DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and plxnb2a.3

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_005164765.1	Gene:	plxnb2a.3 / 561237	ZFINID:	ZDB-GENE-041210-121	Length:	600	Species:	Danio rerio

Alignment Length:	656	Identity:	165/656 - (25%)
Similarity:	270/656 - (41%)	Gaps:	175/656 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESV 78
            :|....:::..||     :|.::...|..||                         :|.||:  |
Zfish    37 LLAAFSLLLCFGS-----SCCDDAQKQFSSP-------------------------TIINNV--V 69

  Fly    79 RDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETS 143
            :|.|:..             ::.||.|.|.:||.||:..:.|.|||..|:|||......:..:..
Zfish    70 QDPQTGR-------------IYLGAVNGIFQLNHNLQEESRADTGPKKDNPQCTPPITAKCTDAK 121

  Fly   144 LVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVGPA 208
            .::||||:|:|:.| :|.||.|||:.:|.|.:.:|                |..|...|......
Zfish   122 EMDNFNKLLLVNSA-NGTLIVCGSLFRGICSLVNL----------------NSVNKPVYYSDTKG 169

  Fly   209 RYAW---KEEDILYVG--------TTFTNVGDY--------RHDVPAISSRRLDDLNYAEFSIQQ 254
            ...|   .||.:..||        ||..|:..:        ......||:|.|.:  :.|..:.:
Zfish   170 EKTWVASTEESVTVVGVISYFKDTTTNANLSVFLVGKGYGSSDSSKLISTRLLQE--HGEMDVFE 232

  Fly   255 SIINIDV----KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSY 315
            :::....    .:...:|.|:.|.|..:.|.||:.  .:|....::..:|.:||:|..|.:|.||
Zfish   233 NMVEASTVQTSSFVHRYLHDFRYTFKDNGYIYFLF--SRSPGTSDSRRITFIARLCENDHHYYSY 295

  Fly   316 TEITVQCTA-TENNVD-YNIVRDAKVTPASHKLAQK-MGIKKDDHVLVTVFSPSREISNQPESKS 377
            ||:.:.||. ||...: :|.|:.|.:......|||. :....:|.||..|||     :::.:.:|
Zfish   296 TELQLNCTVNTEQQENTFNKVQAAYLAKPGKVLAQNIVPSNLNDKVLFGVFS-----ADEADGRS 355

  Fly   378 AMCIYSIKDIEDMFIENIHLCFNG------------------------TTKDRNL--GYISGTIN 416
            |:|:|.:..|...|.|.|..|:.|                        |.:|:|:  .||.|.
Zfish   356 ALCMYPLSSINARFEEVIESCYTGEVLEDDKPKTVYSPYNSKNEAICRTKRDKNMVKAYICGA-- 418

  Fly   417 DGRCPIVGSLGNIYNFCSVGLKISGVSPITA---HAL----FHFDNVSVTSVTATSTTDQQHSLA 474
                          .|..        ||:.:   :||    .:..|..:|:|..  ..:.:|::|
Zfish   419 --------------EFLP--------SPLASKPEYALAVKPIYTGNDMLTAVAV--AVENEHTVA 459

  Fly   475 FLGTNMGVIKKVLLS-------GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLR 532
            ||||:...:.||.|.       .:.|.|:.|..|:      .|.:.....|.||:.:.|||:|:.
Zfish   460 FLGTSGADVLKVHLDPNHTDFYNRIPEEHTEGAVN------KNLLFDTGLDHLYITTGRKISKVP 518

  Fly   533 IEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQC-----IEFESI 592
            ::.|....:|.:||..|||:||||..|.|||.:..|.:....:.|| .|..|.|     |:.::.
Zfish   519 VQVCGQKNDCRSCLVQRDPYCGWCVREGRCTRKKNCHKGEGENVWL-WGPDQACKILEPIKIQAC 582

  Fly   593 IPEKIP 598
            ||::.|
Zfish   583 IPDQTP 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	127/513 (25%)
		PSI	535..586	CDD:279745	20/50 (40%)
		PSI	683..730	CDD:214655
		PSI	836..877	CDD:214655
		IPT_plexin_repeat1	888..976	CDD:238585
		IPT_plexin_repeat2	977..1095	CDD:238584
		IPT_plexin_repeat3	1097..1211	CDD:238586
		Plexin_cytopl	1452..2017	CDD:285529
plxnb2a.3	XP_005164765.1	Sema	58..520	CDD:301699	136/559 (24%)
plxnb2a.3	XP_005164765.1	PSI	522..565	CDD:279745	18/43 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10728
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710