 VVQYIKAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSAPGLGGCQLS 1116

  Fly  1124 YREQSNIYYTNKQI----------------LTPP----SNV------------------------ 1144
            |...|::..:|..:                :.||    ||:                        
  Rat  1117 YSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNLVQQKPAFAHYPGYSPQALQSGSGG 1181

  Fly  1145 --DIQPN------------------------------TTKFTVQDKFAMT-------AVGGSFSQ 1170
              ..||:                              |...:.|..::.|       .|.||.:|
  Rat  1182 LDSTQPHLQLRGAPSASRGSYTQQPRLPATGSQCLGVTAAMSPQANYSQTHHQLSPNVVSGSLNQ 1246

  Fly  1171 --RELSTLA--------------VPNE---HGHAK----------CESFHHQSQKYMNTDIGSKQ 1206
              ...|.:|              |||.   .||.:          ..|..|....|...| |.:|
  Rat  1247 FAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIASSSLAAVSQPHPVLGYPQQD-GYQQ 1310

  Fly  1207 QSALPSAHQRQTEKSNYN---------------------------------------QIIDSSMT 1232
            .|.|||:||....:|..|                                       .::.|:..
  Rat  1311 VSGLPSSHQPSFMESQQNTGFGLMQPRPPLEPNTASRHRGVRSGQQQQQLYARTAGQAVVTSANQ 1375

  Fly  1233 SLPEL-------NVDSIYP-------RNETENIFKVHGD-HDNEIQ---------------CGII 1267
            ...|.       .|.|:.|       |::.:|....:|. |..|..               |...
  Rat  1376 ETAEAMPKGTAGTVVSLTPQPSQDTGRSQDQNTLYYYGQIHMYEQNGGCPAMQPQPPQPQGCSDN 1440

  Fly  1268 SQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCD------------TQASNTSVMHLD 1320
            .|.:..||..:|...  |||:.|.:        ||.:|..|            :.|.:.|::|  
  Rat  1441 IQPEPLPSPGVNQVS--STVDSQLL--------EPPQIDFDAIMDDGDHSSLFSGALSPSLLH-- 1493

  Fly  1321 TYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTS 1385
                               |.|.|  .|....|.|:...|.:     |...:||.:.||::.|||
  Rat  1494 -------------------NLSQN--SSRLTTPRNSLTLPSI-----PVGISNMAVGDMSSMLTS 1532

  Fly  1386 LLEENRYLQMM 1396
            |.|||::|.||
  Rat  1533 LAEENKFLNMM 1543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ciNP_524617.3 zf-H2C2_2 503..530 CDD:290200 25/26 (96%)
C2H2 Zn finger 519..541 CDD:275368 20/21 (95%)
zf-H2C2_2 533..560 CDD:290200 22/26 (85%)
C2H2 Zn finger 549..572 CDD:275368 19/22 (86%)
C2H2 Zn finger 580..601 CDD:275368 19/20 (95%)
Gli2XP_017454273.1 zf-H2C2_2 471..498 CDD:290200 25/26 (96%)
C2H2 Zn finger 487..509 CDD:275368 20/21 (95%)
zf-H2C2_2 501..528 CDD:290200 22/26 (85%)
C2H2 Zn finger 517..540 CDD:275368 19/22 (86%)
C2H2 Zn finger 548..569 CDD:275368 19/20 (95%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351316
Domainoid 1 1.000 111 1.000 Domainoid score I6104
eggNOG 1 0.900 - - E33208_3BFAM
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 444 1.000 Inparanoid score I1590
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003548
OrthoInspector 1 1.000 - - otm44549
orthoMCL 1 0.900 - - OOG6_104319
Panther 1 1.100 - - O PTHR45718
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2040
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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