DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Glis1

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006503035.1	Gene:	Glis1 / 230587	MGIID:	2386723	Length:	804	Species:	Mus musculus

Alignment Length:	690	Identity:	211/690 - (30%)
Similarity:	280/690 - (40%)	Gaps:	173/690 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYVNCASAFHLAGLG-LGSADFLGSRGLSSLG 167
            |.|.|..|  |:|....:.:.|.|..|...:              |:. .||....||.|.||..
Mouse    63 GNPLDLLP--RLPVPPPRAHDLLRPRSPRDY--------------GVSKTGSGKVNGSYGHSSEK 111

  Fly   168 ELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMI 232
            .|.:..:|...:.|.....|       ...|:|.|.|   ...:..|  |...|:.:.
Mouse   112 SLLDLDLAEGPSPSCHQGLF-------LPAGTPPPRG---HPPVCEK--LLHFPHPNR------- 157

  Fly   233 RFSPNSLATIMNGSRGSSAASGSYGHISATAL----------NPM-SHVHSTRLQQIQAHLLRAS 286
              ||...||.:|||..::.      ||...||          .|: :|..:.....:.:.|....
Mouse   158 --SPRPQATFVNGSLPAAQ------HIKQEALPDYQAMVSAHTPLPTHCRAPSSMGLPSDLDFPD 214

  Fly   287 AGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHI-----------------QITTSP 334
            .||.||      |.|.:.:|:.|      ::|:.|. .::|:                 ..::||
Mouse   215 RGLTNP------APSCYLLGNEP------ISDLGPQ-PEAHLPEGSLKRCCLLGLPPTSSASSSP 266

  Fly   335 TVTKDVSQV--------PAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSG--GVAQVEADSASSQ 389
            ..:.|::.|        .:....|::.....:..||.|...| .|:|:.|  |..|:||...|..
Mouse   267 CASSDINPVIHSSQTALVSCVNGLRSPPLPGDLGGPPKRSRP-GPASSDGQEGSLQLEACRKSGF 330

  Fly   390 LS----DRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIE 450
            |.    |........:..|:|....: .:|......|.:.:.......|....
Mouse   331 LKQEPMDEFSELFAPHHQGLPPPYPL-PQLPTGPGLGGLGLGLAGRMVAGRQA------------ 382

  Fly   451 TNCHWRSCRIEFITQDELVKHINNDHIQTNK-KAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGE 514
              |.|..|...:..|:|||:||...||...| :.|.|.|..|.|..|||.|:|.|::|||.|:||
Mouse   383 --CRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGE 445

  Fly   515 KPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYI 579
            ||:||.||||.||:|||||||.|||||||||||.|::|||.|||||:||||||| |||.:.|||.
Mouse   446 KPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQ-RTHLDTKPYA 509

  Fly   580 CKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKK-HKGL-PLNDANSR---LQQ------------ 627
            |:.|||:||||||||||||||.....|....|| |.|. |..|..|.   |||
Mouse   510 CQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGADPEADVLSECLSLQQLQASTLLPASRG 574

  Fly   628 NNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISS----------SNHHLVNGVRASD 682
            ..|:...||......|.|.....|...|..|||    .|:.|          |:|||
Mouse   575 KGSQTLSQELLPGVYPGSVTPQNGLASGILSPS----HDVPSRHHPLEVPTGSHHHL-------- 627

  Fly   683 SLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVN 722
                 ||...||:..  ||..          |.:|..||:
Mouse   628 -----SPLPTAESTR--DGLG----------PSLLSPMVS 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	17/26 (65%)
		C2H2 Zn finger	519..541	CDD:275368	17/21 (81%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	17/20 (85%)
Glis1	XP_006503035.1	C2H2 Zn finger	387..406	CDD:275368	7/18 (39%)
		C2H2 Zn finger	417..442	CDD:275368	13/24 (54%)
		COG5048	446..>525	CDD:227381	61/79 (77%)
		C2H2 Zn finger	450..472	CDD:275368	17/21 (81%)
		C2H2 Zn finger	480..502	CDD:275368	17/22 (77%)
		C2H2 Zn finger	510..532	CDD:275368	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010