Protein Alignment ci and GLIS1

DIOPT Version :9

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001377765.1
• Gene: GLIS1 / 148979
• HGNCID: 29525
• Length: 803
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 203/714 - (28%)
• Similarity: 269/714 - (37%)
• Gaps: 244/714 - (34%)

  Fly    94 PQHVHNINVTGQPHDFHPA-------------YRIPGYMEQLYSLQRTNS------------ASS 133
            |...|::.....|.|:.|:             :|.||..:.|..|.....            |.|
Human    61 PPRAHDLLRPRSPRDYGPSKAAAAGKVNGSYGHRTPGSEKSLLDLDLAEGPGPTCCQGLFLPAGS 125

  Fly   134 -------------FHDPYVNCA---SAFHLAGLGLGSADFLGSRGLSSLGELHNA--AVAAAAAG 180
                         .|.|:.:.:   .|.::.| .|.:...:....|.....:..|  :::|...|
Human   126 PPPRAHPQACERLLHFPHPDRSPRPQATYVNG-SLPTTQHIKQESLPDYQAMAEARTSLSAHCRG 189

  Fly   181 SLASTDFHFSVD-GNRRLGSPRP---------------------PGGSIR----ASISRKRALSS 219
            .|| |..|..:| ..|.|.:|.|                     |.||::    ..:......||
Human   190 PLA-TGLHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASS 253

  Fly   220 SPYSDSFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLR 284
            ||.:.| |:.|:||.|..||.|.:||.| |...:|..|
Human   254 SPCASS-DVTSIIRSSQTSLVTCVNGLR-SPPLTGDLG--------------------------- 289

  Fly   285 ASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSH---IQITTSPTVTKDVSQVPAA 346
                     .|.:.|..|                  |..:|||   :|:......: .:.|.||.
Human   290 ---------GPSKRARPG------------------PASTDSHEGSLQLEACRKAS-FLKQEPAD 326

  Fly   347 AFSLKNLDDAREKKGPFKDVVPE-------QPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITG 404
            .||        |..||.:..:|.       .|..:.||:.                       .|
Human   327 EFS--------ELFGPHQQGLPPPYPLSQLPPGPSLGGLG-----------------------LG 360

  Fly   405 IPGDVKVNSRLDEYINCGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELV 469
            :.|.|....:.                                     |.|..|...:..|:|||
Human   361 LAGRVVAGRQA-------------------------------------CRWVDCCAAYEQQEELV 388

  Fly   470 KHINNDHIQTNK-KAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKC--------TFEGCF 525
            :||...||...| :.|.|.|..|.|..|||.|:|.|::|||.|:||||:||        .||||.
Human   389 RHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMPFPQFFHEFEGCS 453

  Fly   526 KAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYT 590
            ||:|||||||.|||||||||||.|::|||.|||||:||||||| |||.:.|||.|:.|||:||||
Human   454 KAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQ-RTHLDTKPYACQIPGCSKRYT 517

  Fly   591 DPSSLRKHVKTVHGAEFYANKK-HKGLPLNDANSR-----LQQNNSRHNL------------QEH 637
            ||||||||||.....|....|| |.| |..:|:..     |||.::...|            ||.
Human   518 DPSSLRKHVKAHSAKEQQVRKKLHAG-PDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQEL 581

  Fly   638 NIDSSPCSEDSHLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDG 701
            .....|.|...|.|...|...|:    .|: .|.||.::...:|...|  ||..:||:..  ||
Human   582 LPGVYPGSITPHNGLASGLLPPA----HDV-PSRHHPLDATTSSHHHL--SPLPMAESTR--DG 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	17/34 (50%)
		C2H2 Zn finger	519..541	CDD:275368	17/29 (59%)
		zf-H2C2_2	533..560	CDD:290200	21/26 (81%)
		C2H2 Zn finger	549..572	CDD:275368	17/22 (77%)
		C2H2 Zn finger	580..601	CDD:275368	17/20 (85%)
GLIS1	NP_001377765.1	C2H2 Zn finger	376..395	CDD:275368	7/18 (39%)
		C2H2 Zn finger	406..431	CDD:275368	13/24 (54%)
		COG5048	447..>522	CDD:227381	57/75 (76%)
		C2H2 Zn finger	450..469	CDD:275368	15/18 (83%)
		C2H2 Zn finger	477..499	CDD:275368	17/22 (77%)
		C2H2 Zn finger	507..529	CDD:275368	18/21 (86%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040