Protein Alignment ci and gli3

DIOPT Version :10

• Sequence 1: NP_524617.3
• Gene: ci / 43767
• FlyBaseID: FBgn0004859
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_004915407.1
• Gene: gli3 / 100101789
• XenbaseID: XB-GENE-484855
• Length: 1566
• Species: Xenopus tropicalis
• Alignment Length: 1706
• Identity: 469/1706 - (27%)
• Similarity: 675/1706 - (39%)
• Gaps: 573/1706 - (33%)

  Fly     4 YALPTYFPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPS-----IIPTGG 63
            |..|..||..:..:...|...........|.:|  |.   |.|:.::||.|.|.     |.|...
 Frog   122 YHPPHLFPSFHPPVPIDARHHEGRYHYEPTPIP--PL---HVPSALASSPTYPDLPFIRISPHRN 181

  Fly    64 TSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYMEQLYSLQRT 128
            .:.:..:...|                               ||.:     |..||:.:.||..:
 Frog   182 PASASDSPFSP-------------------------------PHPY-----ISPYMDYIRSLHSS 210

  Fly   129 NSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAV---------------AAAA 178
            .|.|...            |..||...| :...|:|.....|..|:               |.|.
 Frog   211 PSLSMIS------------AARGLSPTD-VPHAGVSPAEYYHQMALLTGQRSPYADIIPSPATAG 262

  Fly   179 AGSLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSD-SFDINSMIRFSPNSLATI 242
            ||:.|....:.....:.|..|||.|   :|.  ||||.||.||.|| |||:.:|||.|||||.||
 Frog   263 AGANALHMEYLHAMESSRFSSPRVP---LRP--SRKRTLSISPLSDHSFDLQTMIRNSPNSLVTI 322

  Fly   243 MNGSRGSSAASGSYGHISATALNP-MSHVHS---TRLQQIQAHLLRASAGLLNPMTPQQVAASGF 303
            :|.||.||:|||||||::|:|::| :|..:.   ..|||:...|          |:.|....|.|
 Frog   323 LNNSRSSSSASGSYGHLAASAISPALSFTYQPTPVSLQQMHQQL----------MSRQHSIGSAF 377

  Fly   304 SIGHMPTSASLRVNDVHPNLSDSHIQITTSPTV--TKDVSQVPAAAFSLKNLDDAREKKGPFKDV 366
              ||.|..       :||           :||.  .:.:..:|:.      |:..:...||.:..
 Frog   378 --GHSPPL-------LHP-----------APTFPSQRTIPGIPSV------LNPVQVSIGPSEAA 416

  Fly   367 VPEQPSSTSGGVAQVEADSASSQLSDRCYN--NVVNNITGI--PGDVKVNSRLDEYINCGSISIP 427
            ...:|:|          :||.|...|..:|  :.|.....:  ||.|.:..:.|      .:::.
 Frog   417 QQNKPTS----------ESAVSSTGDPLHNKRSKVKPEEDLPSPGAVCIQDQPD------GMTLV 465

  Fly   428 SNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTNKKAFVCRWEDCT 492
            ..|     .|..:.|.||....||||||..|..||.||::||.|||||||...||.|||||.||:
 Frog   466 KEE-----GDKDESKQEPEVVYETNCHWEGCSREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCS 525

  Fly   493 RGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKA 557
            |.:|||||||||||||||||||||||||||||.||||||||||||||||||||||.||:.||:||
 Frog   526 REQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKA 590

  Fly   558 FSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKG------L 616
            |||||||||||||||||||||:||.||||||||||||||||||||||.|.:..||.:|      .
 Frog   591 FSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPP 655

  Fly   617 PLNDANSRLQQNNSRHNLQ----EHNIDSSPCSEDSHLGKMLG-------TSSPSIKSESDISSS 670
            |..:..|..|..:...::|    ||...|:..|:.....::..       ||.||...:|..||.
 Frog   656 PPREPGSHSQSRSPGQHIQGTHGEHKDLSNTTSKHEECLQVKSVKTEKPMTSQPSPGGKSSCSSE 720

  Fly   671 NHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAMVNIGNGNASASTIGG 735
            ...:.|          |:...:  .|.|:.|.:..|...:.:.||:        :...|.:|.|.
 Frog   721 QSPVSN----------YTNSGI--ELTLNSGGSIGDFSALDETPIM--------DSTISTATTGL 765

  Fly   736 SVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITELKMEPGTDAEIKIPKLP--- 797
            .:..|:...|   ||.:           |..:...|.::|..:..|...|...|    |.||
 Frog   766 GLHGRRIMTG---TKWM-----------EQIKVEKIKQVNGILPRLNPVPPHRA----PNLPPIT 812

  Fly   798 --------NTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQNSTASTYYGS----- 849
                    |.::|| :...|.|    :|.:|:...||...:.   ||||..||.|:.|.|
 Frog   813 GNGVQLNSNISLGG-SAPVLPN----KNELSSMDITVLNMLN---RRDSNTSTISSAYMSSRRSS 869

  Fly   850 -----MQSRRSSQSSQ----VSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANCNSFTS 905
                 ..|||||::||    |.:|          |.|..|||||...|||||:.|   .|:...|
 Frog   870 GISPCFSSRRSSEASQFEGRVQNI----------SVADSYDPISTDASRRSSETS---QCDGLPS 921

  Fly   906 TSGL-PVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLK-RL----QRKDSEY 964
            ...| |...........|....|              ||.|..::...:|| |:    ..:|...
 Frog   922 LLSLTPAQQYRLKAKYAAATGGP--------------PPTPLPNMERMSLKTRIALLGDSRDCRL 972

  Fly   965 HNFTSGRFSVP---------SYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTN- 1019
            ....|  .:||         ||... |:.:|:..|         :..||.:|||..:: |..:|
 Frog   973 SPLPS--VNVPRRCSDGGVGSYGRR-HLLSNELQG---------NGMRRASDPVKMVS-DNFSNA 1024

  Fly  1020 -ISRFSTTPHSFDINVGKTNNIA----------SSINKDNLRKDLFT---------VSIKADMAM 1064
             :.||::           .|||.          .:::..|..:::::         |:::| |.|
 Frog  1025 RVPRFNS-----------LNNITPPDAPPLMERRNLSLQNYTRNVYSPCPPSISENVALEA-MIM 1077

  Fly  1065 TSDQHPNERINLDEVEELILPDEMLQYLN--------LVKDDT----------NHLEKEHQAVPV 1111
            .::.      |.|  :|.:|||:|:||||        :.:.|.          |:.|..|    |
 Frog  1078 EAEG------NFD--DEDLLPDDMVQYLNSRNQRLYDIFETDKLQNNAGERNGNNFEPSH----V 1130

  Fly  1112 GSNV----------SETIA-----------------------------------------SNHYR 1125
            .||:          ::||.                                         :|...
 Frog  1131 TSNIINEQFLNSEQTDTIENKNDLPIQWNEVSSGSAEYSPSRLKYGQRLTTQQNRPFGLYNNMMV 1195

  Fly  1126 EQSNI------------YYTNKQILTPPSNVDIQPNTTKFTVQDKFAMTAVGGS----FSQRELS 1174
            :|.|:            ::|......|..|:::..|::.::.|      :|.|:    .::..|.
 Frog  1196 QQQNVPKNGLPQQRSYQHHTQNNPQVPQQNLNLYNNSSVWSGQ------SVRGNQCIDIARSSLG 1254

  Fly  1175 TLAVPNEHGHAKCESFHHQSQKY----MNTDIGSKQQSALPSAHQRQTEKSNYNQIIDSSMTSLP 1235
            |.|.     .:.|.:  .:.||:    :..:||  ||:..||.|......|..:.:.:.::
 Frog  1255 TSAT-----GSLCNT--TRGQKFTANGLQMNIG--QQNYGPSTHYSVQSASRTDPVQNENI---- 1306

  Fly  1236 ELNVDSIYPRNETENIFKVH------------GDHDNEIQCGIISQSQMSPSTN----------- 1277
             :|.:.::.......|:.:|            |.:.|.|..   :||.:|.:.|
 Frog  1307 -MNQEFMHQMTAEHLIYGMHFLGVTRSNQTTSGQNGNTIDA---TQSFLSTTQNAGEQQPSLAKN 1367

  Fly  1278 ----LNNDGQFSTVNMQPITTSKLFPPEPQKIVCDT--QASNTSVMHLDTYQRTLEYVQSCQNW- 1335
                :|:.|. |..|:.....|.|     |:.:|||  |....:.:.::......::..:.||:
 Frog  1368 IQSFVNSSGN-SRQNIHRNNLSYL-----QEQICDTNQQVCRVNGIKMEMQNHPQQHCANAQNFS 1426

  Fly  1336 -----------------------------METNNTSTNQIQSLPG-----MPVNN---------- 1356
                                         .|:|||:::|:.| ||     ..|||
 Frog  1427 GQLYDQTAAYPQQSIKSGSEPGMEANCLLQESNNTNSSQLLS-PGANQVTSTVNNIDSSLDEVQI 1490

  Fly  1357 ----------------------------------------TLFPDVSSSTHPYHGTNMVINDMTT 1381
                                                    ..||.:..||     :||.|.||::
 Frog  1491 DFDAIIDDGDHASLISGALSPSIIQNLSRNSSRLTTPRTSLTFPAIPVST-----SNMAIGDMSS 1550

  Fly  1382 SLTSLLEENRYLQMMQ 1397
            .||||.||:::|.:||
 Frog  1551 LLTSLAEESKFLAIMQ 1566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ci	NP_524617.3	zf-H2C2_2	503..>521	CDD:463886	17/17 (100%)
		SFP1	<513..603	CDD:227516	82/89 (92%)
		C2H2 Zn finger	519..541	CDD:275368	20/21 (95%)
		zf-H2C2_2	533..560	CDD:463886	22/26 (85%)
		C2H2 Zn finger	549..572	CDD:275368	19/22 (86%)
		C2H2 Zn finger	580..601	CDD:275368	19/20 (95%)
gli3	XP_004915407.1	PHA03247	<54..441	CDD:223021	110/423 (26%)
		SFP1	<546..636	CDD:227516	82/89 (92%)
		C2H2 Zn finger	552..574	CDD:275368	20/21 (95%)
		C2H2 Zn finger	582..605	CDD:275368	19/22 (86%)
		C2H2 Zn finger	613..634	CDD:275368	19/20 (95%)