DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Glis3

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_780668.3	Gene:	Glis3 / 226075	MGIID:	2444289	Length:	935	Species:	Mus musculus

Alignment Length:	777	Identity:	225/777 - (28%)
Similarity:	306/777 - (39%)	Gaps:	223/777 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALPTYFPLAYSELQFLASRR-------AAAVAAAATVLP-----GSP------------------ 39
            |.|.:.|......|.||:.:       |..:||..|:.|     |.|
Mouse    76 ASPIHLPALSPRRQLLANGKPQFQVTPAGVMAAPHTIKPKQQEFGDPFSPNPEKGALGFGPQCKS 140

  Fly    40 -----CINQHHPTDVSSSVTVPSIIPTGGTSDSIKTS---IQPQICNENTLLGNAGHQHNHQPQH 96
                 |.|.   ...||.:.|..:.|....:..:.|:   |.|.:                 |:.
Mouse   141 IGKGSCNNL---VVTSSPMMVQRLGPISPPASQVSTACKQISPSL-----------------PRA 185

  Fly    97 VHNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSR 161
            |:..|:...|.|..........:....||..:.||.|....:.....||.    .|.|:.  .|:
Mouse   186 VNAANLNRPPSDTRSVILQESLVSTTLSLTESQSALSVKQEWSQSYRAFP----SLSSSH--SSQ 244

  Fly   162 GLSSLGELHNAAVAAAAAGSLASTD---FHFSVDGNRR-LGSPRPPGGSIRASISRKRALSSSPY 222
            ..:.||:|.:.......:|:..|..   :.|.::.:.. ..|||.......::.|:|||||.||.
Mouse   245 NGTDLGDLLSLPPGTPVSGNSVSNSLPPYLFGMENSHSPYPSPRHSATRAHSTRSKKRALSLSPL 309

  Fly   223 SD--SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRA 285
            ||  ..|.|::||.||.||...:||.|.|.|           .|:|.|.|:        .|.|
Mouse   310 SDGIGIDFNTIIRTSPTSLVAYINGPRASPA-----------NLSPQSEVY--------GHFL-- 353

  Fly   286 SAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSL 350
              |:.....||..|.:....|.:..|.             .|    |.|...:|.:   .....:
Mouse   354 --GVRGSCIPQSCAVASGQKGILVASG-------------GH----TLPGYGEDGT---LEYERM 396

  Fly   351 KNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNIT---GIPG----- 407
            :.|:....:.||                                    |||:.   |:||
Mouse   397 QQLEHGGLQPGP------------------------------------VNNMVLQPGLPGQDGQT 425

  Fly   408 -DVKVNSRLDEYINCGSISIPSNEYDCANA----------------------------DTTDIK- 442
             ::....||:|:        |::..|..:|                            .|..:.
Mouse   426 ANMLKTERLEEF--------PASALDLPSALPLPLPPPQGPPPPYHAHPHLHHPELLPHTQSLSL 482

  Fly   443 -----DEPGDFIETN----CHWRSCRIEFITQDELVKHINNDHIQTNK-KAFVCRWEDCTRGEKP 497
                 :|.|:..::.    |.|..|...:..|:|||:||...||...| :.|.|.|..|.|..||
Mouse   483 AQTGLEEDGEMEDSGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKP 547

  Fly   498 FKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNAS 562
            |.|:|.|::|||.|:||||:|||||||.||:|||||||.|||||||||||.|::|||.|||||:|
Mouse   548 FNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSS 612

  Fly   563 DRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKK-------HKGLPLND 620
            |||||| |||.:.|||.|:.||||||||||||||||||.....|..|.||       |..| |.|
Mouse   613 DRAKHQ-RTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARKKLRSSTELHPDL-LTD 675

  Fly   621 --ANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRA 680
              |...||...|..:..:|.:..||       |...|....:....:.|.:|||...:|..|
Mouse   676 CLAVQPLQPATSPGDAADHTVGHSP-------GPGPGPGPGAELYSAPIFASNHSTRSGTAA 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	18/26 (69%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	18/20 (90%)
Glis3	NP_780668.3	C2H2 Zn finger	506..525	CDD:275368	7/18 (39%)
		C2H2 Zn finger	536..561	CDD:275368	13/24 (54%)
		SFP1	<558..652	CDD:227516	75/94 (80%)
		C2H2 Zn finger	569..591	CDD:275368	18/21 (86%)
		C2H2 Zn finger	599..621	CDD:275368	17/22 (77%)
		PHA03247	<612..861	CDD:223021	55/128 (43%)
		C2H2 Zn finger	629..651	CDD:275368	19/21 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040