DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Glis1

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006238623.1	Gene:	Glis1 / 298732	RGDID:	1308030	Length:	793	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	244/890 - (27%)
Similarity:	310/890 - (34%)	Gaps:	332/890 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 RGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRA-SISRKRALSSSPYSD 224
            ||.:.| |.|.|...|.:.|...        |||.|...||.|....|| .:.|.|  |...||.
  Rat    25 RGPAGL-EAHMAFRIAVSGGGCG--------DGNPRDLLPRLPVPPPRAHDLLRPR--SPRDYSV 78

  Fly   225 SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATAL---------NPMSHVHSTRLQQIQA 280
            |                    ..|....:|||||.|..:|         :|..|
  Rat    79 S--------------------KAGGGKVNGSYGHSSEKSLLDLDLAEGPSPSCH----------- 112

  Fly   281 HLLRASAGLLNPM-TPQQVAASGFSIGHMPTSASLRVNDVHPNLSD--------------SHIQI 330
                  .||..|. ||.       ..||.|....| ::..|||.|.              .||:.
  Rat   113 ------QGLFLPAGTPP-------PRGHPPVCERL-LHFPHPNRSPRPQATYANGSLPAAQHIKQ 163

  Fly   331 TTSPTVTKDVS---------QVPAAAFSLKNLD-DAREKKGPFKD--VVPEQPSSTSGGVAQVEA 383
            ...|.....||         :.|.:.....:|| ..|....|...  :|..:|.|:.|  .|.||
  Rat   164 EALPDYQAMVSAHTPLPTHCRAPLSMGLHSDLDFPGRGLTNPAPSCYLVGNEPISSLG--PQPEA 226

  Fly   384 ---------------DSASSQLSDRCYNNVVNNI-----------------TGIPGDV------- 409
                           ...||..|..|.::.:|.:                 ..:|||:
  Rat   227 HLPEGSLKRCCLLGLPPTSSASSSPCASSDINPVIHSSQTALVSCVNGLRSPPLPGDLGGPPKRS 291

  Fly   410 -------KVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGD-FIE---------------- 450
                   .|:|...|    ||:.:.:    |..:..  :|.||.| |.|
  Rat   292 RHGPGPGPVSSDGQE----GSLQLEA----CRKSGF--LKQEPMDEFSELFAPHQQGLPPPYPLP 346

  Fly   451 -----------------------TNCHWRSCRIEFITQDELVKHINNDHIQTNK-KAFVCRWEDC 491
                                   ..|.|..|...:..|:|||:||...||...| :.|.|.|..|
  Rat   347 QLPTGPSLGGLGLGLAGRMAAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGC 411

  Fly   492 TRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSK 556
            .|..|||.|:|.|::|||.|:||||:||.||||.||:|||||||.|||||||||||.|::|||.|
  Rat   412 VRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQK 476

  Fly   557 AFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKK-HKG----- 615
            ||||:||||||| |||.:.|||.|:.|||:||||||||||||||.....|....|| |.|
  Rat   477 AFSNSSDRAKHQ-RTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPEA 540

  Fly   616 ---------------LPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSES 665
                           .||..:..:..|..|    ||......|.|.....|...|..|||    .
  Rat   541 AVLSECLALQQLQASTPLPASRGKGSQTLS----QELLPGVYPGSVTPQNGLASGILSPS----H 597

  Fly   666 DISS----------SNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAM 720
            |:.|          |:|||             ||...||:..  ||..          |.:|..|
  Rat   598 DVPSRHHPLEVTTGSHHHL-------------SPLPTAESTR--DGLG----------PGLLSPM 637

  Fly   721 VNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEP 785
            |:                         ..||:....     :|.::::              ..|
  Rat   638 VS-------------------------PLKGLGPPP-----LPPASQS--------------QSP 658

  Fly   786 GTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQF-------------RRD 837
            |..:...||..|       |..|.|:......:....||:.. |||..|             .||
  Rat   659 GAQSFSTIPSKP-------TYPPFQSPPPPLPSPQGYQGSFH-SIQNCFPYADCYRTTEPAASRD 715

  Fly   838 SQNSTASTYYGSMQSRRSSQSSQVSS----------IPTMRPNPS 872
            .....|..:.....|..||.|:.:|:          .||::|.||
  Rat   716 GLVGDAHGFNPLRPSTYSSLSTPLSAPGYEALAETPCPTLQPQPS 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	17/26 (65%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	17/20 (85%)
Glis1	XP_006238623.1	C2H2 Zn finger	376..395	CDD:275368	7/18 (39%)
		C2H2 Zn finger	406..431	CDD:275368	13/24 (54%)
		COG5048	435..>514	CDD:227381	61/79 (77%)
		C2H2 Zn finger	439..461	CDD:275368	17/21 (81%)
		zf-H2C2_2	453..480	CDD:290200	21/26 (81%)
		C2H2 Zn finger	469..491	CDD:275368	17/22 (77%)
		C2H2 Zn finger	499..521	CDD:275368	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010