Protein Alignment PlexB and plxnc1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_021330924.1
• Gene: plxnc1 / 562273
• ZFINID: ZDB-GENE-030131-1620
• Length: 1480
• Species: Danio rerio
• Alignment Length: 2019
• Identity: 479/2019 - (23%)
• Similarity: 771/2019 - (38%)
• Gaps: 645/2019 - (31%)

  Fly    93 DFMHNVL-FAGATNKILKLNEN----LRVLAEAVTGPLHDSPQCHAGGCPEDIETSLVNNFNKI- 151
            ||..::. |...|:|:..|.||    :|          ||..:       |..:..:.|:.:.|
Zfish    22 DFGEDIKDFVVGTSKLFVLTENRLYQMR----------HDLSE-------EKKKKDINNSTHPIN 69

  Fly   152 LVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTY----AFVGPARYAW 212
            ::|.:.::|.||.||:...|.||:                |..||...|.|    .|:||..
Zfish    70 ILVPFDNNGTLITCGTYEHGYCEV----------------LDINDITNSIYFESKLFMGPKE--- 115

  Fly   213 KEEDILYVGTTFTN----VG----DYRHDVPAISSRRLDDLNYA---EFSIQQSIINIDVKYRDH 266
            .|:.|.::.:|.::    ||    ......|.::.|......:.   .:|.:.|...|....||
Zfish   116 TEKSIAFIASTSSSRYLLVGKKLDQSTSQSPVVTLRNTVQTQFGGIFSYSEEGSDPAIQTTARD- 179

  Fly   267 FLVDYIYGFN--SSEYAYFIIVQK-----KSHLADEAGYVTRLARICITDPNYDSYTEITVQCTA 324
              |:::.||.  ||...|..:..|     |.|:....|..::.:.|      :.|.....::|.:
Zfish   180 --VEFVDGFQRASSLDLYLFLNTKTDSEWKVHVLRMDGSKSKKSEI------FRSLKSAVIKCCS 236

  Fly   325 TENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIED 389
            .:..   .::..:.|.|:...:           :...|||...:  ..||: :|:.:|.|..|:
Zfish   237 DKAR---PVLVSSAVIPSEKTV-----------IWAGVFSAQDQ--QDPEN-TALALYDISRIQ- 283

  Fly   390 MFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIYNFCSVGLKI----SGVSPITAHAL 450
                                                 |.:..||:.|.|.    |.:.|::.
Zfish   284 -------------------------------------GRVKEFCTQGEKTCSSESDLQPLSV--- 308

  Fly   451 FHFDNVSVTSVTATSTTDQQHSLAFLGTNMG-VIKKVLLSGQSPG----EYEEIVVDAGNRILPN 510
             .|.:.|::||.|  ..:....:.|:|.:.| :||.||....:|.    .|:.   |....:.|.
Zfish   309 -VFKSSSMSSVAA--VRNGSWIVLFMGNSDGQLIKLVLDENYTPSCPTVLYKS---DDERAVFPR 367

  Fly   511 TMMSP-KKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSA 574
            ....| ...::|:..:::|.::.:..|:.|.....|..:.||.||||...:||:....|    |.
Zfish   368 MHFDPVDSKYIYIALRKQIRRVSVVRCAKYNTLKDCRSALDPLCGWCVNTQRCSTHDEC----SN 428

  Fly   575 SRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGL 639
            |.|:|:.......|..|....:.|.:::: |||.: :|....|..:.|||.:.    :..|.||
Zfish   429 SSWVSIPKDSLQTELLSFQVAQKPSTQIT-LHLAL-SLESTGNPAFSCVFSSG----SVNLCNG- 486

  Fly   640 GCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCI 704
                                            .|..:   .|.:||                 |.
Zfish   487 --------------------------------SDLTA---VFPNCS-----------------CT 499

  Fly   705 FDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCT 769
            |.|:                                               ||     :.|...|
Zfish   500 FSNQ-----------------------------------------------LP-----NTGVSAT 512

  Fly   770 IHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGS 834
            :           .||..||                  .|:::..|.....|.:           .
Zfish   513 V-----------TVEDQKI------------------TKMLILTNCSSITDNS-----------P 537

  Fly   835 HREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGP 899
            :..:..|..|::..    |.|.|:|                       ..|            |.
Zfish   538 NVSYTQCVQCISSG----CHWSSSS-----------------------KRC------------GW 563

  Fly   900 VEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAG 964
            .:|             ||.                  |::::..|:...|.|      |......
Zfish   564 TQG-------------REP------------------QLNIQDACKDLLSEY------KEPEILS 591

  Fly   965 FTESSVQFHFK-NVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQ 1028
            .....|.|:.: ||||.|                    .|:.|..:..:             ...
Zfish   592 LEPHKVSFNGRNNVLLRG--------------------RNLDSVTKIRI-------------QGD 623

  Fly  1029 VSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSL-PRQPC---S 1089
            :.|...|:.          |.|.::.||        :.|..|:.|. |:.::..: |...|   |
Zfish   624 LGCIAKESP----------VFDPSSDTL--------VFNIPPSESK-GTVKMCVVTPDNRCHGNS 669

  Fly  1090 IFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMEC 1154
            |..|:..||...::|..|::||||.:.|.|..:..::                |.:|..||..
Zfish   670 IITYSSQPRCTGVQPRNSWRSGGRKIHVQGTNMEYVE----------------SVIVQPSNIF-- 716

  Fly  1155 PSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANY 1219
                                               .|::||...|...|      |::....:::
Zfish   717 -----------------------------------LKSQYDASSRDMWF------YSHRIEGSDH 740

  Fly  1220 FVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPF-----PN 1279
            |.                    ||.::.|     :.....||..    |..||.:..|     .|
Zfish   741 FT--------------------LSLMVGN-----STEACDHDFS----YEPDPVFTGFTTLQVAN 776

  Fly  1280 D-GVKLYKGDSLVIEGELLNLAADEYDVNVTIGTS--QCNITSLALNQLLCIPPEQQPLPTDENG 1341
            | .|.:.|      :.:.|||...|..|....|..  ||.:..:..|.::|
Zfish   777 DLQVNIQK------KADKLNLNISEVKVAGLHGDKGYQCVVERIESNAVIC-------------- 821

  Fly  1342 VDQSTDLPLVVVKVG----RNLRFVIG--YLKYDLNKPYVFSHALLVGILTVALLVVVFVIVL-- 1398
                      .:|.|    .:|...||  |:|.....|        .|:...::|||:.||::
Zfish   822 ----------KIKAGPGALDSLNISIGHFYVKQTFESP--------SGMKYFSILVVLIVIIILG 868

  Fly  1399 ----IIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTG-IPTLDH 1458
                :|..|||  .::..|::..|:..:|||:|.:.:|.|.:|||:.:||   :::.| ||.||:
Zfish   869 AVVGVIVHRKS--QKQMSKKMNDQLELMESNIRRDIRQGFVDLQTEKSDL---IDNVGAIPFLDY 928

  Fly  1459 VNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSI 1523
            .::..::|||.......:......|.|.||..|...:.|.:||.:|.||..|:..||.|: :|||
Zfish   929 KHFASRIFFPEAGTLTAVMIRDIGEDSEQTTVDEKCLAFAELIRDKQFLSCFVHALEEQK-NFSI 992

  Fly  1524 RDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICM 1588
            :|:..||||:.:.|...:.|.|||::.||..|:|:| ::.:|:|:||||||:|||:|||:::||:
Zfish   993 KDKCTVASLLTLALHGDLLYLTEIMEDLLQSLMDQS-SNANPKLLLRRTESIVEKLLTNWMSICL 1056

  Fly  1589 YDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLL-----HEQVTHSVVILHILQ 1648
            |.:|:|..|..||||..|:..||.||.||::|..|.|:|||:.||     .|.:...||......
Zfish  1057 YGFLRESVGQPLFLLVSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFEPLKLKVVFAVGTG 1121

  Fly  1649 DDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTK 1713
            :::.|.::......|||.|||.|||....:...|.....:.::::|:.. .|..:.||:.|.|::
Zfish  1122 EEISESLEVIALTCDTIQQVKEKILQTFQRKFGFRYTQQIRDIEIEYEK-EGKFVMLQEVDDTSE 1185

  Fly  1714 TVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIE 1778
            .......||||.||.|.:.|.:.:|   ....|.|. |.|||                 :.:|..
Zfish  1186 IRGHVTMLNTLKHYQVGDGACIKVI---TPKIHAPL-KTQNS-----------------VKDDKN 1229

  Fly  1779 SGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGT 1843
            ..:   :.:|||.|:|...                    ::|..::....|.|:||.:||:||..
Zfish  1230 FSI---KYFHLVDPDIDTD--------------------LSNHPEKKALKIKEMYLIKLLSTKVA 1271

  Fly  1844 IQKFVDDFFSIILTV-NEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKN 1907
            :..||::.|..|..: |.:.|.|||:.||.|||.|.|..|.|.|::|.||:|.||||||||.:||
Zfish  1272 VHSFVENLFKSIWGLPNNKAPLAVKYFFDFLDEQAERKKITDPDVLHIWKTNSLPLRFWVNILKN 1336

  Fly  1908 PDFIF-DVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDV 1971
            |||:| |:.|:..:|.|||||||.|||:.|.::..|.|.||:||||:.||||.|:..||.:|:.|
Zfish  1337 PDFVFSDMEKSPHLDGCLSVIAQAFMDSFSLTDTHLDKHSPTNKLLYGKDIPQYKQEVKSYYKLV 1401

  Fly  1972 SRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLE-TDI--NCRK-MHL 2032
            .....||.||:.|.:|:.|.:...||:..:||:|||.|:.:|..:|.:.|| ||.  |.:: ||.
Zfish  1402 KDQTSISSQELKTFLQEESKKHQNEFNESAALRELYKYMQRYFTEIFQKLEQTDAPSNLKENMHR 1466

  Fly  2033 SRKL 2036
            .::|
Zfish  1467 VKEL 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	93/478 (19%)
		PSI	535..586	CDD:396154	16/50 (32%)
		TIG_plexin	594..682	CDD:465588	13/87 (15%)
		PSI	683..730	CDD:214655	5/46 (11%)
		TIG_2	738..827	CDD:465619	11/88 (13%)
		PSI	836..877	CDD:214655	6/40 (15%)
		IPT_plexin_repeat1	888..976	CDD:238585	11/88 (13%)
		IPT_plexin_repeat2	977..1095	CDD:238584	21/121 (17%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	19/113 (17%)
		TIG	1277..>1334	CDD:460355	15/64 (23%)
		Plexin_cytopl	1452..2012	CDD:462434	213/567 (38%)
plxnc1	XP_021330924.1	Sema	75..391	CDD:472829	78/407 (19%)
		PSI	393..>430	CDD:396154	13/40 (33%)
		IPT	587..665	CDD:238050	20/129 (16%)
		Plexin_cytopl	923..1442	CDD:462434	212/565 (38%)