Protein Alignment ci and Glis1

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001100173.2
• Gene: Glis1 / 298732
• RGDID: 1308030
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 890
• Identity: 244/890 - (27%)
• Similarity: 310/890 - (34%)
• Gaps: 332/890 - (37%)

  Fly   161 RGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRA-SISRKRALSSSPYSD 224
            ||.:.| |.|.|...|.:.|...        |||.|...||.|....|| .:.|.|  |...||.
  Rat    25 RGPAGL-EAHMAFRIAVSGGGCG--------DGNPRDLLPRLPVPPPRAHDLLRPR--SPRDYSV 78

  Fly   225 SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATAL---------NPMSHVHSTRLQQIQA 280
            |                    ..|....:|||||.|..:|         :|..|
  Rat    79 S--------------------KAGGGKVNGSYGHSSEKSLLDLDLAEGPSPSCH----------- 112

  Fly   281 HLLRASAGLLNPM-TPQQVAASGFSIGHMPTSASLRVNDVHPNLSD--------------SHIQI 330
                  .||..|. ||.       ..||.|....| ::..|||.|.              .||:.
  Rat   113 ------QGLFLPAGTPP-------PRGHPPVCERL-LHFPHPNRSPRPQATYANGSLPAAQHIKQ 163

  Fly   331 TTSPTVTKDVS---------QVPAAAFSLKNLD-DAREKKGPFKD--VVPEQPSSTSGGVAQVEA 383
            ...|.....||         :.|.:.....:|| ..|....|...  :|..:|.|:.|  .|.||
  Rat   164 EALPDYQAMVSAHTPLPTHCRAPLSMGLHSDLDFPGRGLTNPAPSCYLVGNEPISSLG--PQPEA 226

  Fly   384 ---------------DSASSQLSDRCYNNVVNNI-----------------TGIPGDV------- 409
                           ...||..|..|.::.:|.:                 ..:|||:
  Rat   227 HLPEGSLKRCCLLGLPPTSSASSSPCASSDINPVIHSSQTALVSCVNGLRSPPLPGDLGGPPKRS 291

  Fly   410 -------KVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGD-FIE---------------- 450
                   .|:|...|    ||:.:.:    |..:..  :|.||.| |.|
  Rat   292 RHGPGPGPVSSDGQE----GSLQLEA----CRKSGF--LKQEPMDEFSELFAPHQQGLPPPYPLP 346

  Fly   451 -----------------------TNCHWRSCRIEFITQDELVKHINNDHIQTNK-KAFVCRWEDC 491
                                   ..|.|..|...:..|:|||:||...||...| :.|.|.|..|
  Rat   347 QLPTGPSLGGLGLGLAGRMAAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGC 411

  Fly   492 TRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSK 556
            .|..|||.|:|.|::|||.|:||||:||.||||.||:|||||||.|||||||||||.|::|||.|
  Rat   412 VRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQK 476

  Fly   557 AFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKK-HKG----- 615
            ||||:||||||| |||.:.|||.|:.|||:||||||||||||||.....|....|| |.|
  Rat   477 AFSNSSDRAKHQ-RTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPEA 540

  Fly   616 ---------------LPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSES 665
                           .||..:..:..|..|    ||......|.|.....|...|..|||    .
  Rat   541 AVLSECLALQQLQASTPLPASRGKGSQTLS----QELLPGVYPGSVTPQNGLASGILSPS----H 597

  Fly   666 DISS----------SNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAM 720
            |:.|          |:|||             ||...||:..  ||..          |.:|..|
  Rat   598 DVPSRHHPLEVTTGSHHHL-------------SPLPTAESTR--DGLG----------PGLLSPM 637

  Fly   721 VNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEP 785
            |:                         ..||:....     :|.::::              ..|
  Rat   638 VS-------------------------PLKGLGPPP-----LPPASQS--------------QSP 658

  Fly   786 GTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQF-------------RRD 837
            |..:...||..|       |..|.|:......:....||:.. |||..|             .||
  Rat   659 GAQSFSTIPSKP-------TYPPFQSPPPPLPSPQGYQGSFH-SIQNCFPYADCYRTTEPAASRD 715

  Fly   838 SQNSTASTYYGSMQSRRSSQSSQVSS----------IPTMRPNPS 872
            .....|..:.....|..||.|:.:|:          .||::|.||
  Rat   716 GLVGDAHGFNPLRPSTYSSLSTPLSAPGYEALAETPCPTLQPQPS 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	11/17 (65%)
		SFP1	<513..603	CDD:227516	70/89 (79%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..560	CDD:463886	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	17/20 (85%)
Glis1	NP_001100173.2	C2H2 Zn finger	376..395	CDD:275368	7/18 (39%)
		C2H2 Zn finger	406..431	CDD:275368	13/24 (54%)
		COG5048	435..>514	CDD:227381	61/79 (77%)
		C2H2 Zn finger	439..461	CDD:275368	17/21 (81%)
		C2H2 Zn finger	469..491	CDD:275368	17/22 (77%)
		C2H2 Zn finger	499..521	CDD:275368	18/21 (86%)