DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ci and gli1

DIOPT Version :9

Sequence 1:	NP_524617.3	Gene:	ci / 43767	FlyBaseID:	FBgn0004859	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_002939471.1	Gene:	gli1 / 100494064	XenbaseID:	XB-GENE-482644	Length:	1371	Species:	Xenopus tropicalis

Alignment Length:	1598	Identity:	435/1598 - (27%)
Similarity:	595/1598 - (37%)	Gaps:	568/1598 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IPGYMEQLYSLQRTNSASSFHD-PY---VNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVA 175
            :..|:|..|.......|...:: ||   .|..::.|  |.||
Frog    19 VNSYVEHCYLRSPNVMAEGMNEMPYCHQTNLMTSHH--GFGL----------------------- 58

  Fly   176 AAAAGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD-SFDINSMIRFSPNSL 239
            |.|:..||.||.       .|..:||.     ...:|:|||:|.||.|| |.|:.:|||.|||||
Frog    59 AQASDHLAGTDV-------SRFSTPRN-----TMKLSKKRAMSISPLSDASIDLQTMIRTSPNSL 111

  Fly   240 ATIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLL--NPMTPQQVAASG 302
            ...:| ||.|| |||||||:|...::|     |...|....| .|...|..  ||:.|..
Frog   112 VAFIN-SRCSS-ASGSYGHLSIGTISP-----SLGYQNCLNH-QRPQGGSYGNNPLMPYN----- 163

  Fly   303 FSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKKGPFKDVV 367
             |..||   :|..|..:.|..|..|.|:.:.|..:..:..:.:     |.|:|..|     .|:
Frog   164 -SHDHM---SSRGVGMLQPRSSIKHCQLKSEPLSSTGLDPIGS-----KRLEDGSE-----GDI- 213

  Fly   368 PEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYINCGSISIPSNEYD 432
             ..|:|.                      ...:.:.|:     ::.|.|
Frog   214 -SSPASV----------------------GTQDPLLGL-----LDGRDD---------------- 234

  Fly   433 CANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCTRGEKP 497
               .:..|.|.||....||||||.||..||.||:.||.||||:||...||.|||.|:||:|..:|
Frog   235 ---LEKDDGKHEPETVYETNCHWESCTKEFDTQEHLVHHINNEHIHGEKKEFVCHWQDCSRELRP 296

  Fly   498 FKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNAS 562
            |||||||||||||||||||||||||||.||||||||||||||||||||||.||:.||:|||||||
Frog   297 FKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNAS 361

  Fly   563 DRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLNDANSRLQ- 626
            ||||||||||||||||:||.||||||||||||||||||||||.|.:..|||:|    |...|.|
Frog   362 DRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRG----DGMPRTQS 422

  Fly   627 --QNNSRHNLQ-EHNID---SSPCSEDSHLG--KMLGTSSPSIKSESDISSSNHHLVNGVRASDS 683
              :.:..|.:: |:.:|   ||...||..|.  .:...|.||...:|..||..          ..
Frog   423 GHEGSGNHTVKGENQLDMEASSARKEDGRLAVPDITLKSQPSPGGQSSCSSER----------SP 477

  Fly   684 LLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGGSVLARQRFRGRLQ 748
            |.:.:.:|....:|.:.|.:.:|..::.|:|.|           .|..|.|.|.|.:
Frog   478 LGSTNNNDSGVEMNANTGGSFEDLTNLDDIPSV-----------DSIGTAGASALRK-------- 523

  Fly   749 TKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQT 813
                      |.|:       .|.:|||    |:..|.:...:|:|.:.|
Frog   524 ----------LENL-------RIDKLNQ----LRKAPSSGKMVKLPSIHN--------------- 552

  Fly   814 SFRNTVSNKQGTVS------GSIQGQF---------------RRDSQNSTASTYYGSMQSRRSSQ 857
                  |..||.:|      |....|.               ||:|..||.|:.|  ..|||||.
Frog   553 ------SGPQGDMSVVCGPLGMSHNQHGIELPSSSHVNHLNDRRNSTTSTMSSAY--TVSRRSSV 609

  Fly   858 SSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTSTSGLPVLNKESNKSLNA 922
            .|..  :|..|...|.|...| ||     .|...|..||.|.|     .||||.|.......|.|
Frog   610 VSPY--LPNQRAGDSGNMVDS-YD-----ISTDPSGHSNEAVC-----ASGLPGLTPAQQYRLKA 661

  Fly   923 CINKPNIGVQGVGIYNSSLPPPPS--------------------------SHLIATNLKRLQRKD 961
            .......|            |||:                          |.|:|.|:.| :...
Frog   662 KYAAATGG------------PPPTPLPNMERMNSNNRMAFASSDYRGSSMSSLLANNIHR-RHSS 713

  Fly   962 SEYHNFTSGRFSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPV-PNINLDPLTNISRFST 1025
            :||||:.:|      .:|..              :|..:..||.:||. ...::..:..:.||.:
Frog   714 NEYHNYGTG------IIHPA--------------QAPGAGIRRASDPARTGGDIQTVPKVQRFKS 758

  Fly  1026 TPHSFDINVGKTNNIASSINK------DNLRKDLFT---VSIKADMAMTSDQHPNERINLDEV-- 1079
            ..   ::||......||.|.:      .||::.:|:   .||..::.|       |....|.|
Frog   759 MT---NMNVSMMGRQASGIQQAYGGSDANLQRHMFSPRPPSISENVFM-------ETAGPDGVCH 813

  Fly  1080 ---EELILPDEMLQYLNL------VKDDTNHLEKEHQAVPV---GSNV---SETIASN------H 1123
               ..:|.|:||..|:|.      :...::|:...||...:   ..||   |:...||      :
Frog   814 SKDHSIIQPNEMQHYVNYQGQGSQLAAPSDHMNFNHQIHGIDGQSQNVYGHSQRAMSNMHLNSEN 878

  Fly  1124 YREQSNI----------------YYTNKQILTPPSNVDIQPNTTKFTVQDK---------FAMTA 1163
            |..|||:                ::.|.:.....||:.:|.|.......|.         .....
Frog   879 YSSQSNVPTQTNFNQCQMTGQSQHFQNTRQAYSSSNLPVQWNEVSSGTMDNPGQSPNHQIMHQNM 943

  Fly  1164 VGGSFSQRELSTLAVP-------------------------NEHGHAKC---ESFHHQSQKYM-- 1198
            ..|:..|.:.|...||                         |..|..:.   :.|||.:...|
Frog   944 PPGNHCQSQFSNSVVPETTKQGCPVNRSSCQQGMYMNNQKYNHGGQVQVKPEQQFHHSAPTMMSC 1008

  Fly  1199 -NTDIGSKQQSALPSAH----------------QRQTEKSNYNQIIDSSMTS-------LPELNV 1239
             |....|:|:.....::                |..|:.|.:|..::.::.|       .|.:.|
Frog  1009 QNMKHPSRQEHNFTQSNTMLLSPESTNCDFQGQQDNTQNSCFNVGLNPNLLSPQGRRSQTPMMQV 1073

  Fly  1240 DSIYPRNETEN----IFKVH------------------GDHDN-------------EIQCGIISQ 1269
            ..:..||..::    :::.|                  ..|.|             ..||.....
Frog  1074 KEMMVRNYVQSQQALMWEQHPKSMAMMNNSGEDVDTGQNQHKNTPNAAVYMSPKYINYQCKPSPN 1138

  Fly  1270 SQMSPSTNLNNDGQFSTV--------------------------------------------NMQ 1290
            :.||||:..:......|:                                            :.|
Frog  1139 NLMSPSSQDSQSSHTKTMGSPSSQCYNYDMLPHPPCGPKPLSRQHSISSQSTYMGSPNQHSPSYQ 1203

  Fly  1291 PITTSK-----LFPPEPQKIV-----------------------------------CDTQ----- 1310
            |..||.     |.|.:||..|                                   ||.|
Frog  1204 PSETSPRRMACLPPIQPQSEVSNNTSMMYYTGQMEMHHGKAGVHKLATSLNQNQTSCDGQQHGQY 1268

  Fly  1311 ASNTSVMHLDTYQRTLEYVQSC--QNWMETNNTSTNQIQSLPGM-PVNNTLF-----PDVSSSTH 1367
            :||.|.:..|    ::.|..||  .|.:::.:....||.....: ..:|||.     |:..:.|.
Frog  1269 SSNHSFLKTD----SVPYTSSCPGANTLDSLDLENTQIDFTAIIDDADNTLMSGNISPNGLAGTS 1329

  Fly  1368 P--YHGT----------NMVINDMTTSLTSLLEENRYL 1393
            |  .|.|          |||:.|:.:.||||..||:||
Frog  1330 PGSSHLTTLRNTGAVVPNMVVGDLNSMLTSLTGENKYL 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..530	CDD:290200	25/26 (96%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:290200	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
gli1	XP_002939471.1	SFP1	<312..402	CDD:227516	82/89 (92%)
		C2H2 Zn finger	318..340	CDD:275368	20/21 (95%)
		C2H2 Zn finger	348..371	CDD:275368	19/22 (86%)
		C2H2 Zn finger	379..400	CDD:275368	19/20 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5221
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1612
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47586
Panther	1	1.100	-	-	LDO	PTHR45718
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060