DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ci and ZXDB

DIOPT Version :10

Sequence 1:NP_524617.3 Gene:ci / 43767 FlyBaseID:FBgn0004859 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_009088.1 Gene:ZXDB / 158586 HGNCID:13199 Length:803 Species:Homo sapiens


Alignment Length:688 Identity:138/688 - (20%)
Similarity:226/688 - (32%) Gaps:224/688 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 SRGSSAASGSYGHISA-----TALNPMSHVHST--RLQQIQAHLLRASAGLLNPMTPQQVAASGF 303
            :.|.:||.|..|.:.:     ..|.|.:....|  :..|::.|||..|:                
Human   249 AEGPAAALGPRGPLGSGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSS---------------- 297

  Fly   304 SIGHMP-------------TSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDD 355
            |.|..|             ||..|:.:      ..||.::.......:...:.....::||....
Human   298 SQGQRPFKCPLGGCGWTFTTSYKLKRH------LQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMK 356

  Fly   356 AREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYIN 420
            ..|::..||..|.|:                                 ..|...|:::....:..
Human   357 GHEQENSFKCEVCEE---------------------------------SFPTQAKLSAHQRSHFE 388

  Fly   421 CGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFV 485
                  |...|.||                    :..|:..|||...|..| |..|.: .::.|.
Human   389 ------PERPYQCA--------------------FSGCKKTFITVSALFSH-NRAHFR-EQELFS 425

  Fly   486 CRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCE 550
            |.:..|:   |.:.....|.:|:|.||||:|..|.|:||...::.:..|..|.|.|..::.:.|.
Human   426 CSFPGCS---KQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCP 487

  Fly   551 YPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKH-- 613
            ..||.|:|:.| :..|..:.||...||::|...||..|::..|||..|           :|||  
Human   488 VEGCGKSFTRA-EHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIH-----------SKKHLQ 540

  Fly   614 ------KGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNH 672
                  ...|::..|...   .|:|:::.|.:......:|. |.::                   
Human   541 DVDTWKSRCPISSCNKLF---TSKHSMKTHMVKRHKVGQDL-LAQL------------------- 582

  Fly   673 HLVNGVRASDSLLTYSPDDL--AENLNLDDGWNCDDDVDVADLPIVLRAMVNIG----NGNASAS 731
            ...|.:..|..|.:...:||  ||.::|     ..|..|.....::..|:||.|    :..:.:|
Human   583 EAANSLTPSSELTSQRQNDLSDAEIVSL-----FSDVPDSTSAALLDTALVNSGILTIDVASVSS 642

  Fly   732 TIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKL 796
            |:.|                         ::|.:|        |..:.:....|...|       
Human   643 TLAG-------------------------HLPANN--------NNSVGQAVDPPSLMA------- 667

  Fly   797 PNTTIGGYTEDPLQN-QTS-FRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSS 859
                    |.||.|: .|| |..|.:      :|..|.....|..:|.:....||:.|.....||
Human   668 --------TSDPPQSLDTSLFFGTAA------TGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSS 718

  Fly   860 QVSSIPTMRPNPSCNSTASFYDPISPG---CSRRSSQM 894
            ......|    ||...|.. .|.::|.   |....|::
Human   719 PEPQALT----PSSKLTVD-TDALTPSSTLCENSVSEL 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ciNP_524617.3 zf-H2C2_2 503..>521 CDD:463886 9/17 (53%)
SFP1 <513..603 CDD:227516 30/89 (34%)
C2H2 Zn finger 519..541 CDD:275368 7/21 (33%)
zf-H2C2_2 533..560 CDD:463886 9/26 (35%)
C2H2 Zn finger 549..572 CDD:275368 7/22 (32%)
C2H2 Zn finger 580..601 CDD:275368 8/20 (40%)
ZXDBNP_009088.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..260 4/10 (40%)
Required for interaction with ZXDC. /evidence=ECO:0000250 271..577 84/406 (21%)
C2H2 Zn finger 273..295 CDD:275368 6/21 (29%)
zf-C2H2 304..328 CDD:395048 3/29 (10%)
C2H2 Zn finger 306..328 CDD:275368 3/27 (11%)
C2H2 Zn finger 336..358 CDD:275368 2/21 (10%)
COG5048 <344..539 CDD:227381 62/270 (23%)
C2H2 Zn finger 366..386 CDD:275368 4/52 (8%)
C2H2 Zn finger 395..417 CDD:275368 9/42 (21%)
C2H2 Zn finger 429..448 CDD:275368 5/21 (24%)
C2H2 Zn finger 456..478 CDD:275368 7/21 (33%)
COG5048 466..>747 CDD:227381 79/379 (21%)
C2H2 Zn finger 486..508 CDD:275368 7/22 (32%)
C2H2 Zn finger 516..538 CDD:275370 9/32 (28%)
Required for transcriptional activation. /evidence=ECO:0000250 576..703 36/205 (18%)
Blue background indicates that the domain is not in the aligned region.

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