DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and GLI2

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_011509271.2	Gene:	GLI2 / 2736	HGNCID:	4318	Length:	1670	Species:	Homo sapiens

Alignment Length:	1807	Identity:	469/1807 - (25%)
Similarity:	665/1807 - (36%)	Gaps:	688/1807 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RAAAVAAAATVLPGSPCINQH-----H---PTDVSSSVTVPSIIPTGGTSDSIKTSIQPQICNEN 80
            |.||...||::.|....:.||     |   |.|:.
Human   117 RTAAPLGAASLRPPRTLVPQHLLPPFHAPLPIDMR------------------------------ 151

  Fly    81 TLLGNAGHQ---HNHQPQHVHNIN----VTGQP--HDF-------HPAYRIPGYMEQLYSLQRTN 129
                   ||   ::::|..||.::    ::|.|  .|.       |||.  ||           .
Human   152 -------HQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAG--PG-----------E 196

  Fly   130 SASSFHDPYVNCASAFHL-------------AGLGLGSAD----FLGSRGLSSL----------- 166
            |..:...||||.....:|             |..||..||    .|..|||..|
Human   197 SPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYY 261

  Fly   167 -------------GELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALS 218
                         |:|...:..||:|..|  .|:...||.: |..|||     :...:|||||||
Human   262 HQMTLVAGHPAPYGDLLMQSGGAASAPHL--HDYLNPVDVS-RFSSPR-----VTPRLSRKRALS 318

  Fly   219 SSPYSD-SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTRLQQIQAH 281
            .||.|| |.|:..|||.|||||...:|.||.||||||||||:||.||:| .:..|.
Human   319 ISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHP--------- 374

  Fly   282 LLRASAGLLNPMTPQQVAAS----GFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQ 342
                    :||:..||:.:.    |.:.||.|.                  .|..|||.   ::|
Human   375 --------INPVAYQQILSQQRGLGSAFGHTPP------------------LIQPSPTF---LAQ 410

  Fly   343 VPAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPG 407
            .|.|..|:              :..|.|.||:|..::..   :.:.|.|:...::.||.: .|..
Human   411 QPMALTSI--------------NATPTQLSSSSNCLSDT---NQNKQSSESAVSSTVNPV-AIHK 457

  Fly   408 DVKVNS----------------RLDEYINCGSISIPSNEYDCA----NADTTDIKDEPGDFI-ET 451
            ..||.:                ::..:.:|| .::|.::...|    :.|..|.|.|....| ||
Human   458 RSKVKTEPEGLRPASPLALTQGQVSGHGSCG-CALPLSQEQLADLKEDLDRDDCKQEAEVVIYET 521

  Fly   452 NCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKP 516
            ||||..|..|:.||::||.||||:||...||.|||||:.|||.:|||||||||||||||||||||
Human   522 NCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKP 586

  Fly   517 HKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICK 581
            ||||||||.||||||||||||||||||||||.||:.||:||||||||||||||||||||||||||
Human   587 HKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICK 651

  Fly   582 APGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSE 646
            .||||||||||||||||||||||.:.:..||.:    ||.:.|..       |.:.|.||...:|
Human   652 IPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR----NDVHLRTP-------LLKENGDSEAGTE 705

  Fly   647 DSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYS-----------PDDLAENLNLDD 700
            ..      |..|....|.|.......| |..::...|.|..|           |..|....|.|.
Human   706 PG------GPESTEASSTSQAVEDCLH-VRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDS 763

  Fly   701 GWN--------------CDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLAR-----QRFR-- 744
            |..              .||....||...:            :|.:.||..|.:     .||.
Human   764 GVEMPGTGPGSLGDLTALDDTPPGADTSAL------------AAPSAGGLQLRKHMTTMHRFEQL 816

  Fly   745 GRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNT---------T 800
            .:.:.|.:..|.......|.:..|                       |:|.||.:         :
Human   817 KKEKLKSLKDSCSWAGPTPHTRNT-----------------------KLPPLPGSGSILENFSGS 858

  Fly   801 IGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSS--------- 856
            .||.....|.|..  .:.:|..:.|:...:|.  ||||..||.|:.|  ..|||||
Human   859 GGGGPAGLLPNPR--LSELSASEVTMLSQLQE--RRDSSTSTVSSAY--TVSRRSSGISPYFSSR 917

  Fly   857 QSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRS---SQMSNGANCNSFT-------------S 905
            :||:.|.:...||:.:  |:|..|||||...||||   ||.|.|:...:.|             :
Human   918 RSSEASPLGAGRPHNA--SSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAA 980

  Fly   906 TSG-----LPVLNKESNKSLNACINKPNIGVQGVGIYNSSLP---PPPSSHLIATNLKRLQRKDS 962
            |.|     ||.|.:.|.::..|.::.|          ..:||   |.|..          .|:.|
Human   981 TGGPPPTPLPGLERMSLRTRLALLDAP----------ERTLPAGCPRPLG----------PRRGS 1025

  Fly   963 EYHNFTSGRF-SVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTNISRFSTT 1026
            :...:..|.. :.|::.|                :|....|||.:|||...:...|..:.||.:|
Human  1026 DGPTYGHGHAGAAPAFPH----------------EAPGGGARRASDPVRRPDALSLPRVQRFHST 1074

  Fly  1027 PHSFDINVG--------KTNNIASSINKD-NLRKDLFT---------VSIKADMAMTSDQHPNER 1073
               .::|.|        :...:.|..:.| .|.:..::         |:::|..|......|...
Human  1075 ---HNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEAD 1136

  Fly  1074 INLDEVEELILPDEMLQYL--------------------------------------NLVKDDTN 1100
            :.|.| ::|:|||:::||:                                      .:|..|:|
Human  1137 LGLPE-DDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSN 1200

  Fly  1101 -------------------HLEKEHQAV---PVGSNVSETIASNHYR---EQSNIY--------- 1131
                               .|.|.:..|   .|.|...:.:||....   .|.|:.
Human  1201 VGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFG 1265

  Fly  1132 ----YTNKQILTPPSNVD-----IQPN-----------------------------TTKFT---- 1154
                |:.:.:...|..:|     :||.                             ||..:
Human  1266 QYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHAC 1330

  Fly  1155 ---VQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKCESFHHQSQKYMNTD---IGSKQQ------ 1207
               |..:.:.:.:.|:.:|...|...:|.:.||     ..|..|..:..|   :|::.:
Human  1331 YGQVHPQLSPSTISGALNQFPQSCSNMPAKPGH-----LGHPQQTEVAPDPTTMGNRHRELGVPD 1390

  Fly  1208 SAL---PSAHQRQT------------EKSNYNQI------------------------------- 1226
            |||   |..|..|:            .:..|:|:
Human  1391 SALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQP 1455

  Fly  1227 ---------------------------IDSSMTSLPEL-------------NVDSIYPRNETE-- 1249
                                       ...:|.::|..             |:.|:.|:...:
Human  1456 RPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDA 1520

  Fly  1250 ---------------NIFKVHGDHDNEIQCGIIS-------------QSQMSPSTNLNNDGQFST 1286
                           ::::..|..:|...|.::.             |.|..||..:|...  ||
Human  1521 GGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVS--ST 1583

  Fly  1287 VNMQPITTSKLFPPEPQKIVCD-------TQASNTSVMHLDTYQRTLEYVQSCQNWMETNNTSTN 1344
            |:.|.:...::   :...|:.|       :.|.:.|::|                       |.:
Human  1584 VDSQLLEAPQI---DFDAIMDDGDHSSLFSGALSPSLLH-----------------------SLS 1622

  Fly  1345 QIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMTTSLTSLLEENRYLQMM 1396
            |..|....|.|:...|.:     |...:||.:.||::.||||.||:::|.||
Human  1623 QNSSRLTTPRNSLTLPSI-----PAGISNMAVGDMSSMLTSLAEESKFLNMM 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	25/26 (96%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:290200	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
GLI2	XP_011509271.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I6202
eggNOG	1	0.900	-	-		E33208_3BFAM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1749
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003548
OrthoInspector	1	1.000	-	-		otm40412
orthoMCL	1	0.900	-	-		OOG6_104319
Panther	1	1.100	-	-	O	PTHR45718
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	1	1.000	-	-		X2040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.940