DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ci and ZXDB

DIOPT Version :9

Sequence 1:NP_524617.3 Gene:ci / 43767 FlyBaseID:FBgn0004859 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_009088.1 Gene:ZXDB / 158586 HGNCID:13199 Length:803 Species:Homo sapiens


Alignment Length:688 Identity:138/688 - (20%)
Similarity:226/688 - (32%) Gaps:224/688 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 SRGSSAASGSYGHISA-----TALNPMSHVHST--RLQQIQAHLLRASAGLLNPMTPQQVAASGF 303
            :.|.:||.|..|.:.:     ..|.|.:....|  :..|::.|||..|:                
Human   249 AEGPAAALGPRGPLGSGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSS---------------- 297

  Fly   304 SIGHMP-------------TSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDD 355
            |.|..|             ||..|:.:      ..||.::.......:...:.....::||....
Human   298 SQGQRPFKCPLGGCGWTFTTSYKLKRH------LQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMK 356

  Fly   356 AREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYIN 420
            ..|::..||..|.|:                                 ..|...|:::....:..
Human   357 GHEQENSFKCEVCEE---------------------------------SFPTQAKLSAHQRSHFE 388

  Fly   421 CGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFV 485
                  |...|.||                    :..|:..|||...|..| |..|.: .::.|.
Human   389 ------PERPYQCA--------------------FSGCKKTFITVSALFSH-NRAHFR-EQELFS 425

  Fly   486 CRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCE 550
            |.:..|:   |.:.....|.:|:|.||||:|..|.|:||...::.:..|..|.|.|..::.:.|.
Human   426 CSFPGCS---KQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCP 487

  Fly   551 YPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKH-- 613
            ..||.|:|:.| :..|..:.||...||::|...||..|::..|||..|           :|||  
Human   488 VEGCGKSFTRA-EHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIH-----------SKKHLQ 540

  Fly   614 ------KGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNH 672
                  ...|::..|...   .|:|:::.|.:......:|. |.::                   
Human   541 DVDTWKSRCPISSCNKLF---TSKHSMKTHMVKRHKVGQDL-LAQL------------------- 582

  Fly   673 HLVNGVRASDSLLTYSPDDL--AENLNLDDGWNCDDDVDVADLPIVLRAMVNIG----NGNASAS 731
            ...|.:..|..|.:...:||  ||.::|     ..|..|.....::..|:||.|    :..:.:|
Human   583 EAANSLTPSSELTSQRQNDLSDAEIVSL-----FSDVPDSTSAALLDTALVNSGILTIDVASVSS 642

  Fly   732 TIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKL 796
            |:.|                         ::|.:|        |..:.:....|...|       
Human   643 TLAG-------------------------HLPANN--------NNSVGQAVDPPSLMA------- 667

  Fly   797 PNTTIGGYTEDPLQN-QTS-FRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSSQSS 859
                    |.||.|: .|| |..|.:      :|..|.....|..:|.:....||:.|.....||
Human   668 --------TSDPPQSLDTSLFFGTAA------TGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSS 718

  Fly   860 QVSSIPTMRPNPSCNSTASFYDPISPG---CSRRSSQM 894
            ......|    ||...|.. .|.::|.   |....|::
Human   719 PEPQALT----PSSKLTVD-TDALTPSSTLCENSVSEL 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ciNP_524617.3 zf-H2C2_2 503..530 CDD:290200 12/26 (46%)
C2H2 Zn finger 519..541 CDD:275368 7/21 (33%)
zf-H2C2_2 533..560 CDD:290200 9/26 (35%)
C2H2 Zn finger 549..572 CDD:275368 7/22 (32%)
C2H2 Zn finger 580..601 CDD:275368 8/20 (40%)
ZXDBNP_009088.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..260 4/10 (40%)
Required for interaction with ZXDC. /evidence=ECO:0000250 271..577 84/406 (21%)
C2H2 Zn finger 273..295 CDD:275368 6/21 (29%)
zf-C2H2_aberr 304..449 CDD:293622 33/214 (15%)
zf-C2H2 304..328 CDD:278523 3/29 (10%)
C2H2 Zn finger 306..328 CDD:275368 3/27 (11%)
C2H2 Zn finger 336..358 CDD:275368 2/21 (10%)
zf-H2C2_2 350..373 CDD:290200 7/55 (13%)
zf-C2H2 364..386 CDD:278523 6/54 (11%)
C2H2 Zn finger 366..386 CDD:275368 4/52 (8%)
C2H2 Zn finger 395..417 CDD:275368 9/42 (21%)
C2H2 Zn finger 429..448 CDD:275368 5/21 (24%)
COG5048 <441..572 CDD:227381 43/145 (30%)
C2H2 Zn finger 456..478 CDD:275368 7/21 (33%)
zf-H2C2_2 471..497 CDD:290200 9/25 (36%)
C2H2 Zn finger 486..508 CDD:275368 7/22 (32%)
C2H2 Zn finger 516..538 CDD:275370 9/32 (28%)
Required for transcriptional activation. /evidence=ECO:0000250 576..703 36/205 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157352
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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