DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and Gli2

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_036016415.1	Gene:	Gli2 / 14633	MGIID:	95728	Length:	1581	Species:	Mus musculus

Alignment Length:	1774	Identity:	488/1774 - (27%)
Similarity:	684/1774 - (38%)	Gaps:	633/1774 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAAVAAAA-------------TVLPGSPCINQHHPTDVSS--SVTVP-SIIPTGGTSDSIKTSIQ 73
            ||||||..             ||....|.:.:..|....|  :|||| .::|.......|
Mouse    38 AAAVAAHGGNASCVKLTIINRTVRDPVPRVERDRPGHPISPLTVTVPQQLLPAFHAPLPI----- 97

  Fly    74 PQICNENTLLGNAGHQ---HNHQPQHVHNIN----VTGQP--HDF-------HPAYRIPGYMEQL 122
                       :..||   :::.|..||:::    ::|.|  .|.       |||.  ||
Mouse    98 -----------DMRHQEGRYHYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAG--PG----- 144

  Fly   123 YSLQRTNSASSFHDPYVNCASAFHL-------------AGLGLGSAD----FLGSRGLSSL---- 166
                  .|..|.|.||||.....:|             |..||..||    .|..|||.||
Mouse   145 ------ESPFSAHHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPG 203

  Fly   167 --------------------GELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASI 211
                                |:|...:..||:|..|  .|:...||.: |..|||     :...:
Mouse   204 TNPSDYYHQMTLMASHPTPYGDLLMQSGGAASAPHL--HDYLNPVDAS-RFSSPR-----VTPRL 260

  Fly   212 SRKRALSSSPYSD-SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP-MSHVHSTR 274
            |||||||.||.|| |.|:..|||.|||||...:|.||.||||||||||:||.||:| .:..|.
Mouse   261 SRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHP-- 323

  Fly   275 LQQIQAHLLRASAGLLNPMTPQQVAAS----GFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPT 335
                           :||:..||:.:.    |.:.||.|           |.:..|...:...|.
Mouse   324 ---------------INPVAYQQILSQQRGLGSAFGHTP-----------PLIQPSPTFLAQQPM 362

  Fly   336 VTKDVSQVPA--AAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNV 398
            ....:|.:|.  ::.|...|:||.:.|                            |.|:...::.
Mouse   363 TLTSISTMPTQLSSSSSNCLNDANQNK----------------------------QNSESAVSST 399

  Fly   399 VNNITGIPGDVKVNSRLDEYINCGSISIPSNEY-DC-ANADTTDIKDEPGDFI-ETNCHWRSCRI 460
            ||.|| |....||.:..:.......:.:...:. |. .:.|..|.|.|....| ||||||..|..
Mouse   400 VNPIT-IHKRSKVKTEAEGLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTK 463

  Fly   461 EFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCF 525
            |:.||::||.||||:||...||.|||||:.|||.:|||||||||||||||||||||||||||||.
Mouse   464 EYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCS 528

  Fly   526 KAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYT 590
            ||||||||||||||||||||||.||:.||:||||||||||||||||||||||||||.||||||||
Mouse   529 KAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYT 593

  Fly   591 DPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSR---LQQNNSRH-------NLQEHNIDSSPCS 645
            ||||||||||||||.:.:..||.:    ||.:.|   |::|....       ...|.::::|..|
Mouse   594 DPSSLRKHVKTVHGPDAHVTKKQR----NDVHVRAPLLKENGDNEASAEPGGRGPEESVEASSTS 654

  Fly   646 ---EDS-HLGKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDD 706
               ||. |:        .:||:||.      .|......:.|..:..|..|....|.|.|
Mouse   655 HTVEDCLHI--------KAIKTESS------GLCQSSPGAQSSCSSEPSPLGSAPNNDSG----- 700

  Fly   707 DVDVADLPIVLRAMVNIGNGNASASTIGG---SVLARQRFRGRLQTKGINSSTIMLCNIPESNRT 768
                .::|..  ...::|:..|.|.|..|   |.||... .|.||.:. :.||:
Mouse   701 ----MEMPGT--GPGSLGDLTALADTCPGADTSALAAPS-TGGLQLRK-HMSTV----------- 746

  Fly   769 FGISELNQRITELKME---------------PGTDAEIKIPKLP---------NTTIGGYTEDPL 809
                   .|..:||.|               |.| ...|:|.||         |.|.||.....|
Mouse   747 -------HRFEQLKREKLKSLKDSCSWAGPAPHT-RNTKLPPLPVNGSVLENFNNTGGGGPAGLL 803

  Fly   810 QNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGSMQSRRSS---------QSSQVSSIP 865
            .:|.....|      .|:...|.|.||||..||.|:.|  ..|||||         :||:.|.:.
Mouse   804 PSQRLPELT------EVTMLSQLQERRDSSTSTMSSAY--TVSRRSSGISPYFSSRRSSEASPLG 860

  Fly   866 TMRPNPSCNSTASFYDPISPGCSRRSSQMS----NGANCNSFT-------------STSG----- 908
            .:||:.:  |:|..|||||...|||||:.|    .|....:.|             :|.|
Mouse   861 GLRPHNA--SSADSYDPISTDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYAAATGGPPPTP 923

  Fly   909 LPVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRKDSEYHNFTSGR-- 971
            ||.|::.|.::..|.::.|...:.|      :.|.|..           .|:.|:...::.|.
Mouse   924 LPGLDRVSLRTRLALLDAPERALPG------ACPHPLG-----------PRRGSDGPTYSHGHGH 971

  Fly   972 ---FSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPV--PNINLDP--LTNISRFSTTPH- 1028
               .:.|::.|.         |.|       |:.||.:|||  |    ||  |..:.||.:|.:
Mouse   972 GYAGAAPAFPHE---------GPN-------SSTRRASDPVRRP----DPLILPRVQRFHSTHNM 1016

  Fly  1029 --------------------SFDINVGKTNNIAS----SINKDNLRKDLFTVSI-----KADMAM 1064
                                |.|.|:  |.|..|    ||| :|:..:.....:     :.|:.:
Mouse  1017 NPGSLPPCADRRGLHVQSHPSVDSNL--TRNAYSPRPPSIN-ENVVMEAVAAGVDGPGLECDLGL 1078

  Fly  1065 TSDQHPNERINLDEVEELILPDEMLQYLNL----VKDD--TNHLEKEHQAVPVGSNVSETIASNH 1123
            ..|             ||:|||:::||:..    ..||  ......|....|..|.:.......|
Mouse  1079 VED-------------ELVLPDDVVQYIKAHTGGTLDDGIRQGYPTEGTGFPENSKLPSPGLQGH 1130

  Fly  1124 -----------------------YREQSNIYYTN-----------------KQILTPP---SNVD 1145
                                   |...||:..:|                 .|:..||   ||:.
Mouse  1131 RRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTVDALPTQVKPPPFPHSNLA 1195

  Fly  1146 I---QP--------------------NTTKFTVQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKC 1187
            :   :|                    ::|:..:|.:.|.:|..||::|:.....|      .::|
Mouse  1196 VVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLRGAPSASRGSYTQQPRQPAA------GSQC 1254

  Fly  1188 ---------ESFHHQSQKYMNTDIGS-----------------------KQQSALPSA-----HQ 1215
                     ::.:.|:...::.:|.|                       :|...:|:|     ||
Mouse  1255 LGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKPSHLGLPQQMEVVPNATIMNGHQ 1319

  Fly  1216 RQTEKSNYNQIIDSSMTSLPELNVDSIYPRNET----ENIFKVHGDHDNEIQCGIISQSQ----- 1271
            |:      :.:.:||:.::.:.:....||:.::    .|:...|       |.|.:...|
Mouse  1320 RE------HGVPNSSLAAVSQPHPVLSYPQQDSYQQGSNLLSSH-------QPGFMESQQNAGFG 1371

  Fly  1272 -------MSPSTNLNNDGQFS--------TVNMQPIT-----TSKLFP-----------PEPQKI 1305
                   :.|:|...:.|..|        |.....:|     |::..|           |:|.:.
Mouse  1372 LMQPRPPLEPNTASRHRGVRSGQQQLYARTTGQAMVTSANQETAEAMPKGPAGTMVSLAPQPSQD 1436

  Fly  1306 VCDTQASNT----SVMHL-------DTYQRTLEYVQSCQNWMETN---NTSTNQIQSL------- 1349
            ....|..||    ..:|:       ...|......|:|.:.::..   :...||:.|.
Mouse  1437 TGRAQDQNTLYYYGQIHMYEQNGGCPAVQPQPPQPQACSDSIQPEPLPSPGVNQVSSTVDSQLLE 1501

  Fly  1350 ------------------------PGM-------------PVNNTLFPDVSSSTHPYHGTNMVIN 1377
                                    |.:             |.|:...|.:     |...:||.:.
Mouse  1502 PPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSSRLTTPRNSLTLPSI-----PAGISNMAVG 1561

  Fly  1378 DMTTSLTSLLEENRYLQMM 1396
            ||::.||||.||:::|.||
Mouse  1562 DMSSMLTSLAEESKFLNMM 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	25/26 (96%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:290200	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
Gli2	XP_036016415.1	SFP1	<516..606	CDD:227516	83/89 (93%)
		C2H2 Zn finger	522..544	CDD:275368	20/21 (95%)
		COG5048	525..>695	CDD:227381	98/187 (52%)
		C2H2 Zn finger	552..575	CDD:275368	19/22 (86%)
		C2H2 Zn finger	583..604	CDD:275368	19/20 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6115
eggNOG	1	0.900	-	-		E33208_3BFAM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1620
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003548
OrthoInspector	1	1.000	-	-		otm42485
orthoMCL	1	0.900	-	-		OOG6_104319
Panther	1	1.100	-	-	O	PTHR45718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R588
SonicParanoid	1	1.000	-	-		X2040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850