DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and GLIS3

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001035878.1	Gene:	GLIS3 / 169792	HGNCID:	28510	Length:	930	Species:	Homo sapiens

Alignment Length:	833	Identity:	219/833 - (26%)
Similarity:	307/833 - (36%)	Gaps:	264/833 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PG-SPCINQHHPTDVSSSVTVPSIIPTGG-------TSDS------------IKTSIQPQICNEN 80
            || |||.:...||..|.:..:...:|:||       .::|            :.|:.:|:.  :.
Human    38 PGPSPCGSTSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQMLTNGKPRF--QV 100

  Fly    81 TLLGNAGHQHNHQPQH-----------------------------VHNINVTGQPHDFH------ 110
            |..|.....|..:|:.                             .:|:.||..|....
Human   101 TQAGGMSGSHTLKPKQQEFGSPFPPNPGKGALGFGPQCKSIGKGSCNNLVVTSSPMMVQRLGLIS 165

  Fly   111 -PAYRIPGYMEQLY-SLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSS-------- 165
             ||.::.....|:. ||||..:|::.:.|..:..|......|...:.....|:..||
Human   166 PPASQVSTACNQISPSLQRAMNAANLNIPPSDTRSLISRESLASTTLSLTESQSASSMKQEWSQG 230

  Fly   166 -----------------LGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRP-PGGS---IRA 209
                             ||:|.:.....:.:.:..|......:.|.....||.| |..|   ..:
Human   231 YRALPSLSNHGSQNGLDLGDLLSLPPGTSMSSNSVSNSLPSYLFGTESSHSPYPSPRHSSTRSHS 295

  Fly   210 SISRKRALSSSPYSD--SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHS 272
            :.|:|||||.||.||  ..|.|::||.||.||...:||||.|.|           .|:|...|:
Human   296 ARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGSRASPA-----------NLSPQPEVY- 348

  Fly   273 TRLQQIQAHLLRASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVT 337
                   .|.|    |:.....||.....|...|.:.....|.:                 |...
Human   349 -------GHFL----GVRGSCIPQPRPVPGSQKGVLVAPGGLAL-----------------PAYG 385

  Fly   338 KDVSQVPAAAFS---LKNLDDAREKKGPFKDVVPEQ----PSSTSGGVAQVEADSASSQLSDRCY 395
            :|      .|..   ::.|:....:.|....:|.:.    |.|.|.|:.:.|
Human   386 ED------GALEHERMQQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTE------------- 431

  Fly   396 NNVVNNITGIPGDVKVNSRLDEYINCGSISIP--------------------------------S 428
                              ||:|:.. .::.:|                                :
Human   432 ------------------RLEEFPG-STVDLPPAPPLPPLPPPPGPPPPYHAHAHLHHPELGPHA 477

  Fly   429 NEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNK-KAFVCRWEDCT 492
            .:.....|...|..:..|...:..|.|..|...:..|:|||:||...||...| :.|.|.|..|.
Human   478 QQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWAGCP 542

  Fly   493 RGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKA 557
            |..|||.|:|.|::|||.|:||||:|||||||.||:|||||||.|||||||||||.|::|||.||
Human   543 RRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKA 607

  Fly   558 FSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKK-------HKG 615
            |||:||||||| |||.:.|||.|:.||||||||||||||||||.....|..|.||       |..
Human   608 FSNSSDRAKHQ-RTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPD 671

  Fly   616 L--------------------------------------PLNDANSRLQQNNS----------RH 632
            |                                      |:..:|...:...:          .|
Human   672 LLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSH 736

  Fly   633 NLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLL 685
            ....||:..||.:..|.|..:....:.:.:......|.:|.....|.|..|:|
Human   737 PSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSIL 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	18/26 (69%)
		C2H2 Zn finger	519..541	CDD:275368	18/21 (86%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	18/20 (90%)
GLIS3	NP_001035878.1	zf-H2C2_2	554..580	CDD:290200	18/25 (72%)
		C2H2 Zn finger	569..591	CDD:275368	18/21 (86%)
		zf-H2C2_2	583..610	CDD:290200	21/26 (81%)
		C2H2 Zn finger	599..621	CDD:275368	17/22 (77%)
		C2H2 Zn finger	629..651	CDD:275368	19/21 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040