Protein Alignment PlexB and Plxnc1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_030101040.1
• Gene: Plxnc1 / 54712
• MGIID: 1890127
• Length: 1708
• Species: Mus musculus
• Alignment Length: 2002
• Identity: 477/2002 - (23%)
• Similarity: 773/2002 - (38%)
• Gaps: 663/2002 - (33%)

  Fly   133 AGGCPEDIETSLV--------NNFNKILVVSYAH-----DGILIACGSIRQGACEIYSLPRFPAT 184
            ||.|.|.:  ||.        ::|:|:| :.|..     :|:|:...:..:||||:..|.....:
Mouse   225 AGNCTEPV--SLAPPARPRPGSSFSKLL-LPYREGATGLEGLLLTGWTFDRGACEVRPLGNLNRS 286

  Fly   185 PQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVP-------------- 235
            .......:.:.....||...|    |.....|:.|:....|.|      :|
Mouse   287 SLRNGTEVVSCHPQGSTAGVV----YRASGTDLWYLAVAATYV------LPEPETANRCNPAASD 341

  Fly   236 ---AISSRRLDDLNYAEFSIQQSIINIDVKYRD-----HFLVDYIYGFNSSEYAYFIIVQKKSHL 292
               ||:.:..:..:.|...:.:      :|.|.     ||:..:::  |.|.|..:......|..
Mouse   342 RDTAIALKNTEGRSLATQELGR------LKLRGSAGSLHFVDAFLW--NGSVYFPYYPYNYTSGA 398

  Fly   293 ADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDH 357
            |  .|:.: :|||.       ..||:..|..|. .:.|:.       .|...:|.....:.:...
Mouse   399 A--TGWPS-MARIA-------QSTEVLFQGQAA-LDCDHG-------HPEGRRLLLSSSLVEAVD 445

  Fly   358 VLVTVFSPSREISNQPES--KSAMCIYSIKDIEDMFIENIHLC---FNGTTKDRNLGYISGTIND 417
            :...|||.:.....:..|  .:|:|::.:.:|:    .:...|   |..|..:
Mouse   446 IWAGVFSAATGEGQERRSPATTALCLFRMSEIQ----AHARSCSWDFQATEHN------------ 494

  Fly   418 GRCPIVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGV 482
                           |..|.:...|.||.:..|.|.|   :|||..|...::  ::.||||..|.
Mouse   495 ---------------CKEGDRPERVQPIASSTLIHSD---LTSVYGTVVMNR--TVLFLGTGDGQ 539

  Fly   483 IKKVLLSGQSPGEYEEIVVDAGN------RILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTN 541
            :.||:|.........|::.:...      :::|:.|   |..::|:.:.:::.::.:.:||...:
Mouse   540 LLKVVLGENLTSNCPEVIYEIKEETPVFYKLVPHPM---KNIYIYLTAGKEVRRIPVANCSKRKS 601

  Fly   542 CSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLH 606
            ||.||.:.||.||||...:|||.:..|....|...||.:.||          |:|.|..:
Mouse   602 CSECLAAADPHCGWCLPLQRCTFQGDCTHAGSFENWLDISSG----------PKKCPKIQ----- 651

  Fly   607 LIIRTLPE--------PFNAKY-RCVFGNSTPIDAEILENG-------LGCATPPLDERPLIPTN 655
             |:|:|.|        ..:|:: .||..|:.  ..::|..|       ..|..|   .||
Mouse   652 -ILRSLRERTTVTIVGSISARHSECVVKNAD--TGKLLCQGRSQLNWTCACNIP---SRP----- 705

  Fly   656 TDHILVPLSVRSSETNKDF------VSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSL 714
            :.::||        .|..|      :|..|.|.:|:....|..|::|  ||.||..|.||:|...
Mouse   706 SYNVLV--------VNATFSFPSWNLSERFNFTNCASLKECPACIRS--GCAWCKRDKKCIHPFT 760

  Fly   715 QCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLL 779
            .|.
Mouse   761 PCE-------------------------------------------------------------- 763

  Fly   780 PAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLC 844
            |:..|.|:.:                                                   |.:.
Mouse   764 PSDYERNQEL---------------------------------------------------CQVA 777

  Fly   845 VTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIE 909
            |.:.||                       .||                         ||.:
Mouse   778 VEKSPK-----------------------DSG-------------------------GGRV---- 790

  Fly   910 GSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQ-FH 973
                   :|..|.:                                          |:.:|| |:
Mouse   791 -------KESKRNR------------------------------------------TDGAVQVFY 806

  Fly   974 FKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQ 1038
            .|         .|.|:    ::|.:|| .|:..|...|          ||||:..:....:...:
Mouse   807 IK---------AIEPQ----KISTLGK-SNVIVTGANF----------TQASNITMILRGTSTCE 847

  Fly  1039 PEPIRSLHLVIDGANRTLECQISTPS---------ITNTNPTRSNFGSYQLRSLPRQPCSIFNYT 1094
            .:.||..|::.|     ...:.|.||         |.....|.|:.|:....:||.  ||:
Mouse   848 RDVIRVSHVLND-----THMKFSLPSSRKEMKDVCIQFDGGTCSSAGALSYIALPH--CSL---- 901

  Fly  1095 QDPRIMQIKPLRSFKSGGRVLTVHG----IYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECP 1155
                   |.|..::.|||:.:|:.|    :..|.|...||:   .|..||      ||.::. |.
Mouse   902 -------IVPATTWISGGQNITIMGRNFDVIDNLIISHELK---GNANVN------INVSEY-CA 949

  Fly  1156 SPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYF 1220
            :     .|..|...|        |::|..:|....|
Mouse   950 A-----TFCRFLAPN--------LKSSKVRTNVAVK----------------------------- 972

  Fly  1221 VNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDG---- 1281
                      ::|.:|.|:.                       .|:.||.||::..:..:.
Mouse   973 ----------LRVQDTYLDC-----------------------GTLQYLEDPRFTGYRVESEIDT 1004

  Fly  1282 ---VKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQ---CNITSLALNQ----LLCIPPEQQPLP 1336
               ||:.|      |.:..|::.|:.|:.:..|.::   |:..::..||    :||      .:.
Mouse  1005 ELEVKIQK------ENDNFNISKDDIDITLFHGENKQFNCSFENITRNQDLTTILC------KIK 1057

  Fly  1337 TDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYD-LNKPYVFSHALLVGILTVALLVVVFVIVLII 1400
            :.:|....::....|.||:| ||..   |::.: :...:.|..||.:      ||.:|.|:.:::
Mouse  1058 SIKNANTIASSSKKVRVKLG-NLEL---YVEQESVPSTWYFLIALPI------LLAIVIVVAVVV 1112

  Fly  1401 FRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTG-IPTLDHVNYIMK 1464
            .|.||.:..|:..:   |:..|||.:|.|.:..|||||.|..|:   ::|.| :|.||:.::.::
Mouse  1113 TRYKSKELSRKQSQ---QLELLESELRKEIRDGFAELQMDKLDV---VDSFGTVPFLDYKHFALR 1171

  Fly  1465 VFFP--GVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRV 1527
            .|||  |...|........|:.:.:   :.::...:.||.||.||:..|.|||.|: :||::||.
Mouse  1172 TFFPESGGFTHIFTEDMHNRDANDK---NESLTALDALICNKSFLVTVIHTLEKQK-NFSVKDRC 1232

  Fly  1528 NVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYL 1592
            ..||.:.:.|..|:.|.|.||: :|.|.:.:..::..|:||||||||||||:|||::::|:..:|
Mouse  1233 LFASFLTIALQTKLVYLTSILE-VLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFL 1296

  Fly  1593 KEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQ- 1656
            :|..|...:||...:..:|.||.||.||..|.|:|:|:.||.:....:.|.|:::.:.:.|...
Mouse  1297 RETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNVVFEKIPENESA 1361

  Fly  1657 --CR-----VNDWDTISQVKLKILDA-IFKN-TPFSMRPSVNEVDLEWRHGRGGHLTLQDE--DL 1710
              ||     |.|.|||.|.|.|:..| :.|| :|:.::  :||:.||.:.|     |.|.|  |:
Mouse  1362 DVCRNISVNVLDCDTIGQAKEKVFQAFLSKNGSPYGLQ--LNEIGLELQVG-----TRQKELLDI 1419

  Fly  1711 TTKTV---NGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHII 1772
            .:.:|   :|..:|||:.||.:...:.:.:                       |..|.|..|.:.
Mouse  1420 DSSSVILEDGITKLNTIGHYEISNGSTIKV-----------------------FKKIANFTSDVE 1461

  Fly  1773 INNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNK--TIPEVYLT 1835
            .::|         ..||:.|:                |.|||  ||.....|...  .:.|:|||
Mouse  1462 YSDD---------HCHLILPD----------------SEAFQ--VVQGKRHRGKHKFKVKEMYLT 1499

  Fly  1836 RLLATKGTIQKFVDDFFSIILTV-NEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLR 1899
            :||:||..|...::..|..|.:: |...|.|:|:.||.||..|....|.|.|:||.||:|.||||
Mouse  1500 KLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLR 1564

  Fly  1900 FWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMV 1964
            ||||.:|||.|:||:.||..:|||||||||.||||.|.:|.:|||::|:||||:|||||.|:..|
Mouse  1565 FWVNILKNPQFVFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEV 1629

  Fly  1965 KEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQ 2016
            |.:|:.:..||.:|..||...:.|.|.:...||:...||.|:|.||.||.|:
Mouse  1630 KSYYKAIRDLPPLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDE 1681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	84/446 (19%)
		PSI	535..586	CDD:396154	21/50 (42%)
		TIG_plexin	594..682	CDD:465588	23/109 (21%)
		PSI	683..730	CDD:214655	13/46 (28%)
		TIG_2	738..827	CDD:465619	3/88 (3%)
		PSI	836..877	CDD:214655	5/40 (13%)
		IPT_plexin_repeat1	888..976	CDD:238585	8/88 (9%)
		IPT_plexin_repeat2	977..1095	CDD:238584	27/126 (21%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	24/117 (21%)
		TIG	1277..>1334	CDD:460355	13/70 (19%)
		Plexin_cytopl	1452..2012	CDD:462434	209/580 (36%)
Plxnc1	XP_030101040.1	Sema_plexin_C1	185..594	CDD:200507	84/446 (19%)
		PSI	595..648	CDD:396154	23/62 (37%)
		PSI	731..774	CDD:396154	16/157 (10%)
		TIG	807..893	CDD:460355	24/114 (21%)
		TIG	897..987	CDD:460355	31/187 (17%)
		Plexin_cytopl	1159..1677	CDD:462434	208/579 (36%)