DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ci and gli2a

DIOPT Version :9

Sequence 1:NP_524617.3 Gene:ci / 43767 FlyBaseID:FBgn0004859 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_571042.1 Gene:gli2a / 30154 ZFINID:ZDB-GENE-990706-8 Length:1439 Species:Danio rerio


Alignment Length:1617 Identity:464/1617 - (28%)
Similarity:634/1617 - (39%) Gaps:450/1617 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHN--HQP-----QHVHNINVT 103
            ||........||::.....:|..|   :|    ..|....|.|..:  |.|     :| |.....
Zfish     6 PTSTEKKELKPSVLDGSSFTDLPK---KP----SPTTASRAPHLFSTFHTPIPIDMRH-HEGRYH 62

  Fly   104 GQPHDFHPAYRIPGY----------MEQLYSLQRTNSASSFH--DPYVNCASAFHL--------- 147
            .:||..||.:...|.          :.:|.........|.|:  .||||.....:|         
Zfish    63 YEPHPLHPMHGPHGLAGSPVISDISLIRLSPHAAATGESPFNPPHPYVNPHMEHYLRSVHSSPTL 127

  Fly   148 ----AGLGLGSADF----LGSRGL-----------------------SSLGELHNAAVAAAAAGS 181
                |..||..|:.    |..|.|                       |..|:|.....||||   
Zfish   128 SMISAARGLSPAELTHEHLKERSLFGLPPPPPGANPSEYYHLIASHRSPYGDLLMQTGAAAA--- 189

  Fly   182 LASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD-SFDINSMIRFSPNSLATIMNG 245
             ...|:...||.: |..|||     :...:|||||||.||.|| |.|:.:|||.|||||...:|.
Zfish   190 -HLPDYMSPVDMS-RFPSPR-----LTPRVSRKRALSISPVSDASIDLQTMIRTSPNSLVAYINN 247

  Fly   246 SRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTP--------QQVAASG 302
            ||.|||||.||||:|..|::|                   |....:|:||        ||...:.
Zfish   248 SRSSSAASSSYGHLSVGAISP-------------------SFTFPHPITPVAYHQLLSQQRGLNA 293

  Fly   303 FSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVV 367
            |  ||.|           |.|.       .||.::.. .|...||.:|.|...            
Zfish   294 F--GHTP-----------PLLQ-------PSPALSSR-QQTLVAAAALNNTTS------------ 325

  Fly   368 PEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSIS-IPSNEY 431
                ||||...|....:|:.:...|...::.||.:......||..:.....|:.||.. :...| 
Zfish   326 ----SSTSSSTADTSTESSQNAGGDPAVSSTVNPMIFKRSKVKTEAEGPHPISPGSQDHLELRE- 385

  Fly   432 DCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEK 496
               ..|..:.|.||....||||||..|..|:.|||:||.||:||||...||.|||||.:|:|.:|
Zfish   386 ---ELDKDECKQEPEAVYETNCHWEGCAKEYDTQDQLVHHISNDHIHGEKKEFVCRWVECSREQK 447

  Fly   497 PFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNA 561
            ||||||||||||||||||||||||||||.||||||||||||||||||||||.||:.||:||||||
Zfish   448 PFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNA 512

  Fly   562 SDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKG-LPLNDANSRL 625
            |||||||||||||||||:||.||||||||||||||||||||||.|.:..||.:| .|......:.
Zfish   513 SDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDAPPKPHPPKG 577

  Fly   626 QQNNSRHNLQ---------EHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRAS 681
            ...|..|...         |.|..:....:..|:        .:||:|:.:      :.......
Zfish   578 NGENEAHTKHVRGRTDGSGEANSTTRGVEDCQHV--------KTIKTENTV------MYQSSPGG 628

  Fly   682 DSLLTYSPDDLAENLNLDDGWNCDDDVDVA--------------DLPIVLRAMVNIGNGNASAST 732
            .|..:..|..|....|.|.|      |::|              |.|:|    .:.|:...||  
Zfish   629 QSSCSSEPSPLGSATNNDSG------VEMAMHSGGSLGDLSALDDTPVV----DSTGSPGTSA-- 681

  Fly   733 IGGSVLARQRFRGRLQTKGINSSTIML-------CNIPESNRTFGISELNQRITELKMEPGTDAE 790
             |..:..|:...|.||.:.|....:..       .|.|...|.          |:|...|..|:.
Zfish   682 -GVGLQLRKNRAGLLQLEHIKKEKLKTVRDSCSWANAPPQVRN----------TKLPPIPSIDSL 735

  Fly   791 IKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQ---- 851
            :..|.: .|.:.......|.:.:|:..|:.|         |...||||..||.|:.|.|.:    
Zfish   736 LDAPNM-GTQMSVPPTQHLGDLSSYEMTMLN---------QLHERRDSSTSTMSSAYISRRSSGI 790

  Fly   852 -----SRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPV 911
                 |||||::||..    :|.|..  |:|..|||||...|||||:.|   .|.   .|.|||.
Zfish   791 SPCYSSRRSSEASQFG----VRNNNV--SSADSYDPISTDLSRRSSEAS---QCG---GTGGLPS 843

  Fly   912 ---LNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLK-RL----QRKDSEYHNFT 968
               |....:.||.|.......|.          ||.|..::...:|| |:    ..:||..|   
Zfish   844 LLNLTPAQHYSLKAKYAAATGGA----------PPTPLPNMDRMSLKTRMAMYNDSQDSSAH--- 895

  Fly   969 SGRFSVPSYMHSLHIKNNKPVGENEF-------DKAIASNARRQTDPVPNINLDPLT--NISRFS 1024
                    ..|:..:.|::...:..:       .:..|:..||.:|||....||||:  .:.|| 
Zfish   896 --------LHHAQGVVNSRRCSDTGYGAPGMMPHEVPANLPRRASDPVRRTTLDPLSLPRVQRF- 951

  Fly  1025 TTPHSFDINVGKTNNIASSINKDNL---RKDLFTVSIKADMAMTSDQHP--------NERINLDE 1078
                          |..|::|...|   .:..|.:........:..:||        :|.|.::.
Zfish   952 --------------NSISNMNLSRLPAYDRRAFNMQNNTWSDGSLHRHPFSQRPPSISENILMEN 1002

  Fly  1079 V---------EELILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTN 1134
            :         ::|:|||:|:|||.....::||    ...:.|....:.....|...:|...|...
Zfish  1003 MATDGGDQQGDDLVLPDDMVQYLRSQNGNSNH----DSGISVNGGHALEFHGNMTSQQQQFYGQR 1063

  Fly  1135 K----------------QILTP----PSNVDIQPNTTKFTVQDKFAMTAVGGSFSQRELSTL-AV 1178
            :                ||..|    .:|:.:|.|.......|  |::.|.....|:....| .|
Zfish  1064 RMGMAGINGSHVEPVPEQIADPQGMNKNNMPVQWNEVSSGSAD--AVSRVPKQQQQQLRGNLTVV 1126

  Fly  1179 PNEHGHAKCESFHHQSQKY-MNTDIGSKQQSALPSAH-QRQTEKSNYNQII-------------- 1227
            ..:......:.|....|.. |:.::.|.|| |.|..: ||......:.|.|              
Zfish  1127 QQKQNFGSYQGFGSNQQIVPMSQNLASLQQ-AYPQRNIQRMNTVQQFRQSISNPCQNIGEQVNRQ 1190

  Fly  1228 DSSMTSLPELNVDSIYPRN-------ETENIFKVHGDHDNEIQ----------------CGIISQ 1269
            |.|..|...|..:|:.|.|       |.:| ::.:..|.|.|.                .|:|..
Zfish  1191 DLSYNSNQRLICNSMGPPNGRMVQNQELQN-YRSNLMHMNNINQQNYVPLTQTAFQNAGRGLIQP 1254

  Fly  1270 SQMSPSTNLNNDGQFSTVNMQP-------ITTSKLFPPEPQKIVCDTQASNT----SVMHLDTYQ 1323
            ...|....||.....|.: :||       :.:|:..|..|.::...:..:.|    ..:|:  ..
Zfish  1255 RPPSEPKPLNRQHSGSGM-VQPNGCSLSNVNSSEASPKRPGEVGQHSNGNGTMYYSGEIHM--LD 1316

  Fly  1324 RTLEY---VQSCQNWMETNNTST------NQI-------QSLPGMPV---------------NNT 1357
            ..::|   :..|.|.....:.||      ||:       |||....:               :.|
Zfish  1317 NGIDYGSPMSPCTNQAPVASVSTMASPGVNQVTSTVDSTQSLDHTQIDFDAMLDDGDHSSLMSGT 1381

  Fly  1358 LFPDVSSS--------THPYHGT----------NMVINDMTTSLTSLLEENRYLQMM 1396
            |.|.:..|        |.|.:..          ||.|.||::.||:|.||:::|.||
Zfish  1382 LSPGLLQSISQNSSRLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMM 1438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ciNP_524617.3 zf-H2C2_2 503..530 CDD:290200 25/26 (96%)
C2H2 Zn finger 519..541 CDD:275368 20/21 (95%)
zf-H2C2_2 533..560 CDD:290200 22/26 (85%)
C2H2 Zn finger 549..572 CDD:275368 19/22 (86%)
C2H2 Zn finger 580..601 CDD:275368 19/20 (95%)
gli2aNP_571042.1 C2H2 Zn finger 441..462 CDD:275368 16/20 (80%)
zf-H2C2_2 454..481 CDD:290200 25/26 (96%)
C2H2 Zn finger 470..492 CDD:275368 20/21 (95%)
zf-H2C2_2 484..511 CDD:290200 22/26 (85%)
C2H2 Zn finger 500..523 CDD:275368 19/22 (86%)
C2H2 Zn finger 531..552 CDD:275368 19/20 (95%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 112 1.000 Domainoid score I6130
eggNOG 1 0.900 - - E33208_3BFAM
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 431 1.000 Inparanoid score I1687
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003548
OrthoInspector 1 1.000 - - otm24322
orthoMCL 1 0.900 - - OOG6_104319
Panther 1 1.100 - - O PTHR45718
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2040
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.820

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