Protein Alignment ci and Gli3

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_536330.2
• Gene: Gli3 / 140588
• RGDID: 620272
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 1684
• Identity: 474/1684 - (28%)
• Similarity: 654/1684 - (38%)
• Gaps: 576/1684 - (34%)

  Fly    38 SPCINQHHPTDVSSSVTVPS-----IIPTGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHV 97
            ||....|.|:.:|||.|.|.     |.|....:.:.::...|
  Rat   151 SPIPPLHVPSALSSSPTYPDLPFIRISPHRNPTAASESPFSP----------------------- 192

  Fly    98 HNINVTGQPHDFHPAYRIPGYMEQLYSLQRTNSASSF---------HDPY--VNCASAFHLAGLG 151
                    ||.:     |..||:.:.||..:.|.|..         ..|:  |:.|..:|...|.
  Rat   193 --------PHPY-----INPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYHQMALL 244

  Fly   152 LGS----ADFLGSRGLSSLGELHNAAVAAAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASIS 212
            .|.    ||.|.|...:..|.:|              .::..::| :.|..|||     :.|..|
  Rat   245 TGQRSPYADILPSAATAGAGAIH--------------MEYLHAMD-STRFPSPR-----LSARPS 289

  Fly   213 RKRALSSSPYSD-SFDINSMIRFSPNSLATIMNGSRGSSAASGSYGHISATALNP---------- 266
            |||.||.||.|| |||:.:|||.|||||.||:|.||.||:|||||||:||:|::|
  Rat   290 RKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAP 354

  Fly   267 -MSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAASGFSIGHMPTSASLRVNDVHPNLSDSHIQI 330
             ..|:|    |||              ::.||...|.|  ||.|..       :||        .
  Rat   355 VSLHMH----QQI--------------LSRQQSLGSAF--GHSPPL-------IHP--------A 384

  Fly   331 TTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCY 395
            .|.|| .:.:..:|..      |:..:...||.:.   .|...||        :||.|...|..:
  Rat   385 PTFPT-QRPIPGIPTV------LNPVQVSSGPSES---SQSKPTS--------ESAVSSTGDPMH 431

  Fly   396 NNVVNNITGIPGDVKVNSRLDEYINCGSISIPS-----NEYDCANADTTDIKDEPGDFIETNCHW 455
            |.        ...:|.:..|....:.|....|.     .|    ..|..:.|.||....||||||
  Rat   432 NK--------RSKIKPDEDLPSPGSRGQQEQPEGTTLVKE----EGDKDESKQEPEVIYETNCHW 484

  Fly   456 RSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCT 520
            ..|..||.|||:||.|||||||...||.|||||.||:|.:|||||||||||||||||||||||||
  Rat   485 EGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCT 549

  Fly   521 FEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGC 585
            ||||.||||||||||||||||||||||.||:.||:|||||||||||||||||||||||:||.|||
  Rat   550 FEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGC 614

  Fly   586 TKRYTDPSSLRKHVKTVHGAEFYANKKHKG------LPLNDANSRLQQNNSRHNLQ-----EHNI 639
            |||||||||||||||||||.|.:..||.:|      .|..|:.|..|..:.....|     :..:
  Rat   615 TKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKEL 679

  Fly   640 DSSPCSEDSHL------GKMLGTSSPSIKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNL 698
            .::....:..|      .:...||.||...:|..||....:.|          ||...|  .|.|
  Rat   680 SNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISN----------YSNSGL--ELPL 732

  Fly   699 DDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIP 763
            .||.:..|...:.:.||:        :...|.:|   :.||.|..|....||.:..  |.|..:.
  Rat   733 TDGGSIADLSAIDETPIM--------DSTISTAT---TALALQGRRNPAGTKWMEH--IKLERLK 784

  Fly   764 ESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTT------IGGYTEDPLQNQTS-------- 814
            :.|..|  ..||                  |.||:..      ||..|:.. .|.:|
  Rat   785 QVNGMF--PRLN------------------PILPSKAPAVSPLIGNGTQSN-NNYSSGGPGTLLP 828

  Fly   815 FRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGS----------MQSRRSSQSSQVSSIPTMRP 869
            .|:.:|....||..::.   ||||..||.|:.|.|          ..|||||::||...
  Rat   829 SRSDLSGVDFTVLNTLN---RRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEG------ 884

  Fly   870 NPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTS----------------TSG-----LPVLN 913
            .|...|.|..|||||...|||||:.|.|....|..|                |.|     ||.:.
  Rat   885 RPQNVSVADSYDPISTDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHME 949

  Fly   914 KESNKSLNACINK-PNIGVQGVGIYNSSLPP--PPSSHLIATNLKRLQRKDSEYHNFTSGRFSVP 975
            |.|.|:..|.:.: .:.||        :|||  ||.           :..|...|.: |.|..:|
  Rat   950 KLSLKTRMALLGEGRDSGV--------TLPPVHPPR-----------RCSDGGGHTY-SRRHLLP 994

  Fly   976 SYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLD-PLTNISRFSTTPHSFDINVGKTNN 1039
               |.                |:|::|||.:|||..::.: .|..:.|||:      :|.....|
  Rat   995 ---HD----------------ALANSARRASDPVRTVSENMSLPRVQRFSS------LNSFNPPN 1034

  Fly  1040 IASSINKDNLRKDLFT----------------------VSIKADMAMTSDQHPNERINLDEVEEL 1082
            :..|:.|.:|....:|                      |:::| :.|.:|...|        :|.
  Rat  1035 LPPSVEKRSLVLQNYTRQESTHPRYFQASPCPPSITENVALEA-LTMDADASLN--------DED 1090

  Fly  1083 ILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSET--------IASNHYREQSNIYYTNKQILT 1139
            .|||:::|||| .::.|.:.::...::.....|:..        :..:|..:|   |...:|..:
  Rat  1091 FLPDDVVQYLN-SQNQTGYGQQLQSSISEDGKVAREPEDLDLPGLPDSHVGQQ---YPALEQPCS 1151

  Fly  1140 PPSNVD--IQPN----------TTKF------TVQD------------------KFAMTAVGGSF 1168
            ..|..|  ||.|          ::|.      |||.                  |......|||.
  Rat  1152 EGSKTDLPIQWNEVSSGSSDLSSSKLKCGQRPTVQQARGFGLYSNMVVHPQNLWKVGTGPAGGSQ 1216

  Fly  1169 SQRELSTLAVPNEH--GHA------KCESFHHQSQKYMNTDIGSK------QQSALPSA----HQ 1215
            :..|..:.....||  .|:      ..::||.|:  |.....||:      ..|.|.||    .|
  Rat  1217 TLGENGSSYSDPEHFAVHSGDGLGPSGDTFHEQA--YKTQQYGSQLSRQPLTSSVLDSACGAGIQ 1279

  Fly  1216 RQTEKSNYNQ----IIDSSMTSLPELNVDSIYPRNETENIFKVHGDHDNEIQCGIISQSQMSPST 1276
            ....|.|..|    ::|..::..|....|:|....:|:          .::..|.|:...:|.|.
  Rat  1280 GSKLKGNSLQENGGLLDFGLSMAPNELADNIVNGIQTQ----------EQMGQGYIAPQLLSGSM 1334

  Fly  1277 N-----------LNNDGQFSTVNMQ-------PITTSKLFPPEPQKIV-----CD---------- 1308
            .           |...|..|.:|:.       |.|..|:..|....::     |.
  Rat  1335 QHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDKISQPSSMAVIRGYQPCASYGGSRRQAM 1399

  Fly  1309 ---------------TQASNTSVMHLDTYQRTLEYVQSCQNW----------------------- 1335
                           :|.|..:.:.::.:.::.:...|.||:
  Rat  1400 PRGSLTLQQGQLSDVSQTSRVNSIKMEAHGQSHQLCSSMQNYSGQFYDQTMGFSQQDRKAGSFSL 1464

  Fly  1336 ------METNNTSTNQIQSLPGM-PVNNTL----------------------------------- 1358
                  ::.|.:..:::.| ||: .|.:|:
  Rat  1465 SEANCLLQENGSENSELLS-PGVNQVTSTVDSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSPS 1528

  Fly  1359 --------------------FPDVSSSTHPYHGTNMVINDMTTSLTSLLEENRYLQMMQ 1397
                                ||.:|.||     |||.|.||::.||||.||:::|.:||
  Rat  1529 IIQNLSHSSSRLTTPRASLPFPSLSMST-----TNMAIGDMSSLLTSLAEESKFLAVMQ 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	17/17 (100%)
		SFP1	<513..603	CDD:227516	82/89 (92%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:463886	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
Gli3	NP_536330.2	SFP1	<542..632	CDD:227516	82/89 (92%)
		C2H2 Zn finger	548..570	CDD:275368	20/21 (95%)
		C2H2 Zn finger	578..601	CDD:275368	19/22 (86%)
		C2H2 Zn finger	609..630	CDD:275368	19/20 (95%)