DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and PLXNB3

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001156729.1 Gene:PLXNB3 / 5365 HGNCID:9105 Length:1932 Species:Homo sapiens


Alignment Length:2136 Identity:659/2136 - (30%)
Similarity:1030/2136 - (48%) Gaps:360/2136 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQ 82
            ||::::|                 |||          |.:|:..               :.|.|.
Human    50 LCLLLLL-----------------LSP----------PPLPLTG---------------AHRFSA 72

  Fly    83 SKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC----HAGGCPEDIETS 143
            ......|::.......|:.||.|::.:|:..|::.|.|||||:.|||.|    ....||   :..
Human    73 PNTTLNHLALAPGRGTLYVGAVNRLFQLSPELQLEAVAVTGPVIDSPDCVPFRDPAECP---QAQ 134

  Fly   144 LVNNFNKILVVSYAHDGILIACGSIRQGACEIYSL---------PRFPATPQFFAVPLAANDENA 199
            |.:|.|::|:|| :....|:|||.:|||.||...|         ...|...||    :|||....
Human   135 LTDNANQLLLVS-SRAQELVACGQVRQGVCETRRLGDVAEVLYQAEDPGDGQF----VAANTPGV 194

  Fly   200 STYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL-DDLNYAEFSIQQSIINIDVKY 263
            :|...|.|.    ...|:|.|....  .|.....||.::.|:| ....::...:.:.::.....|
Human   195 ATVGLVVPL----PGRDLLLVARGL--AGKLSAGVPPLAIRQLAGSQPFSSEGLGRLVVGDFSDY 253

  Fly   264 RDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENN 328
            .:    .|:..|..:..|||:..::.:..  :|.|.:.:||:|:.|.|..||.|:.:.|..    
Human   254 NN----SYVGAFADARSAYFVFRRRGARA--QAEYRSYVARVCLGDTNLYSYVEVPLACQG---- 308

  Fly   329 VDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIEDMFIE 393
              ..:::.|.:.|.:               |:.||:     :....:::|:|.:.:.::.....:
Human   309 --QGLIQAAFLAPGT---------------LLGVFA-----AGPRGTQAALCAFPMVELGASMEQ 351

  Fly   394 NIHLCFNGTTKDRNLGYISGTINDG---RCPIVGSLGNIYNF-CS---VGLKISGVSPITAHALF 451
            ...||:....:..: |....|:..|   || :...|.:..:: |.   ....|:|..|:....|.
Human   352 ARRLCYTAGGRGPS-GAEEATVEYGVTSRC-VTLPLDSPESYPCGDEHTPSPIAGRQPLEVQPLL 414

  Fly   452 HFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE--YEEIVVDAGNRILPNTMMS 514
            .... .|::|.|...  ..|.:||||...|.:.||.|.| |.|:  :.:.|...|:.|.|:.::.
Human   415 KLGQ-PVSAVAALQA--DGHMIAFLGDTQGQLYKVFLHG-SQGQVYHSQQVGPPGSAISPDLLLD 475

  Fly   515 PKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWL- 578
            .....||||:..::.::.:..|..:.:|::||:::||.||||.|:.|||.:..|.|....::|| 
Human   476 SSGSHLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLW 540

  Fly   579 SLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLP-----EPFNAKYRCVFGNSTPIDAEILENG 638
            |......|:..:|::|...|..|...:.|.:..||     |.|:    |.||:...: |.:....
Human   541 SYEEDSHCLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFH----CAFGDYDSL-AHVEGPH 600

  Fly   639 LGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCS------HHGNCQECLQSS 697
            :.|.|||.|:.||.|..|||:.|||::...:..  ..:.||:|:|||      ....|:.|:.|.
Human   601 VACVTPPQDQVPLNPPGTDHVTVPLALMFEDVT--VAATNFSFYDCSAVQALEAAAPCRACVGSI 663

  Fly   698 WGCNWCIFDNKCVHKS---------LQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEI 753
            |.|:||...:.||:..         ...:.::..|...|.||.::......|:||.....:.|.:
Human   664 WRCHWCPQSSHCVYGEHCPEGERTIYSAQEVDIQVRGPGACPQVEGLAGPHLVPVGWESHLALRV 728

  Fly   754 ENLPKPKSAHAGFLCTIHIEAAQMLLPAHVE----SNKIVVCEKTPYFYEINTHEYQAKVVVTWN 814
            .||...:...|.|.|.:.:......|||.:|    .:.::.|:...::..::..|....:.||..
Human   729 RNLQHFRGLPASFHCWLELPGELRGLPATLEETAGDSGLIHCQAHQFYPSMSQRELPVPIYVTQG 793

  Fly   815 FQHYVDTA---IVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSN---SCVYNETCIADKNSI 873
            ....:|..   .|.||.| .:|    |||||.|...:....|.||::   :|.|...|       
Human   794 EAQRLDNTHALYVILYDC-AMG----HPDCSHCQAANRSLGCLWCADGQPACRYGPLC------- 846

  Fly   874 SSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELEN--Y 936
               ...|:|..||.|.||.::||:||.|||..:||.|||||....||:..:.:.|.||..|.  |
Human   847 ---PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLY 908

  Fly   937 QISVKIECRTGASLYEMSAPIKVA---NDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLI 998
            :.|.:|.|.|..:....:.|::||   ...|.  ||..|.:::.:|..|.|..||::|||||::.
Human   909 RTSARIVCVTSPAPNGTTGPVRVAIKSQPPGI--SSQHFTYQDPVLLSLSPRWGPQAGGTQLTIR 971

  Fly   999 GKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDG-ANRTLECQIST 1062
            |:.|..|....||:....|.| :.......:.|.|  ..|..|..:..||:.| |.|||   :::
Human   972 GQHLQTGGNTSAFVGGQPCPI-LEPVCPEAIVCRT--RPQAAPGEAAVLVVFGHAQRTL---LAS 1030

  Fly  1063 PSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQK 1127
            |                           |.||.:|:::..:|..||:.|||::.|.|..|:.:|:
Human  1031 P---------------------------FRYTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQR 1068

  Fly  1128 PELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKN 1192
            |.|.|:                                       ::.:..:|.|..|.:     
Human  1069 PLLSVW---------------------------------------LEADAEVQASRAQPQ----- 1089

  Fly  1193 EYDRKKRR---ADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNL-------------Q 1241
              |.:.||   |...|........|..        :..:|...|:.:.|.|             :
Human  1090 --DPQPRRSCGAPAADPQACIQLGGGL--------LQCSTVCSVNSSSLLLCRSPAVPDRAHPQR 1144

  Fly  1242 LSFVMDNVQLVRNLNKYFHDIRST-----IVYLADPKYLPFPNDG----VKLYKGDSLVIEGELL 1297
            :.|.:||||:         |..|.     .:|..:|:..|...:|    .:|..|..|.:|||.|
Human  1145 VFFTLDNVQV---------DFASASGGQGFLYQPNPRLAPLSREGPARPYRLKPGHVLDVEGEGL 1200

  Fly  1298 NLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFV 1362
            ||...:.:|.|.||..:|.:.:|....|.|.||...|.|.:.:|      ||..||::| |::..
Human  1201 NLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAHAPQPANGSG------LPQFVVQMG-NVQLA 1258

  Fly  1363 IGYLKYDLNKPY-VFSHALLVGI-LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESN 1425
            :|.::|:...|. .|......|: :..|:|:...:::.:::|.||.||.|:|:::.:|:.:||:.
Human  1259 LGPVQYEAEPPLSAFPVEAQAGVGMGAAVLIAAVLLLTLMYRHKSKQALRDYQKVLVQLESLETG 1323

  Fly  1426 VRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNY 1490
            |..:|::.|.:|.|:||||::|||.:|||.||:..|..:.||||....|:...|   ||..:..:
Human  1324 VGDQCRKEFTDLMTEMTDLSSDLEGSGIPFLDYRTYAERAFFPGHGGCPLQPKP---EGPGEDGH 1385

  Fly  1491 DA----AMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSL 1551
            .|    .:.|...|:.:|.|||..|.|||.| .|||.|||.:||||:.:.|..|:||.|:|:::|
Human  1386 CATVRQGLTQLSNLLNSKLFLLTLIHTLEEQ-PSFSQRDRCHVASLLSLALHGKLEYLTDIMRTL 1449

  Fly  1552 LLRLIDKSLAS----KHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIE 1612
            |     ..||:    ::|:|||||||::|||:|||:|:||:|.:|:|.||..|::||:||::|::
Human  1450 L-----GDLAAHYVHRNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVD 1509

  Fly  1613 KGLVDAITNDARYSLSEERLLHEQVTHSVVILHIL----------QDDLDEKVQCRVNDWDTISQ 1667
            ||.|||:|..|:.:|::.|||.|.|....:.|.:|          ..:: ::|..||.|.|||:|
Human  1510 KGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLMVLVGPGAGGAAGSSEM-QRVPARVLDTDTITQ 1573

  Fly  1668 VKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKES 1732
            ||.|:||.::|.||||.||||:.:|||||.|..|||||.|||||:.|.|.|||||||.||.|.:.
Human  1574 VKEKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG 1638

  Fly  1733 AVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDH 1797
            |.:.|:.:.:....|..|..|......|...:.:.:         |.|:   .::||||......
Human  1639 ATVGLVPQLHRGSTISQSLAQRCPLGENIPTLEDGE---------EGGV---CLWHLVKATEEPE 1691

  Fly  1798 YMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEEL 1862
            ...::.|.|....||..            |.|||:||||||:.|||:||||||.|..||:||..:
Human  1692 GAKVRCSSLREREPARA------------KAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPI 1744

  Fly  1863 PPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVI 1927
            |.|||:|||||||.|.:|.|.|...:|.||:|.|.||||||.:|||..||||..:.:||:.|:||
Human  1745 PIAVKYLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAILAVI 1809

  Fly  1928 AQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVR 1992
            ||||:|:|:||||::|:|||.||||:|::||.|:.||:.:|.|:.:....|.|||::|:.:||..
Human  1810 AQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSGN 1874

  Fly  1993 QNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGDCT 2048
            .......:.||:|||.:|.:|.|||:.:||.|...:|:.|:.:|..|||.::...|
Human  1875 YTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAALVENKVT 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 112/470 (24%)
PSI 535..586 CDD:279745 19/51 (37%)
PSI 683..730 CDD:214655 14/61 (23%)
PSI 836..877 CDD:214655 12/43 (28%)
IPT_plexin_repeat1 888..976 CDD:238585 35/92 (38%)
IPT_plexin_repeat2 977..1095 CDD:238584 31/118 (26%)
IPT_plexin_repeat3 1097..1211 CDD:238586 22/116 (19%)
Plexin_cytopl 1452..2017 CDD:285529 258/582 (44%)
PLXNB3NP_001156729.1 Sema_plexin_B3 70..495 CDD:200538 113/476 (24%)
PSI 497..548 CDD:279745 19/50 (38%)
IPT_plexin_repeat1 858..949 CDD:238585 35/92 (38%)
IPT_plexin_repeat2 950..1035 CDD:238584 30/117 (26%)
IPT 1038..1169 CDD:301692 35/193 (18%)
TIG <1199..1265 CDD:280079 23/72 (32%)
Plexin_cytopl 1350..1899 CDD:285529 258/582 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10786
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.820

Return to query results.
Submit another query.