DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexB and PKHD1L1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:XP_016869458.1 Gene:PKHD1L1 / 93035 HGNCID:20313 Length:4253 Species:Homo sapiens


Alignment Length:2474 Identity:436/2474 - (17%)
Similarity:734/2474 - (29%) Gaps:975/2474 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 SYGN---------------RSIGNNIESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLN--- 111
            :|||               :..|.|:...|.|..|   ...|..|..:|::.|.|:.|..|:   
Human   783 AYGNNWTYTCIDLLDLVRTKYTGTNVSLQRISLHK---ASESQSFYVDVVYIGHTSTISTLDEMP 844

  Fly   112 --------------ENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSLVNNFNKILVVSYAHDGIL 162
                          |:.:|......||                  ::.|.:: :.:.||      
Human   845 KRRLPALANKGIFLEHFQVNQTKTNGP------------------TMTNQYS-VTMTSY------ 884

  Fly   163 IACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYV------- 220
                     .|. |::|....:   |...:....||...|     ....|..|..:::       
Human   885 ---------NCS-YNIPMMAVS---FGQIITHETENEFVY-----RGNNWPGESKIHIQRIQAAS 931

  Fly   221 ---GTTFTNVGDYRH---DVPAISSRRLDDLNYAEFSIQ-QSIINI-----------DVKYRDHF 267
               ..:| ::..|.|   .:||..|..  ||.:|..|:: ...|::           ::|:|...
Human   932 PPLSGSF-DIQAYGHILKGLPAAVSAA--DLQFALQSLEGMGRISVTREGTCAGYAWNIKWRSTC 993

  Fly   268 LVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTR--------------LARICITDPNYDSYTE- 317
            ....:...|.|.     |:.:|:::.     |||              |.|.....|..:.|.. 
Human   994 GKQNLLQINDSN-----IIGEKANMT-----VTRIKEGGLFRQHVLGDLLRTPSQQPQVEVYVNG 1048

  Fly   318 ITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTV---FSPSR--EISNQPESKS 377
            |..:|:.     |.....|:.:||....::...|..::..:|..|   ||||.  .:|..|...|
Human  1049 IPAKCSG-----DCGFTWDSNITPLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCS 1108

  Fly   378 AMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIYNFCSVG------ 436
            .:.: ..|:::...:       ||:.              |..|:..|:.::....:||      
Human  1109 LLSV-DEKELKCQIL-------NGSA--------------GHAPVAVSMADVGLAQNVGGEEFYF 1151

  Fly   437 ---LKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEE 498
               .:||.:.|         |:.|:...|.         |...|.......|||:..::....|.
Human  1152 VYQSQISHIWP---------DSGSIAGGTL---------LTLSGFGFNENSKVLVGNETCNVIEG 1198

  Fly   499 IVVDAGNRILPNTMMSPKKD--------------------FLYVLSQRKI-----TKLR------ 532
            .:    |||   |..:|||.                    |.|...|..|     .|:|      
Human  1199 DL----NRI---TCRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEV 1256

  Fly   533 -------------IEHCSVYTNCSACLESRDPFCGWCSLEKRC--------------TVRS---T 567
                         .::.:||.....|     ....|...:.||              .||:   .
Human  1257 NLTIKGYNFGNELTQNMAVYVGGKTC-----QILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFA 1316

  Fly   568 CQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDA 632
            ..||...|      |.|..:|..|:.|::                        ..:||.:     
Human  1317 STRDKLNS------SIQYVLEVTSMFPQR------------------------GSLFGGT----- 1346

  Fly   633 EILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETN-------------------KDFV--- 675
            ||...|.|.:|.|.:...|:.:      :|.:|.||..|                   ||.|   
Human  1347 EITIRGFGFSTIPAENTVLLGS------IPCNVTSSSENVIKCILHSTGNIFRITNNGKDSVHGL 1405

  Fly   676 ----------------------------SRNFAFFDCSHHGNC-----------QECLQSSWGCN 701
                                        ...:..|..|..|:.           |:....|:...
Human  1406 GYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGYRIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQ 1470

  Fly   702 WCIFDNKCVH----------KSLQCRNIENAV-STVGHCP-HLKKNRPEILLPVRVPIEIRLEIE 754
               |.:..:|          .|:..:.:.|.: :...|.| ||...|.|.......|       |
Human  1471 ---FTSPGIHYYSSGYVDEAHSIFLQGVINVLPAETRHIPLHLFVGRSEATYAYGGP-------E 1525

  Fly   755 NLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEK-----------TPYFYEINTHEYQAK 808
            ||....|. ||.|.|   |....|....|:::|.::.|.           ||....:|    :..
Human  1526 NLHLGSSV-AGCLAT---EPLCSLNNTRVKNSKRLLFEVSSCFSPSISNITPSTGTVN----ELI 1582

  Fly   809 VVVTWNFQH--YVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNS-----------C 860
            .::...|.:  :.:...:..|.|.|..|..:...|.:    ||:       ||           .
Human  1583 TIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHI----DPQ-------NSMDVGIRETVTLT 1636

  Fly   861 VYN-ETCIADKNSISSGSKSAIENECP-----LPRIDIIKPLSGPVEGGTLITIEGSNLGIREED 919
            ||| .|.|   |::|        ||..     ||.||::.|.:|...|.|.:||:||...:....
Human  1637 VYNLGTAI---NTLS--------NEFDRRFVLLPNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAG 1690

  Fly   920 VRGKIFIGSVPCEL--ENYQISVKIECRTGASLYEM--------SAPIKVANDAGFT--ESSVQF 972
            |  |:.:|..||::  .||   ..|||.|..:..::        ..|.:...:..|:  ||...:
Human  1691 V--KVLMGHFPCKVLSVNY---TAIECETSPAAQQLVDVDLLIHGVPAQCQGNCTFSYLESITPY 1750

  Fly   973 HFKNVLLTGLYPTIGPRSGGTQLSLIG--KFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSE 1035
                  :||::|.          |:||  |.|..|..:...|::....|...|..:.:|:.....
Human  1751 ------ITGVFPN----------SVIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNIT 1799

  Fly  1036 A-TQPEPI--RSLHLVIDGANRTL-ECQISTPSITNTNPTRSNFG--------------SYQLRS 1082
            | ..|.|:  .|:.:|:......| ...:|:|.:.:.:||..:.|              .....:
Human  1800 ALVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGSIGGGTTLVITGNGFYPGNTTVT 1864

  Fly  1083 LPRQPCSIFN------YTQDPR----IMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNE 1137
            :..:||.|.:      |.:.|.    ::.:|                |::|:|..|.|...|..|
Human  1865 IGDEPCQIISINPNEVYCRTPAGTTGMVDVK----------------IFVNTIAYPPLLFTYALE 1913

  Fly  1138 RVNKTSCVVINSNQMECPS--PP--------VNYKFETFKKTNRKMDTELHLQNSSFQTETRYKN 1192
            .......::        ||  ||        .|:.||..         |:.:..::.|......|
Human  1914 DTPFLRGII--------PSRGPPGTEIEITGSNFGFEIL---------EISVMINNIQCNVTMAN 1961

  Fly  1193 EYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQL-VRNLN 1256
            :                     |.....|.::...|..|.:|.......:|.|:....| ::|:|
Human  1962 D---------------------SVVQCIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNIN 2005

  Fly  1257 KYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLA 1321
                                 |:.| ....|.::.:.|...|   .:..:.:..| |:|.|..|.
Human  2006 ---------------------PSQG-SFGGGQTMTVTGTGFN---PQNSIILVCG-SECAIDRLR 2044

  Fly  1322 --LNQLLCIPPEQQPLPTDE-------NGVDQSTDL----------PLV---------------- 1351
              ...|||..|.......::       ||.|.|..:          ||:                
Human  2045 SDYTTLLCEIPSNNGTGAEQACEVSVVNGKDLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRL 2109

  Fly  1352 -VVKVG-----RNLRFVIGYLKYDL---NKPYVF----SHAL---------LVGILTVALLVVVF 1394
             ||..|     .::...|...|.|:   ||.::.    :|.|         :.|:....|....|
Human  2110 TVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHIRGVGMAKLDNADF 2174

  Fly  1395 VIV-------------------LIIFRRKST----QAEREYKRIQIQMITLESNVRSECKQAFAE 1436
            :.|                   |::..:..|    |:....|.:.||..||..:      :|..|
Human  2175 LYVDAWSSNFSWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQGGTLIFD------EADIE 2233

  Fly  1437 LQTD---MTD--------LTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKF--------- 1481
            ||.:   :||        .|:..:...:.||                |..|.||:.         
Human  2234 LQAENILITDGGVLQIGTETSPFQHKAVITL----------------HGHLRSPELPVYGAKTLA 2282

  Fly  1482 -REGSPQTNYDAAMVQFEQL-----IGNKYFLLMFIETLE----------AQRSSFSIRDRVNVA 1530
             |||....:.....|.:.:|     .|.:..:|....|.:          ..|.|....:::.:|
Human  2283 VREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGDNIVIASTGHRHSQGENEKMTIA 2347

  Fly  1531 SL----IMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQ-------LMLRRTESVV-------- 1576
            |:    |.:.|.|.:.| |.:  .:.:.|.|.:|.....:       :::|.:::|.        
Human  2348 SVSADGINITLSNPLNY-THL--GITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPAC 2409

  Fly  1577 --------------------EKMLTNYLAICM---------------YDYLKEYAGSNLF----- 1601
                                |::.::....|:               .:|::.:.....|     
Human  2410 PDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRY 2474

  Fly  1602 ---------LLFKAIKH--QIEKGLVDAITNDARYSLSEER-----------LLHEQVTHSVVIL 1644
                     |.||:...  .|.:....|:|....:.|..||           .:.:.:.|..::.
Human  2475 PIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQ 2539

  Fly  1645 H-----------ILQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHG 1698
            :           :|.||:........|..:||..      :|:...|.|.....:|      .|.
Human  2540 YNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRH------NAVAGGTHFGFWYRMN------NHP 2592

  Fly  1699 RGGHLTLQDEDLTTKTV------------NGWKRLNTLAHY----------GVKESAVMSLIARQ 1741
            .|   ...|.::..|.|            .||..:.....|          .|...|:.:.:...
Human  2593 DG---PSYDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTSTVPAPAIFNSLTTW 2654

  Fly  1742 NDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVY------------------- 1787
            |......: .|..:..:|||..:||          .|:|::..|:.                   
Human  2655 NCQKGAEW-VNGGALQFHNFVMVNN----------YEAGIETKRILAPYVGGWGETNGAVIKNAK 2708

  Fly  1788 ---HLVKPNIPDHYMNIKNSVL--SGGSPAFQSHVVN----------------NCNDRVNKTIPE 1831
               ||.:..:...:...|..||  |.|......|.:|                .||||..     
Human  2709 IVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSISGVCNDRCG----- 2768

  Fly  1832 VYLTRLLATKGTIQKFVDDFFSIILTVNEELPPAVKWLFDL----LDEAARRHDIADTDIVHAW- 1891
                      |...||||..:|  .|.|:   ...:|..::    :|.:...|. ..|.|.|:. 
Human  2769 ----------GWSAKFVDVQYS--HTPNK---AGFRWEHEMVMIDVDGSLTGHK-GHTVIPHSSL 2817

  Fly  1892 --KSNCLPLRFW-VNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLF 1953
              .|:|.....| :.|   |..:.|                     .|.|.|||..:.||...|.
Human  2818 LDPSHCTQEAEWSIGF---PGSVCD---------------------ASVSFHRLAFNQPSPVSLL 2858

  Fly  1954 AKDI 1957
            .||:
Human  2859 EKDV 2862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 96/562 (17%)
PSI 535..586 CDD:279745 13/67 (19%)
PSI 683..730 CDD:214655 9/68 (13%)
PSI 836..877 CDD:214655 12/52 (23%)
IPT_plexin_repeat1 888..976 CDD:238585 26/99 (26%)
IPT_plexin_repeat2 977..1095 CDD:238584 28/143 (20%)
IPT_plexin_repeat3 1097..1211 CDD:238586 19/127 (15%)
Plexin_cytopl 1452..2017 CDD:285529 115/693 (17%)
PKHD1L1XP_016869458.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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